| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4157 |
Name | MC1R |
Synonym | CMM5|MSH-R|SHEP2;melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor);MC1R;melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
Definition | MC1-R|melanocyte-stimulating hormone receptor|melanotropin receptor |
Position | 16q24.3 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Neuroactive ligand-receptor interaction;KEGG PATHWAY;hsa04080 |
Pathway | Melanogenesis;KEGG PATHWAY;hsa04916 |
Disease | Skin/hair/eye pigmentation 2, red hair/fair skin;OMIM |
Disease | Tanning;NHGRI |
Disease | Analgesia from kappa-opioid receptor agonist, female-specific;OMIM |
Disease | Skin tumor;FunDO |
Disease | Carcinoma, Basal Cell;GAD |
Disease | squamous cell carcinoma;GAD |
Disease | skin cancer, nonmelanoma;GAD |
Disease | skin cancer;GAD |
Disease | DEVELOPMENTAL;GAD |
Disease | Black vs red hair color;GAD |
Disease | Blond vs. brown hair color;NHGRI |
Disease | solar lentigines;GAD |
Disease | tanning;GAD |
Disease | Freckling;NHGRI |
Disease | melanoma, cutaneous;GAD |
Disease | red vs non-red hair color;GAD |
Disease | Blond vs brown hair color;GAD |
Disease | prostate cancer;GAD |
Disease | Melanoma;NHGRI |
Disease | Black vs. red hair color;NHGRI |
Disease | Freckles;NHGRI |
Disease | skin sensitivity to sun;GAD |
Disease | Skin Neoplasms;GAD |
Disease | Red vs non-red hair color;NHGRI |
Disease | freckles;GAD |
Disease | Sarcoma;FunDO |
Disease | vulvar vestibulitis syndrome;GAD |
Disease | CANCER;GAD |
Disease | melanoma;GAD |
Disease | Skin/hair/eye pigmentation 2, blond hair/fair skin;OMIM |
Disease | Melanoma susceptibility 5;OMIM |
Disease | breast cancer melanoma;GAD |
Disease | Skin sensitivity to sun;NHGRI |
Disease | ephelides;GAD |
Disease | UV-induced skin damage;OMIM |
Disease | cutaneous melanoma which is largely independent of skin type and hair color;GAD |
Disease | Skin disease;FunDO |
Disease | Hair color;NHGRI |
Disease | Skin cancer;FunDO |
Disease | Oculocutaneous albinism, type II, modifier of;OMIM |
Disease | oculocutaneous albinism type 2;GAD |
External Links | |
Links to Entrez Gene | 4157 |
Links to all GeneRIF Items | 4157 |
Links to iHOP | 4157 |
Sequence Information | |
Nucleotide Sequence | >4157 : length: 3115 AGACGCAGTCTTCAGCAAGGAAGTGCTGGGAACGCCCTGGAGTGAACCCAGGAAGATGCC TGCAGTGGGTGCCAGGGCCCCTCTCCACCGTCCCTGCTGGGCTTCGGGGCCACGCCCGAC TGCTGTGAACGGCCTGCGGAGCACCACGTGCGACGGCTGGAGGCGAGAGGTCTGCCTTTG ATGTGGCTGTTGGTGCAGGGCCTGTGGTGCCTTCCGCAGCGGAAATGGCGCGCCGCCCGG GGAGGGCGGGAGCAGCGTCCCGGGTGCCCCTGTGAGGATGAGCGACGAGATGACTGGAGG GTCCCTGAAGACCTCACTAGGGTGCCCCCAGCCGGTCCGCTCCCAGGAAGCGACACCCCC ACAGCCCCAGGGCTGCAGCTGAGGGGGTCGCCACTCTGGCTGGGCGAGGCTGGGCCCTTG GGGGCAGGCGCCAGAGTGGCCTCAGGCTCTACAAGATGCCTGAAAACACCAACCTCTCCA