Entrez Gene

Cancer metastasis gene database Home

General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information
Gene ID	5328
Name	PLAU
Synonymous	plasminogen activator, urokinase;PLAU;plasminogen activator, urokinase
Definition	U-plasminogen activator\|plasminogen activator, urinary\|urokinase-type plasminogen activator
Position	10q22.2
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
uPA(h) --> uPA(h) (expression).
uPA(h) --> uPA(h) (expression).
Lck(m.s.) --> uPA(h) (increase of abundance)
Sos1(m.s.) --> uPA(h) (increase of promoter activity)
uPA(h) --> urokinase-type plasminogen activator isoform 2(h) (expression).
hsa-miR-193b --/ urokinase-type plasminogen activator isoform 2(h) (increase of mRNA decay).
uPA(h) --> urokinase-type plasminogen activator isoform 1 preproprotein(h) (expression).
hsa-miR-193b --/ urokinase-type plasminogen activator isoform 1 preproprotein(h) (increase of mRNA decay).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
38	O-linked (Fuc).		Swiss-Prot 53.0
158	Phosphoserine.		Swiss-Prot 53.0
323	Phosphoserine.		Swiss-Prot 53.0
158	Phosphoserine (PKC alpha)	9765311	Phospho.ELM 6.0
323	Phosphoserine (PKC alpha)	9765311	Phospho.ELM 6.0
38	O-linked	Buko AM., Kentzer EJ., Petros A., Menon G., Zuiderweg ER. andSarin VK. (1991)Proc. Natl. Acad. Sci., 88, 3992-3996. Medline: 91219498;	OGlycBase6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr10	Promoter: 75339396 - 75341396	Agilent_014791
chr10	Promoter: 75339396 - 75341396	GoldenGate_Methylation_Cancer_Panel_I
chr10	Promoter: 75339396 - 75341396	GSE27584
chr10	Promoter: 75339396 - 75341396	Agilent_014791_44K
chr10	Promoter: 75339396 - 75341396	PMID:12198113
chr10	Promoter: 75339396 - 75341396	PMID:10209960