| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3636 |
Name | INPPL1 |
Synonym | OPSMD|SHIP2;inositol polyphosphate phosphatase-like 1;INPPL1;inositol polyphosphate phosphatase-like 1 |
Definition | 51C protein|INPPL-1|SH2 domain-containing inositol 5'-phosphatase 2|SH2 domain-containing inositol-5'-phosphatase 2|SHIP-2|phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2|protein 51C |
Position | 11q13 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | PI3 kinase pathway;PANTHER;P00048 |
Pathway | superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism;BioCyc;PWY-6358 |
Pathway | Phosphatidylinositol signaling system;KEGG PATHWAY;hsa04070 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian);BioCyc;PWY-6362 |
Pathway | Inositol phosphate metabolism;KEGG PATHWAY;hsa00562 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | 3-phosphoinositide degradation;BioCyc;PWY-6368 |
Pathway | Insulin/IGF pathway-protein kinase B signaling cascade;PANTHER;P00033 |
Pathway | D-myo-inositol (1,4,5)-trisphosphate degradation;BioCyc;PWY-6363 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | D-myo-inositol (1,3,4)-trisphosphate biosynthesis;BioCyc;PWY-6364 |
Pathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway;PID BioCarta;100137 |
Pathway | EPHA2 forward signaling;PID Curated;200185 |
Disease | Embryoma;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | Carcinoma;FunDO |
Disease | Hypertension;FunDO |
Disease | Glucose intolerance;FunDO |
Disease | Neoplasm metastasis;FunDO |
External Links | |
Links to Entrez Gene | 3636 |
Links to all GeneRIF Items | 3636 |
Links to iHOP | 3636 |
Sequence Information | |
Nucleotide Sequence | >3636 : length: 5063 GGGAAGGGGGCGCCGGAGCAGCCCGGGAGGTGGGGGTCTGCGTGCGGCGGCCGGGATCCC GGGAGGGAACTTTCTACTAGACGGGCCAGGGATCCTCCTGGCTTCGGACTGCTGAACCCC CTCAAGGCCCGGCCTGCGGGTGTGGGGGGTGGTGCTGGGGAACTTGGCCGAGAGGGGGAA GGGCTCTGCGGGGCTGGGAGGGGCTGCGTGAGAGGCTCGAGAACGTCGCACCTCGTCTGG GCCCCCCGCCAGATTGAGGCCGGCGCTGCAGGCAGCGGCGGCTGCGCGGTGAACGAGGCG GCCTGCGCGGCGGAGTGCTGAGTCCCGATCCCCGGCTCTGTCCGGCCCACGGATCCTCAA GCCCGGGCCCCGGGCCCGGCCCCAGCCTCAGCCCTGAGCGTCTCGGGGCGGATGGCGCGG GGCGGCGGGGGCGGGCGGTGCTGAGCCCTGCGCGGGCCATGGCCTCGGCCTGCGGGGCGC CGGGCCCGGGGGGCGCCCTGGGCAGCCAGGCCCCCTCCTGGTACCACCGCGACCTGAGCC GGGCGGCCGCGGAGGAGCTGCTGGCCCGGGCGGGCCGCGATGGCAGCTTCCTGGTCCGAG ACAGCGAGAGCGTGGCGGGGGCCTTCGCGCTCTGCGTCCTGTATCAGAAGCATGTGCACA CGTATCGCATTCTGCCTGATGGAGAAGATTTCTTGGCTGTGCAGACCTCGCAGGGTGTGC CTGTGCGCCGCTTCCAGACCCTGGGTGAGCTCATCGGCCTGTACGCCCAGCCCAACCAGG GCCTTGTGTGCGCCCTGCTTCTTCCTGTAGAGGGTGAGCGAGAGCCGGACCCACCGGATG ACCGGGATGCCTCAGATGGGGAGGATGAGAAGCCCCCGCTGCCCCCGCGCTCTGGCTCCA CCAGCATTTCTGCCCCCACTGGGCCCAGCAGTCCCCTGCCAGCTCCTGAGACTCCCACAG CTCCAGCTGCTGAGAGGGATGGGGCAGAGGTGCTGGGACAGGTCAGCAGGACCTCCACTG