| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3684 |
Name | ITGAM |
Synonym | CD11B|CR3A|MAC-1|MAC1A|MO1A|SLEB6;integrin, alpha M (complement component 3 receptor 3 subunit);ITGAM;integrin, alpha M (complement component 3 receptor 3 subunit) |
Definition | CD11 antigen-like family member B|CR-3 alpha chain|antigen CD11b (p170)|cell surface glycoprotein MAC-1 subunit alpha|integrin alpha-M|leukocyte adhesion receptor MO1|macrophage antigen alpha polypeptide|neutrophil adherence receptor alpha-M subunit |
Position | 16p11.2 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Staphylococcus aureus infection;KEGG PATHWAY;hsa05150 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | Hematopoietic cell lineage;KEGG PATHWAY;hsa04640 |
Pathway | Cell adhesion molecules (CAMs);KEGG PATHWAY;hsa04514 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | Leishmaniasis;KEGG PATHWAY;hsa05140 |
Pathway | Phagosome;KEGG PATHWAY;hsa04145 |
Pathway | amb2 Integrin signaling;PID Curated;200108 |
Disease | Lupus erythematosus;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | Systemic lupus erythematous, association with susceptibility to, 6;OMIM |
Disease | IMMUNE;GAD |
Disease | Lupus Erythematosus, Systemic;GAD |
Disease | Pertussis;FunDO |
Disease | Leukemia;FunDO |
Disease | Melanoma;FunDO |
Disease | nephritis;GAD |
Disease | Systemic infection;FunDO |
Disease | Kidney failure;FunDO |
Disease | Systemic lupus erythematosus;NHGRI |
Disease | Yersinia infection;FunDO |
Disease | systemic lupus erythematosus;GAD |
Disease | Alzheimer's disease;FunDO |
Disease | Chronic obstructive airway disease;FunDO |
Disease | Thrombophilia;FunDO |
External Links | |
Links to Entrez Gene | 3684 |
Links to all GeneRIF Items | 3684 |
Links to iHOP | 3684 |
Sequence Information | |
Nucleotide Sequence | >3684 : length: 4745 TTTTCTGCCCTTCTTTGCTTTGGTGGCTTCCTTGTGGTTCCTCAGTGGTGCCTGCAACCC CTGGTTCACCTCCTTCCAGGTTCTGGCTCCTTCCAGCCATGGCTCTCAGAGTCCTTCTGT TAACAGCCTTGACCTTATGTCATGGGTTCAACTTGGACACTGAAAACGCAATGACCTTCC AAGAGAACGCAAGGGGCTTCGGGCAGAGCGTGGTCCAGCTTCAGGGATCCAGGGTGGTGG TTGGAGCCCCCCAGGAGATAGTGGCTGCCAACCAAAGGGGCAGCCTCTACCAGTGCGACT ACAGCACAGGCTCATGCGAGCCCATCCGCCTGCAGGTCCCCGTGGAGGCCGTGAACATGT CCCTGGGCCTGTCCCTGGCAGCCACCACCAGCCCCCCTCAGCTGCTGGCCTGTGGTCCCA CCGTGCACCAGACTTGCAGTGAGAACACGTATGTGAAAGGGCTCTGCTTCCTGTTTGGAT CCAACCTACGGCAGCAGCCCCAGAAGTTCCCAGAGGCCCTCCGAGGGTGTCCTCAAGAGG ATAGTGACATTGCCTTCTTGATTGATGGCTCTGGTAGCATCATCCCACATGACTTTCGGC GGATGAAGGAGTTTGTCTCAACTGTGATGGAGCAATTAAAAAAGTCCAAAACCTTGTTCT CTTTGATGCAGTACTCTGAAGAATTCCGGATTCACTTTACCTTCAAAGAGTTCCAGAACA ACCCTAACCCAAGATCACTGGTGAAGCCAATAACGCAGCTGCTTGGGCGGACACACACGG