GGGCTCACTAGCATTGGACGCTTTCACGCTCTGCCCTGGCCGGAAGCCCCCTCACCCCGC GCGATGTGCAAACTCCTGCAGGGCTCACTCAGTTTCCAGAACTTTAATTATTGGAAAGTT CTCCCTGGTCCAGCCCCCAAATCTGCCGTGAACGTTGACAGCTGAGTTGCTGCTCCATGC GTGCTTTGGCTGAGAGCAGAGGGGACCCCTGTCCTCCCTGAGCTGCTGACGAGGGGAGGG GTGAAGGGTGGGGCCTCTGGAGAGGGCAGGTCCCGGGGAAGCTCCGGACTCCTAGAGGGG CGGCCAGGTGGGGGCCCTGGTGACCAGGACAGACTGTGGTGTTTTTTAACGTAAAGGAGA TCCGCGGTGTGAGGGACCCCCTGGGTCCTGCACGCCGCCTGGTGGCAGGCCGGGCCATGG TGGGTGCTCACGCCCCCGGCATGTGGCCGCCCTCAGTGGGAGGGGCTCTGAGAACGACTT TTTAAAACGCAGAGAAAAGCTCCATTCTTCCCAGGACCTCAGCGCAGCCCTGGCCCAGGA AGGCAGGAGACAGAGGCCAGGACGGTCCAGAGGTGTCGAAATGTCCTGGGGACCTGAGCA GCAGCCACCAGGGAAGAGGCAGGGAGGGAGCTGAGGACCAGGCTTGGTTGTGAGAATCCC TGAGCCCAGGCGGTAGATGCCAGGAGGTGTCTGGACTGGCTGGGCCATGCCTGGGCTGAC CTGTCCAGCCAGGGAGAGGGTGTGAGGGCAGATCTGGGGGTGCCCAGATGGAAGGAGGCA GGCATGGGGGACACCCAAGGCCCCCTGGCAGCACCATGAACTAAGCAGGACACCTGGAGG GGAAGAACTGTGGGGACCTGGAGGCCTCCAACGACTCCTTCCTGCTTCCTGGACAGGACT ATGGCTGTGCAGGGATCCCAGAGAAGACTTCTGGGCTCCCTCAACTCCACCCCCACAGCC ATCCCCCAGCTGGGGCTGGCTGCCAACCAGACAGGAGCCCGGTGCCTGGAGGTGTCCATC TCTGACGGGCTCTTCCTCAGCCTGGGGCTGGTGAGCTTGGTGGAGAACGCGCTGGTGGTG GCCACCATCGCCAAGAACCGGAACCTGCACTCACCCATGTACTGCTTCATCTGCTGCCTG GCCTTGTCGGACCTGCTGGTGAGCGGGAGCAACGTGCTGGAGACGGCCGTCATCCTCCTG CTGGAGGCCGGTGCACTGGTGGCCCGGGCTGCGGTGCTGCAGCAGCTGGACAATGTCATT GACGTGATCACCTGCAGCTCCATGCTGTCCAGCCTCTGCTTCCTGGGCGCCATCGCCGTG GACCGCTACATCTCCATCTTCTACGCACTGCGCTACCACAGCATCGTGACCCTGCCGCGG GCGCGGCGAGCCGTTGCGGCCATCTGGGTGGCCAGTGTCGTCTTCAGCACGCTCTTCATC GCCTACTACGACCACGTGGCCGTCCTGCTGTGCCTCGTGGTCTTCTTCCTGGCTATGCTG GTGCTCATGGCCGTGCTGTACGTCCACATGCTGGCCCGGGCCTGCCAGCACGCCCAGGGC ATCGCCCGGCTCCACAAGAGGCAGCGCCCGGTCCACCAGGGCTTTGGCCTTAAAGGCGCT GTCACCCTCACCATCCTGCTGGGCATTTTCTTCCTCTGCTGGGGCCCCTTCTTCCTGCAT CTCACACTCATCGTCCTCTGCCCCGAGCACCCCACGTGCGGCTGCATCTTCAAGAACTTC AACCTCTTTCTCGCCCTCATCATCTGCAATGCCATCATCGACCCCCTCATCTACGCCTTC CACAGCCAGGAGCTCCGCAGGACGCTCAAGGAGGTGCTGACATGCTCCTGGTGAGCGCGG TGCACGCGGCTTTAAGTGTGCTGGGCAGAGGGAGGTGGTGATATTGTGTGGTCTGGTTCC TGTGTGACCCTGGGCAGTTCCTTACCTCCCTGGTCCCCGTTTGTCAAAGAGGATGGACTA AATGATCTCTGAAAGTGTTGAAGCGCGGACCCTTCTGGGTCCAGGGAGGGGTCCCTGCAA AACTCCAGGCAGGACTTCTCACCAGCAGTCGTGGGGAACGGAGGAGGACATGGGGAGGTT GTGGGGCCTCAGGCTCCGGGCACCAGGGGCCAACCTCAGGCTCCTAAAGAGACATTTTCC GCCCACTCCTGGGACACTCCGTCTGCTCCAATGACTGAGCAGCATCCACCCCACCCCATC TTTGCTGCCAGCTCTCAGGACCGTGCCCTCGTCAGCTGGGATGTGAAGTCTCTGGGTGGA AGTGTGTGCCAAGAGCTACTCCCACAGCAGCCCCAGGAGAAGGGGCTTTGTGACCAGAAA GCTTCATCCACAGCCTTGCAGCGGCTCCTGCAAAAGGAGGTGAAATCCCTGCCTCAGGCC AAGGGACCAGGTTTGCAGGAGCCCCCCTAGTGGTATGGGGCTGAGCCCTCCTGAGGGCCG GTTCTAAGGCTCAGACTGGGCACTGGGGCCTCAGCCTGCTTTCCTGCAGCAGTCGCCCAA GCAGACAGCCCTGGCAAATGCCTGACTCAGTGACCAGTGCCTGTGAGCATGGGGCCAGGA AAGTCTGGTAATAAATGTGACTCAGCATCACCCACCTTAAAAAAAAAAAAAAAAA |
Protein Sequence | >4157 : length: 317 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF HSQELRRTLKEVLTCSW |