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Cancer metastasis database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

3716

Name

JAK1

Synonymous

Janus kinase 1;JAK1;Janus kinase 1

Definition

tyrosine-protein kinase JAK1

Position

1p32.3-p31.3

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 CISHNCI_NATURE;

in same component

 DOK2NCI_NATURE;

in same component

 EBI3NCI_NATURE;

in same component

 FESNCI_NATURE;

in same component

 FYNNCI_NATURE;

in same component

 GAB2NCI_NATURE;

in same component

 HCKNCI_NATURE;

in same component

 IFNAR1REACTOME;

in same component

 IFNGNCI_NATURE;

in same component

 IFNGREACTOME;

in same component

 IFNGR1NCI_NATURE;

in same component

 IFNGR1REACTOME;

in same component

 IFNGR2REACTOME;

in same component

 IL13RA1NCI_NATURE;

in same component

 IL27NCI_NATURE;

in same component

 IL27RANCI_NATURE;

in same component

 IL2NCI_NATURE;

in same component

 IL2REACTOME;

in same component

 IL2RANCI_NATURE;

in same component

 IL2RAREACTOME;

in same component

 IL2RBNCI_NATURE;

in same component

 IL2RBREACTOME;

in same component

 IL2RGNCI_NATURE;

in same component

 IL2RGREACTOME;

in same component

 IL4NCI_NATURE;

in same component

 IL4RNCI_NATURE;

in same component

 IL6NCI_NATURE;

in same component

 IL6RNCI_NATURE;

in same component

 IL6STNCI_NATURE;

in same component

 INPP5DNCI_NATURE;

in same component

 IRS1NCI_NATURE;

in same component

 IRS2NCI_NATURE;

in same component

 JAK2NCI_NATURE;

in same component

 JAK2REACTOME;

in same component

 JAK3NCI_NATURE;

in same component

 JAK3REACTOME;

in same component

 LCKNCI_NATURE;

in same component

 PIK3CANCI_NATURE;

in same component

 PIK3R1NCI_NATURE;

in same component

 PTK2BNCI_NATURE;

in same component

 PTPN11NCI_NATURE;

in same component

 PTPN6NCI_NATURE;

in same component

 SHC1NCI_NATURE;

in same component

 SHC1REACTOME;

in same component

 SOCS1NCI_NATURE;

in same component

 SOCS2NCI_NATURE;

in same component

 SOCS3NCI_NATURE;

in same component

 SOS1NCI_NATURE;

in same component

 STAT2REACTOME;

in same component

 SYKNCI_NATURE;

in same component

 SYKREACTOME;

in same component

 TYK2REACTOME;

interacts with

 ABL1BIOGRID;

interacts with

 ABL2BIOGRID;

interacts with

 ACACAINTACT;

interacts with

 ANKRD11INTACT;

interacts with

 APAF1INTACT;

interacts with

 ARMC1INTACT;

interacts with

 ARRB1BIOGRID;

interacts with

 ASXL1INTACT;

interacts with

 ATICBIOGRID;

interacts with

 BAG3INTACT;

interacts with

 BAZ1BINTACT;

interacts with

 BAZ2BINTACT;

interacts with

 BDP1INTACT;

interacts with

 BRCA1BIOGRID;

interacts with

 BRCA1MINT;

interacts with

 BTKBIOGRID;

interacts with

 BTKHPRD;

interacts with

 CCR1HPRD;

interacts with

 CCR5HPRD;

interacts with

 CSF2RBHPRD;

interacts with

 CSF3RBIOGRID;

interacts with

 CSF3RHPRD;

interacts with

 CXCR4HPRD;

interacts with

 DHX30INTACT;

interacts with

 Dlg4MINT;

interacts with

 DNMT1INTACT;

interacts with

 EIF2AK2HPRD;

interacts with

 ELF3BIOGRID;

interacts with

 ELP2BIOGRID;

interacts with

 ELP2HPRD;

interacts with

 ERBB2MINT;

interacts with

 ERBB4INTACT;

interacts with

 FANCCINTACT;

interacts with

 FERHPRD;

interacts with

 FESHPRD;

interacts with

 GHRBIOGRID;

interacts with

 GHRHPRD;

interacts with

 GRHL2INTACT;

interacts with

 IFNAR2BIOGRID;

