| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3684 |
Name | ITGAM |
Synonymous | integrin, alpha M (complement component 3 receptor 3 subunit);ITGAM;integrin, alpha M (complement component 3 receptor 3 subunit) |
Definition | CD11 antigen-like family member B|CR-3 alpha chain|antigen CD11b (p170)|cell surface glycoprotein MAC-1 subunit alpha|integrin alpha-M|leukocyte adhesion receptor MO1|macrophage antigen alpha polypeptide|neutrophil adherence receptor alpha-M subunit |
Position | 16p11.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | CD11B(h) + factor H(h) <==> CD11B(h):factor H(h) (binding) | CD11B(h) + ATP --> CD11B(h){pS1142} + ADP (phosphorylation) | DC-SIGN(m.s.) + CD11B(h) <==> DC-SIGN(m.s.):CD11B(h) (binding) | CD66b(h) + CD11B(h) <==> CD66b(h):CD11B(h) (binding) | CD11B(h) + E-selectin(h) <==> CD11B(h):E-selectin(h) (binding) | CD11B(h) + proteinase 3(h) <==> CD11B(h):proteinase 3(h) (binding) | Fibrinogen(m.s.) + CD11B(h) <==> Fibrinogen(m.s.):CD11B(h) (binding) | CD11B(h) + elastase(h) <==> CD11B(h):elastase(h) (binding) | CD11B(h) + CD91(h) <==> CD11B(h):CD91(h) (binding) | CD11B(h) + CD91(h) <==> CD11B(h):CD91(h) (binding) | CD11B(h) + ATP --> CD11B(h){p} + ADP (phosphorylation) | CD11B(h) + ME491(h) <==> CD11B(h):ME491(h) (binding) | CD11B(h) + myeloperoxidase(h) <==> CD11B(h):myeloperoxidase(h) (binding) | CD11B(h) + PSA2(LEIIF) <==> CD11B(h):PSA2(LEIIF) (binding) | CD11B(h) + GP63(LEIME) <==> CD11B(h):GP63(LEIME) (binding) | iC3b(h) + CD11B(h) <==> iC3b(h):CD11B(h) (binding) | ITGAM(h) --> CD11B(h) (expression). | Fcgamma RIIIb(h) --> CD11B(h) (decrease of abundance) | TNF-alpha(h) --> CD11B(h) (increase of abundance) | fMLP-R(m.s.) --> CD11B(h) (increase of abundance) | TNF-alpha(m.s.) --> CD11B(h) (increase of abundance) | GM-CSF(m.s.) --> CD11B(h) (increase of abundance) | IL-18(m.s.) --> CD11B(h) (increase of abundance) | CD11B(h) + uPAR(h) <==> CD11B(h):uPAR(h) (binding) | CD11B(h) + IRAK1(m.s.) <==> CD11B(h):IRAK1(m.s.) (binding) | CD11B(h) + IRAK1(h) <==> CD11B(h):IRAK1(h) (binding) | icam1(h) + CD11B(h) <==> icam1(h):CD11B(h) (binding) | aup-1-isoformS(h) + CD11B(h) <==> aup-1-isoformS(h):CD11B(h) (binding) | CD11B(h) + ATP --> CD11B(h){pS1142} + ADP (phosphorylation) | CD11B(h) + ICAM-2(h) <==> CD11B(h):ICAM-2(h) (binding) | CD11B(h) + complement C3(h) <==> CD11B(h):complement C3(h) (binding) | beta2-integrin(h) + CD11B(h) <==> CD11B(h):beta2-integrin(h) (binding) | ITGAM(h) --> CD11B(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 86 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 240 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 391 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 469 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 692 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 696 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 734 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 801 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 880 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 900 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 911 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 940 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 946 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 978 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 993 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1021 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1044 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1050 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1075 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for ITGAM | ||