| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3716 |
Name | JAK1 |
Synonymous | Janus kinase 1;JAK1;Janus kinase 1 |
Definition | tyrosine-protein kinase JAK1 |
Position | 1p32.3-p31.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Jak1(h) + ATP --> Jak1(h){pY} + ADP (phosphorylation) | IL-4Ralpha(h) + Jak1(h) <==> IL-4Ralpha(h):Jak1(h) (binding) | IL-2Rbeta(h) + Jak1(h) <==> IL-2Rbeta(h):Jak1(h) (binding) | IL-10R1(h) + Jak1(h) <==> IL-10R1(h):Jak1(h) (binding) | IFNAR2(h) + Jak1(h) <==> IFNAR2(h):Jak1(h) (binding) | EpoR(h) + Jak1(h) <==> EpoR(h):Jak1(h) (binding) | IFNGR(h) + Jak1(h) <==> IFNGR(h):Jak1(h) (binding) | Tyk2(h) + Jak1(h) <==> Tyk2(h):Jak1(h) (binding) | Jak1(h) + uPAR(h) <==> Jak1(h):uPAR(h) (binding) | Jak1(h) + uPAR(h):scuPA(m.s.) <==> Jak1(h):uPAR(h):scuPA(m.s.) (binding) | Jak1(h) + IRS-2(h) <==> Jak1(h):IRS-2(h) (binding) | Jak1(h) + IRS-1(h) <==> Jak1(h):IRS-1(h) (binding) | Jak1(h) + IL-5Ralpha(h) <==> Jak1(h):IL-5Ralpha(h) (binding) | Jak1(h) + IL-5Rbeta(h) <==> Jak1(h):IL-5Rbeta(h) (binding) | Jak1(h) + cytosolic phospholipase A2(h){pY} <==> Jak1(h):cytosolic phospholipase A2(h){pY} (binding) | Jak1(h) + ATP --> Jak1(h){p} + ADP (phosphorylation) | Jak1(h) + ATP --> Jak1(h){p} + ADP (phosphorylation; automodification) | brca1(h) + Jak1(h) <==> brca1(h):Jak1(h) (binding) | Jak1(h) + STAT1(h) <==> Jak1(h):STAT1(h) (binding) | Jak1(h) + 2 ATP --> Jak1(h){pY1033}{pY1034} + 2 ADP (phosphorylation) | bifunctional purine biosynthesis protein PURH(h) + Jak1(h) <==> bifunctional purine biosynthesis protein PURH(h):Jak1(h) (binding) | beta-arrestin1(h) + Jak1(h) <==> beta-arrestin1(h):Jak1(h) (binding) | ESE-1(h) + Jak1(h) <==> ESE-1(h):Jak1(h) (binding) | Jak1(h) + TNFR1(h) <==> Jak1(h):TNFR1(h) (binding) | Jak1(h) + Hsp90(h) <==> Jak1(h):Hsp90(h) (binding) | Jak1(h) + PLCgamma(h) <==> Jak1(h):PLCgamma(h) (binding) | Jak1(h) + SHP-2(h) + PKCbeta(h) + RACK1(h) <==> RACK1(h):SHP-2(h):Jak1(h):PKCbeta(h) (binding) | IL-17A(h) --> Jak1(h) (activation; phosphorylation) | JAK1(h) --> Jak1(h) (expression). | Jak1(h){pY} --CD45(h)--> p + Jak1(h) (dephosphorylation) | IFNgamma(h) --> Jak1(h) (increase of abundance) | STAT6(h) + ATP --Jak1(h)--> STAT6(h){pY} + ADP (phosphorylation) | SHP-2(h) + ATP --Jak1(h)--> SHP-2(h){p} + ADP (phosphorylation) | ErbB1-p170(h){pY1016} + Jak1(h) <==> ErbB1-p170(h){pY1016}:Jak1(h) (binding) | ErbB2(h){pY1023}{pY1139} + Jak1(h) <==> ErbB2(h){pY1023}{pY1139}:Jak1(h) (binding) | ErbB3-isoform1(h) + Jak1(h) <==> ErbB3-isoform1(h):Jak1(h) (binding) | ErbB4(h) + Jak1(h) <==> ErbB4(h):Jak1(h) (binding) | IFNAR2(h) + Jak1(h) <==> IFNAR2(h):Jak1(h) (binding) | Jak1(h) + ATP --> Jak1(h){pY} + ADP (phosphorylation) | JAK1(h) --> Jak1(h) (expression). |
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Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 1022 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 1022 | Phosphotyrosine (JAK3) | 12559972;15659558;15659558 | Phospho.ELM 6.0 | 1023 | Phosphotyrosine (JAK3) | 12559972;15659558;15659558 | Phospho.ELM 6.0 | 208 | Phosphotyrosine | 15659558 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for JAK1 | ||