interacts with

 IFNAR2MINT;

interacts with

 IFNGR1BIOGRID;

interacts with

 IFNGR1HPRD;

interacts with

 IGF1RBIOGRID;

interacts with

 IGF1RHPRD;

interacts with

 IL10RABIOGRID;

interacts with

 IL10RAHPRD;

interacts with

 IL21RBIOGRID;

interacts with

 IL21RHPRD;

interacts with

 IL27RABIOGRID;

interacts with

 IL2RBBIOGRID;

interacts with

 IL2RBHPRD;

interacts with

 IL2RGHPRD;

interacts with

 IL3RAHPRD;

interacts with

 IL4RBIOGRID;

interacts with

 IL4RHPRD;

interacts with

 IL5RABIOGRID;

interacts with

 IL6RMINT;

interacts with

 IL6STBIOGRID;

interacts with

 IL6STHPRD;

interacts with

 IL7RHPRD;

interacts with

 IL9RBIOGRID;

interacts with

 IL9RHPRD;

interacts with

 INPP5DHPRD;

interacts with

 INSRHPRD;

interacts with

 IRS1BIOGRID;

interacts with

 IRS1HPRD;

interacts with

 IRS2BIOGRID;

interacts with

 IRS2HPRD;

interacts with

 ITCHINTACT;

interacts with

 JAK2INTACT;

interacts with

 JAK3HPRD;

interacts with

 JAKMIP1HPRD;

interacts with

 KAT2AINTACT;

interacts with

 LATS2INTACT;

interacts with

 LMO7INTACT;

interacts with

 MAP3K1INTACT;

interacts with

 MDKHPRD;

interacts with

 MED1INTACT;

interacts with

 MLL5INTACT;

interacts with

 NCOR1INTACT;

interacts with

 NCOR2INTACT;

interacts with

 NSD1INTACT;

interacts with

 OSMRHPRD;

interacts with

 PARP1INTACT;

interacts with

 PDGFRAHPRD;

interacts with

 PDGFRBHPRD;

interacts with

 PHKA1INTACT;

interacts with

 PIK3CGINTACT;

interacts with

 PIK3R1HPRD;

interacts with

 PKD1L3INTACT;

interacts with

 PLA2G4AHPRD;

interacts with

 PLAURBIOGRID;

interacts with

 PLAURHPRD;

interacts with

 PLCG2HPRD;

interacts with

 PPEF2INTACT;

interacts with

 PRKCAMINT;

interacts with

 PRKCZHPRD;

interacts with

 PRMT5BIOGRID;

interacts with

 PRMT5HPRD;

interacts with

 PTK2BBIOGRID;

interacts with

 PTK2BHPRD;

interacts with

 PTPN11BIOGRID;

interacts with

 PTPN11HPRD;

interacts with

 PTPN6BIOGRID;

interacts with

 PTPN6HPRD;

interacts with

 PTPRCHPRD;

interacts with

 RAF1BIOGRID;

interacts with

 RAF1HPRD;

interacts with

 RARAINTACT;

interacts with

 RSF1INTACT;

interacts with

 SETD2INTACT;

interacts with

 SH2B2HPRD;

interacts with

 SHBBIOGRID;

interacts with

 SHBHPRD;

interacts with

 SOCS1HPRD;

interacts with

 SOCS3HPRD;

interacts with

 STAM2BIOGRID;

interacts with

 STAM2HPRD;

interacts with

 STAM2MINT;

interacts with

 STAMHPRD;

interacts with

 STAT1CELL_MAP;

interacts with

 STAT1HPRD;

interacts with

 STAT2HPRD;

interacts with

 STAT3BIOGRID;

interacts with

 STAT3CELL_MAP;

interacts with

 STAT3HPRD;

interacts with

 STAT5ABIOGRID;

interacts with

 STAT5AHPRD;

interacts with

 STAT5BBIOGRID;

interacts with

 STAT6HPRD;

interacts with

 SYKHPRD;

interacts with

 TAF5LINTACT;

interacts with

 TECBIOGRID;

interacts with

 TECHPRD;

interacts with

 TNFRSF1ABIOGRID;

interacts with

 TNFRSF1AHPRD;

interacts with

 TRIP11INTACT;

interacts with

 TSHRBIOGRID;

interacts with

 TSHRHPRD;

interacts with

 TSHZ1INTACT;

interacts with

 TYK2BIOGRID;

interacts with

 TYK2HPRD;

interacts with

 WDR7INTACT;

interacts with

 ZBTB40INTACT;