CCACGGGCATCCGCAAAGTGGTACGAGAGCTGTTTAACATCACCAACGGAGCCCGAAAGA ATGCCTTTAAGATCCTAGTTGTCATCACGGATGGAGAAAAGTTTGGCGATCCCTTGGGAT ATGAGGATGTCATCCCTGAGGCAGACAGAGAGGGAGTCATTCGCTACGTCATTGGGGTGG GAGATGCCTTCCGCAGTGAGAAATCCCGCCAAGAGCTTAATACCATCGCATCCAAGCCGC CTCGTGATCACGTGTTCCAGGTGAATAACTTTGAGGCTCTGAAGACCATTCAGAACCAGC TTCGGGAGAAGATCTTTGCGATCGAGGGTACTCAGACAGGAAGTAGCAGCTCCTTTGAGC ATGAGATGTCTCAGGAAGGCTTCAGCGCTGCCATCACCTCTAATGGCCCCTTGCTGAGCA CTGTGGGGAGCTATGACTGGGCTGGTGGAGTCTTTCTATATACATCAAAGGAGAAAAGCA CCTTCATCAACATGACCAGAGTGGATTCAGACATGAATGATGCTTACTTGGGTTATGCTG CCGCCATCATCTTACGGAACCGGGTGCAAAGCCTGGTTCTGGGGGCACCTCGATATCAGC ACATCGGCCTGGTAGCGATGTTCAGGCAGAACACTGGCATGTGGGAGTCCAACGCTAATG TCAAGGGCACCCAGATCGGCGCCTACTTCGGGGCCTCCCTCTGCTCCGTGGACGTGGACA GCAACGGCAGCACCGACCTGGTCCTCATCGGGGCCCCCCATTACTACGAGCAGACCCGAG GGGGCCAGGTGTCCGTGTGCCCCTTGCCCAGGGGGCAGAGGGCTCGGTGGCAGTGTGATG CTGTTCTCTACGGGGAGCAGGGCCAACCCTGGGGCCGCTTTGGGGCAGCCCTAACAGTGC TGGGGGACGTAAATGGGGACAAGCTGACGGACGTGGCCATTGGGGCCCCAGGAGAGGAGG ACAACCGGGGTGCTGTTTACCTGTTTCACGGAACCTCAGGATCTGGCATCAGCCCCTCCC ATAGCCAGCGGATAGCAGGCTCCAAGCTCTCTCCCAGGCTCCAGTATTTTGGTCAGTCAC TGAGTGGGGGCCAGGACCTCACAATGGATGGACTGGTAGACCTGACTGTAGGAGCCCAGG GGCACGTGCTGCTGCTCAGGTCCCAGCCAGTACTGAGAGTCAAGGCAATCATGGAGTTCA ATCCCAGGGAAGTGGCAAGGAATGTATTTGAGTGTAATGATCAGGTGGTGAAAGGCAAGG AAGCCGGAGAGGTCAGAGTCTGCCTCCATGTCCAGAAGAGCACACGGGATCGGCTAAGAG AAGGACAGATCCAGAGTGTTGTGACTTATGACCTGGCTCTGGACTCCGGCCGCCCACATT CCCGCGCCGTCTTCAATGAGACAAAGAACAGCACACGCAGACAGACACAGGTCTTGGGGC TGACCCAGACTTGTGAGACCCTGAAACTACAGTTGCCGAATTGCATCGAGGACCCAGTGA GCCCCATTGTGCTGCGCCTGAACTTCTCTCTGGTGGGAACGCCATTGTCTGCTTTCGGGA ACCTCCGGCCAGTGCTGGCGGAGGATGCTCAGAGACTCTTCACAGCCTTGTTTCCCTTTG AGAAGAATTGTGGCAATGACAACATCTGCCAGGATGACCTCAGCATCACCTTCAGTTTCA TGAGCCTGGACTGCCTCGTGGTGGGTGGGCCCCGGGAGTTCAACGTGACAGTGACTGTGA GAAATGATGGTGAGGACTCCTACAGGACACAGGTCACCTTCTTCTTCCCGCTTGACCTGT CCTACCGGAAGGTGTCCACGCTCCAGAACCAGCGCTCACAGCGATCCTGGCGCCTGGCCT GTGAGTCTGCCTCCTCCACCGAAGTGTCTGGGGCCTTGAAGAGCACCAGCTGCAGCATAA ACCACCCCATCTTCCCGGAAAACTCAGAGGTCACCTTTAATATCACGTTTGATGTAGACT CTAAGGCTTCCCTTGGAAACAAACTGCTCCTCAAGGCCAATGTGACCAGTGAGAACAACA TGCCCAGAACCAACAAAACCGAATTCCAACTGGAGCTGCCGGTGAAATATGCTGTCTACA TGGTGGTCACCAGCCATGGGGTCTCCACTAAATATCTCAACTTCACGGCCTCAGAGAATA CCAGTCGGGTCATGCAGCATCAATATCAGGTCAGCAACCTGGGGCAGAGGAGCCTCCCCA TCAGCCTGGTGTTCTTGGTGCCCGTCCGGCTGAACCAGACTGTCATATGGGACCGCCCCC AGGTCACCTTCTCCGAGAACCTCTCGAGTACGTGCCACACCAAGGAGCGCTTGCCCTCTC ACTCCGACTTTCTGGCTGAGCTTCGGAAGGCCCCCGTGGTGAACTGCTCCATCGCTGTCT GCCAGAGAATCCAGTGTGACATCCCGTTCTTTGGCATCCAGGAAGAATTCAATGCTACCC TCAAAGGCAACCTCTCGTTTGACTGGTACATCAAGACCTCGCATAACCACCTCCTGATCG TGAGCACAGCTGAGATCTTGTTTAACGATTCCGTGTTCACCCTGCTGCCGGGACAGGGGG