Entrez Gene

Basic Information
Gene ID	3636
Name	INPPL1
Synonymous	inositol polyphosphate phosphatase-like 1;INPPL1;inositol polyphosphate phosphatase-like 1
Definition	51C protein\|INPPL-1\|SH2 domain-containing inositol 5'-phosphatase 2\|SH2 domain-containing inositol-5'-phosphatase 2\|SHIP-2\|phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2\|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2\|protein 51C
Position	11q13
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
SHIP2-isoform1(h) + ATP --> SHIP2-isoform1(h){pY} + ADP (phosphorylation)
SHIP2-isoform1(h) + CAP(h) <==> SHIP2-isoform1(h):CAP(h) (binding)
c-Cbl(ha) + SHIP2-isoform1(h) <==> c-Cbl(ha):SHIP2-isoform1(h) (binding)
InsR(h){p} + SHIP2-isoform1(h) <==> InsR(h){p}:SHIP2-isoform1(h) (binding)
Shc-1(mo) + SHIP2-isoform1(h) <==> Shc-1(mo):SHIP2-isoform1(h) (binding)
EGFR(mo) + SHIP2-isoform1(h) <==> EGFR(mo):SHIP2-isoform1(h) (binding)
INPPL1(h) --> SHIP2-isoform1(h) (expression).
Ins(1,3,4)P3 --SHIP2-isoform1(h)--> Ins(3,4)P2 + p (dephosphorylation)
INPPL1(h) --> SHIP2-isoform2(h) (expression).
SHIP2(h) + JIP1(r) <==> SHIP2(h):JIP1(r) (binding)
SHIP2(h) --> c-Jun(m.s.){p} (increase of phosphorylation)
SHIP2(h) + MLK3(m.s.) + JIP1(r) <==> SHIP2(h):MLK3(m.s.):JIP1(r) (binding)
SHIP2(h) + JNK1(m.s.) + JIP1(r) <==> SHIP2(h):JNK1(m.s.):JIP1(r) (binding)
JIP1(r) + MLK3(m.s.) + SHIP2(h) + JNK1(m.s.){p} <==> JIP1(r):MLK3(m.s.):SHIP2(h):JNK1(m.s.){p} (binding)
JIP1(r) + MKK7(m.s.) + SHIP2(h) <==> JIP1(r):MKK7(m.s.):SHIP2(h) (binding)
JIP1(h) + SHIP2(h) <==> JIP1(h):SHIP2(h) (binding)
INPPL1(h) --> SHIP2(h) (expression).

Post Translational Modification [Top]
	There is no record for INPPL1

Transcription Factors [Top]