Metabolic Interaction   [Top]

Interaction Type

Interactor

Data Source

sequential catalysis

 IFNAR1REACTOME;

sequential catalysis

 JAK1REACTOME;

sequential catalysis

 STAT2REACTOME;

sequential catalysis

 TYK2REACTOME;

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 DOK2NCI_NATURE;

reacts with

 EBI3NCI_NATURE;

reacts with

 FESNCI_NATURE;

reacts with

 FYNNCI_NATURE;

reacts with

 GAB2NCI_NATURE;

reacts with

 HCKNCI_NATURE;

reacts with

 IFNAR1REACTOME;

reacts with

 IFNGNCI_NATURE;

reacts with

 IFNGREACTOME;

reacts with

 IFNGR1NCI_NATURE;

reacts with

 IFNGR1REACTOME;

reacts with

 IFNGR2REACTOME;

reacts with

 IL13RA1NCI_NATURE;

reacts with

 IL27NCI_NATURE;

reacts with

 IL27RANCI_NATURE;

reacts with

 IL2NCI_NATURE;

reacts with

 IL2REACTOME;

reacts with

 IL2RANCI_NATURE;

reacts with

 IL2RAREACTOME;

reacts with

 IL2RBNCI_NATURE;

reacts with

 IL2RBREACTOME;

reacts with

 IL2RGNCI_NATURE;

reacts with

 IL2RGREACTOME;

reacts with

 IL4NCI_NATURE;

reacts with

 IL4RNCI_NATURE;

reacts with

 IL6NCI_NATURE;

reacts with

 IL6RNCI_NATURE;

reacts with

 IL6STNCI_NATURE;

reacts with

 INPP5DNCI_NATURE;

reacts with

 IRS1NCI_NATURE;

reacts with

 IRS2NCI_NATURE;

reacts with

 JAK1NCI_NATURE;

reacts with

 JAK1REACTOME;

reacts with

 JAK2NCI_NATURE;

reacts with

 JAK2REACTOME;

reacts with

 JAK3NCI_NATURE;

reacts with

 JAK3REACTOME;

reacts with

 LCKNCI_NATURE;

reacts with

 PIK3CANCI_NATURE;

reacts with

 PIK3R1NCI_NATURE;

reacts with

 PTK2BNCI_NATURE;

reacts with

 PTPN11NCI_NATURE;

reacts with

 PTPN6NCI_NATURE;

reacts with

 SHC1NCI_NATURE;

reacts with

 SHC1REACTOME;

reacts with

 SOCS1NCI_NATURE;

reacts with

 SOCS2NCI_NATURE;

reacts with

 SOCS3NCI_NATURE;

reacts with

 SOS1NCI_NATURE;

reacts with

 STAT2REACTOME;

reacts with

 SYKNCI_NATURE;

reacts with

 SYKREACTOME;

reacts with

 TYK2REACTOME;

state change

 CISHNCI_NATURE;

state change

 IFNAR1REACTOME;

state change

 IFNGREACTOME;

state change

 IFNGR1REACTOME;

state change

 IFNGR2REACTOME;

state change

 IL2REACTOME;

state change

 IL2RAREACTOME;

state change

 IL2RBNCI_NATURE;

state change

 IL2RBREACTOME;

state change

 IL2RGNCI_NATURE;

state change

 IL2RGREACTOME;

state change

 JAK1NCI_NATURE;

state change

 JAK1REACTOME;

state change

 JAK2REACTOME;

state change

 JAK3NCI_NATURE;

state change

 JAK3REACTOME;

state change

 LCKNCI_NATURE;

state change

 PDGFRANCI_NATURE;

state change

 PTPN11NCI_NATURE;

state change

 PTPN6REACTOME;

state change

 RHOANCI_NATURE;

state change

 SOCS1NCI_NATURE;

state change

 SOCS3NCI_NATURE;

state change

 SOCS5NCI_NATURE;

state change

 STAT2REACTOME;

state change

 SYKREACTOME;

state change

 TYK2REACTOME;