CGTTTGTGAGGTCCCAGACGGAGACCAAAGTGGAGCCGTTCGAGGTCCCCAACCCCCTGC CGCTCATCGTGGGCAGCTCTGTCGGGGGACTGCTGCTCCTGGCCCTCATCACCGCCGCGC TGTACAAGCTCGGCTTCTTCAAGCGGCAATACAAGGACATGATGAGTGAAGGGGGTCCCC CGGGGGCCGAACCCCAGTAGCGGCTCCTTCCCGACAGAGCTGCCTCTCGGTGGCCAGCAG GACTCTGCCCAGACCACACGTAGCCCCCAGGCTGCTGGACACGTCGGACAGCGAAGTATC CCCGACAGGACGGGCTTGGGCTTCCATTTGTGTGTGTGCAAGTGTGTATGTGCGTGTGTG CAAGTGTCTGTGTGCAAGTGTGTGCACATGTGTGCGTGTGCGTGCATGTGCACTTGCACG CCCATGTGTGAGTGTGTGCAAGTATGTGAGTGTGTCCAAGTGTGTGTGCGTGTGTCCATG TGTGTGCAAGTGTGTGCATGTGTGCGAGTGTGTGCATGTGTGTGCTCAGGGGCGTGTGGC TCACGTGTGTGACTCAGATGTCTCTGGCGTGTGGGTAGGTGACGGCAGCGTAGCCTCTCC GGCAGAAGGGAACTGCCTGGGCTCCCTTGTGCGTGGGTGAAGCCGCTGCTGGGTTTTCCT CCGGGAGAGGGGACGGTCAATCCTGTGGGTGAAGACAGAGGGAAACACAGCAGCTTCTCT CCACTGAAAGAAGTGGGACTTCCCGTCGCCTGCGAGCCTGCGGCCTGCTGGAGCCTGCGC AGCTTGGATGGAGACTCCATGAGAAGCCGTGGGTGGAACCAGGAACCTCCTCCACACCAG CGCTGATGCCCAATAAAGATGCCCACTGAGGAATGATGAAGCTTCCTTTCTGGATTCATT TATTATTTCAATGTGACTTTAATTTTTTGGATGGATAAGCTTGTCTATGGTACAAAAATC ACAAGGCATTCAAGTGTACAGTGAAAAGTCTCCCTTTCCAGATATTCAAGTCACCTCCTT AAAGGTAGTCAAGATTGTGTTTTGAGGTTTCCTTCAGACAGATTCCAGGCGATGTGCAAG TGTATGCACGTGTGCACACACACCACACATACACACACACAAGCTTTTTTACACAAATGG TAGCATACTTTATATTGGTCTGTATCTTGCTTTTTTTCACCAATATTTCTCAGACATCGG TTCATATTAAGACATAAATTACTTTTTCATTCTTTTATACCGCTGCATAGTATTCCATTG TGTGAGTGTACCATAATGTATTTAACCAGTCTTCTTTTGATATACTATTTTCATTCTCTT GTTATTGCATCAATGCTGAGTTAATAAATCAAATATATGTCATTTTTGCATATATGTAAG GATAA |
Protein Sequence | >3684 : length: 1153 MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQR GSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVK GLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQL KKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFN ITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQEL NTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAIT SNGPLLSTVGSYDWAGGVFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLV LGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAP HYYEQTRGGQVSVCPLPRGQRARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVA IGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLV DLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQK STRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLP NCIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDD LSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRS QRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKA NVTSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSN LGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPV VNCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVF TLLPGQGAFVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKD MMSEGGPPGAEPQ |