| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5607 |
Name | MAP2K5 |
Synonym | HsT17454|MAPKK5|MEK5|PRKMK5;mitogen-activated protein kinase kinase 5;MAP2K5;mitogen-activated protein kinase kinase 5 |
Definition | MAP kinase kinase 5|MAP kinase kinase MEK5b|MAPK/ERK kinase 5|MAPKK 5|MEK 5|dual specificity mitogen-activated protein kinase kinase 5 |
Position | 15q23 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | mapkinase signaling pathway;PID BioCarta;100113 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | Trk receptor signaling mediated by the MAPK pathway;PID Curated;200182 |
Pathway | role of erk5 in neuronal survival pathway;PID BioCarta;100171 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Signalling to ERK5;PID Reactome;500644 |
Disease | Restless legs syndrome;NHGRI |
Disease | restless legs syndrome;GAD |
Disease | NEUROLOGICAL;GAD |
Disease | Body mass index;NHGRI |
External Links | |
Links to Entrez Gene | 5607 |
Links to all GeneRIF Items | 5607 |
Links to iHOP | 5607 |
Sequence Information | |
Nucleotide Sequence | >5607 : length: 2486 CTTTTCCAACATGGCGCCGCGGGAGGCGGGTCCCGCTCGTCGGCTCCCGGGGTTCCGGCG CCGCGCGTTTTGGTTCCGGAGTAACAGTGTCGCCGCCGCCTTCCTCCTCCTCCTCTCGCC GCTACCGCCGTCGCCGCCGCCGCAGCCGCCGCCAGTCCGCGCGGCCTCGGGTGGCCGGAG CTCAGCCTGCGCGCGCCGCGCCCTGTGTCTCCGGGTGGGGCAGAAGACTCGCCCCTTGAA CCTCCCGCGGGGACTCTCCGTGGTGTGGCGGCCCTGGGGCTCTTTCTTAATAGCCCCGGA CTGAGTCCCCTCCAGTCGAGGACCCTCTCCTAGTCCACTGACGAGCGGTGGACACCTGCC GCTGTATCTCCCCCAAACCGAGTCCTTGCCCTGCTGCCTCCTCATACCCACACGGCGGCA GAGACCTTCACCATAGCGTTCGCTCAACTCCAGAACCTTCCGACCTCCGCTAGTTCCTGC GGGCCTTTGCCCGCTTCCCGGTGCACCCTCCCCGGGAGACACCTCAGACCCCCGACAGCC TGGGCAGGCTCGGTGCCTGCGGGTGCGTTCCTGATCACCCCTCCCCTCTTCCCTCCCCCT CATCCTCCATTCCCTTGTTTTCACCCTCTGTCCTCTGCCCGTCACTCCCCTTGTCACCTC TTGGAGCCCCCTCCTAACCAGCGGCCAGTGGGTTTCCCATACCCCAGGATGTGAGCCTCT TTAACCTGTAATGCTGTGGCTAGCCCTTGGCCCCTTTCCTGCCATGGAGAACCAGGTGCT GGTAATTCGCATCAAGATCCCAAATAGTGGCGCGGTGGACTGGACAGTGCACTCCGGGCC GCAGTTACTCTTCAGGGATGTGCTGGATGTGATAGGCCAGGTTCTGCCTGAAGCAACAAC TACAGCATTTGAATATGAAGATGAAGATGGTGATCGAATTACAGTGAGAAGTGATGAGGA AATGAAGGCAATGCTGTCATATTATTATTCCACAGTAATGGAACAGCAAGTAAATGGACA GTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACAT ACATGGCCTGAAGGTGAATACTCGGGCCGGACCCTCTCAACACAGCAGCCCAGCAGTCTC AGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTTCTGCTGAACTGAAAAAAATACTAGC CAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAACGG AGGCACAGTCTACAAAGCATATCATGTCCCGAGTGGGAAAATATTAGCTGTAAAGGTCAT ACTACTAGATATTACACTGGAACTTCAGAAGCAAATTATGTCTGAATTGGAAATTCTTTA TAAGTGCGATTCATCATATATCATTGGATTTTATGGAGCATTTTTTGTAGAAAACAGGAT TTCAATATGTACAGAATTCATGGATGGGGGATCTTTGGATGTATATAGGAAAATGCCAGA ACATGTCCTTGGAAGAATTGCAGTAGCAGTTGTTAAAGGCCTTACTTATTTGTGGAGTTT AAAGATTTTACATAGAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGT TAAGCTGTGTGATTTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCCAAGACGTATGT TGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGAATTCATTC TGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCC TCAGATTCAGAAAAACCAGGGATCTTTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTGA TGAGAGAAAAGTGTACTGTCAAGTCCTGCAGTGCAGAGAACACTCTCAGGATTCGCCCGT CCTTCCAGTTGGAGAGTTCTCGGAGCCATTTGTACATTTCATCACTCAGTGTATGCGAAA ACAGCCAAAAGAAAGGCCAGCACCTGAAGAATTGATGGGCCACCCGTTCATCGTGCAGTT CAATGATGGAAATGCCGCCGTGGTGTCCATGTGGGTGTGCCGGGCGCTGGAGGAGAGGCG GAGCCAGCAGGGGCCCCCGTGAGGCTGCCGCAGGGCACTGAAAGCCCAGGACCAGTAACC AAGGAGAACAACCCACCCGTCGCCCTTCTCCGTATGCTGCCTGCGCCAGAAGAGCTTTGC TGGGCCCTGGCTTCCCTGCCCTCGCCTTCACCTCTGTCAGCAGGTGGCCTTGCCTGGGGA GCCCCATGTGTGGCCCACCCCACCAGGCCATCCCCATACCTTCTGGTTTGAAGGCGCTGA CACTGGCAGAGAGGTAAAGGGTGGGGCATTGAGAATGGAGGCTCCCAGGGTCCCTGCCCA CTTCTGTTTTCCTAATGTTTTTCTCTATAAAGGGTCAGGCCCGTCAGCATCACTGATGGG AATAAAAGTATTAATGCTTTGTGACA |
Protein Sequence | >5607 : length: 463 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ KNQGSLMPLQLLQCIVDERKVYCQVLQCREHSQDSPVLPVGEFSEPFVHFITQCMRKQPK ERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQQGPP |