| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4803 |
Name | NGF |
Synonymous | nerve growth factor (beta polypeptide);NGF;nerve growth factor (beta polypeptide) |
Definition | beta-nerve growth factor|nerve growth factor, beta subunit |
Position | 1p13.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | NGF(h) --> FRS2(h){pY} (increase of phosphorylation) | NGF(h) --> ERK1(h){p} (increase of phosphorylation) | NGF(h) --> ERK2(h){p} (increase of phosphorylation) | NGFB(h) --> NGF(h) (expression). | NGF(h) --> FOXO3a(r){pT32}{pS253} (increase of phosphorylation) | trkA(h) + NGF(h) <==> trkA(h):NGF(h) (binding) | NGF(h) --> AKT(r){p} (increase of phosphorylation) | NGF(h) --> FOXO3a(m){pT32}{pS252} (increase of phosphorylation) | NGF(h) --> p85(r){pY} (increase of phosphorylation) | NGF(h) --> ERK1(r){p} (increase of phosphorylation) | NGF(h) --> ERK2(r){p} (increase of phosphorylation) | NGF(h) --> FOXO1A(r){p} (increase of phosphorylation) | NGF(h) --> foxo4(r){p} (increase of phosphorylation) | 2 NGF(h) + p75NTR(r) <==> (NGF(h))2:p75NTR(r) (binding) | p75NTR(r) + NGF(h) <==> p75NTR(r):NGF(h) (binding) | NGF(h) --> PARP-p85(h) (decrease of cleavage) | NGF(h) --> ERK2(h){pY} (increase of phosphorylation) | NGF(h) --> BEX1(r) (increase of abundance) | NGF(h) --> ERK(r){p} (increase of phosphorylation) | NGF(h) --> SHP-2(r):p85(r) (increase of binding) | NGF(h) --> SHP-2(r):Shc(r) (increase of binding) | NGF(h) + carboxypeptidase E(m) <==> NGF(h):carboxypeptidase E(m) (binding) | carboxypeptidase E(b) + NGF(h) <==> carboxypeptidase E(b):NGF(h) (binding) | NGF(h) --> PLCgamma1(h){pY} (increase of phosphorylation) | 2 p75NTR-ECD(h) + 2 NGF(h) <==> (p75NTR-ECD(h))2:(NGF(h))2 (binding) | NGFB(h) --> NGF(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 69 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 84 | Phosphoserine. | Swiss-Prot 53.0 | 114 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr1 |
Promoter: 115681880 - 115683880 | GoldenGate_Methylation_Cancer_Panel_I |
chr1 |
Promoter: 115681880 - 115683880 | GSE27584 |
chr1 |
Promoter: 115681880 - 115683880 | Agilent_014791_44K |