Entrez Gene

Basic Information
Gene ID	4157
Name	MC1R
Synonymous	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor);MC1R;melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Definition	MC1-R\|melanocyte-stimulating hormone receptor\|melanotropin receptor
Position	16q24.3
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
mc1r(h) + alpha-MSH(m.s.) <==> mc1r(h):alpha-MSH(m.s.) (binding)
MC1R(h) --> mc1r(h) (expression).
UV --> mc1r(h) (increase of abundance)
2 mc1r(h) <==> (mc1r(h))2 (binding; oligomerization)
mc1r(h) + NDP-Gly --> mc1r(h){glyN155} + NMP (glycosylation)
mc1r(h) --> MITF(h) (transactivation)
mc1r(h) --> TYR(h) (transactivation)
beta-MSH(m.s.) + mc1r(h) <==> mc1r(h):beta-MSH(m.s.) (binding)
gamma-MSH(m.s.) + mc1r(h) <==> mc1r(h):gamma-MSH(m.s.) (binding)
ACTH(m.s.) + mc1r(h) <==> mc1r(h):ACTH(m.s.) (binding)
opiomelanocortin(m.s.) + mc1r(h) <==> opiomelanocortin(m.s.):mc1r(h) (binding)
mc1r(h) --> mc1r(h) (expression).
mc1r-xbb1(h) --/ MITF(h) (transrepression)
mc1r-xbb1(h) --/ TYR(h) (transrepression)
MC1R(h) --> mc1r-xbb1(h) (expression).

Location (AA)	PTM type	Database
Post Translational Modification [Top]
29	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
315	S-palmitoyl cysteine (Potential).	Swiss-Prot 53.0

Transcription Factors [Top]