ACTTCTTAACCCCTCCCCAAAGTGCTCCCAATGGGCTGAGCACCGTCTCGCACGACTACC TGAAAGGCAGCTATGGGCTGGACCTGGAAGCTGTGAGGGGTGGAGCCAGCCACCTGCCCC ACCTCACCCGTACCCTCGCTACCTCATGCCGGAGGCTGCACAGTGAGGTGGACAAGGTCC TGTCAGGCCTGGAGATCCTGTCCAAGGTGTTTGACCAGCAGAGCTCGCCCATGGTGACCC GCCTTTTGCAGCAGCAGAACCTGCCACAGACAGGGGAGCAGGAACTAGAGAGCCTGGTGC TGAAGCTGTCAGTGCTAAAGGACTTCCTGTCAGGCATCCAGAAGAAGGCCCTGAAGGCCC TACAGGACATGAGCTCCACAGCACCCCCAGCTCCGCAGCCATCCACACGTAAGGCCAAGA CCATCCCCGTGCAGGCCTTTGAGGTGAAGCTAGATGTGACCCTGGGTGACCTGACCAAGA TTGGGAAGTCACAGAAGTTCACGCTGAGCGTGGATGTGGAGGGTGGGCGGCTGGTGCTGC TGCGGAGACAGCGGGACTCCCAGGAGGACTGGACCACCTTCACGCACGACCGCATCCGCC AGCTCATTAAGTCCCAGCGTGTCCAGAACAAGCTGGGTGTTGTGTTTGAGAAGGAGAAGG ACCGGACTCAGCGCAAGGACTTCATCTTTGTCAGTGCCCGGAAGCGGGAGGCCTTCTGCC AGCTGTTGCAGCTCATGAAGAACAAGCACTCCAAGCAGGACGAGCCCGACATGATCTCAG TCTTCATAGGCACCTGGAACATGGGAAGTGTACCACCTCCAAAAAACGTGACATCCTGGT TCACATCGAAGGGTCTGGGGAAGACCCTGGACGAGGTCACAGTGACCATACCCCATGACA TCTATGTCTTTGGGACCCAGGAGAACTCAGTGGGCGACCGCGAGTGGCTGGACCTACTGC GCGGGGGCCTCAAGGAGCTTACGGATCTGGATTACCGCCCGATTGCCATGCAATCACTGT GGAATATCAAGGTGGCAGTGCTGGTCAAGCCAGAGCACGAGAACCGTATCAGCCATGTCA GTACGTCCAGTGTGAAGACTGGCATCGCCAACACCCTGGGGAACAAGGGGGCTGTGGGCG TCTCCTTCATGTTTAATGGCACCTCATTTGGCTTTGTGAATTGTCACCTCACCTCGGGAA ATGAGAAGACGGCTCGGAGGAACCAAAACTACTTGGACATCCTGCGGCTGCTCTCGCTGG GCGACCGGCAGCTCAATGCCTTTGACATCTCTCTGCGTTTCACACACCTCTTCTGGTTTG GGGACCTCAACTACCGCCTGGACATGGATATCCAGGAGATCCTGAACTACATCAGCAGGA AAGAGTTTGAGCCCCTCCTCAGGGTGGACCAGCTCAACCTGGAGCGGGAGAAGCACAAGG TCTTCCTTCGATTCAGTGAGGAGGAGATCTCCTTCCCACCCACCTACCGCTATGAGCGGG GTTCCCGGGACACATATGCCTGGCACAAGCAGAAGCCAACTGGGGTCCGGACCAATGTGC CCTCATGGTGTGACCGGATTCTGTGGAAATCCTACCCTGAAACTCACATCATCTGCAATT CTTATGGTTGCACTGATGACATCGTCACCAGCGACCATTCCCCCGTGTTTGGGACATTTG AGGTTGGAGTTACCTCCCAGTTCATCTCCAAGAAAGGGCTCTCAAAGACTTCAGACCAGG CCTACATTGAGTTTGAGAGCATCGAGGCCATTGTGAAGACAGCCAGCCGCACCAAGTTCT TCATCGAGTTCTACTCTACCTGCCTGGAGGAATACAAGAAGAGCTTTGAGAATGATGCCC AGAGCAGTGACAACATCAACTTCCTCAAAGTGCAGTGGTCTTCACGCCAGCTGCCCACGC TCAAACCAATTCTGGCTGATATCGAGTACCTGCAGGACCAGCACCTCCTGCTCACAGTCA AGTCCATGGATGGCTATGAATCCTATGGGGAGTGTGTGGTTGCACTCAAATCCATGATCG GCAGCACGGCCCAACAGTTCCTGACCTTCCTATCCCACCGTGGCGAGGAGACAGGCAATA TCAGAGGCTCCATGAAGGTGCGGGTGCCCACGGAGCGCCTGGGCACCCGTGAGCGGCTCT ACGAGTGGATCAGCATTGATAAGGATGAGGCAGGAGCAAAGAGCAAAGCCCCCTCTGTGT CCCGAGGGAGCCAGGAGCCCAGGTCAGGGAGCCGCAAGCCAGCCTTCACAGAGGCCTCCT GCCCGCTCTCCAGGTTATTTGAAGAACCAGAGAAACCGCCACCAACGGGGAGGCCCCCAG CCCCACCCCGAGCAGCTCCCCGGGAGGAGCCCTTGACCCCCAGGTTGAAGCCAGAGGGAG CTCCTGAACCAGAAGGGGTGGCGGCCCCCCCACCCAAGAACAGCTTCAATAACCCTGCCT ACTACGTCCTTGAAGGGGTCCCGCACCAGCTGCTGCCCCCGGAGCCACCCTCGCCTGCCA GGGCCCCTGTCCCATCTGCCACCAAGAACAAAGTGGCCATTACAGTGCCTGCTCCACAGC TTGGGCACCACCGGCACCCTCGTGTGGGAGAGGGGAGTTCTTCAGATGAGGAGTCTGGAG GCACACTGCCCCCTCCAGACTTTCCACCTCCACCACTGCCGGACTCAGCCATCTTCCTGC CCCCCAGCCTGGATCCTTTACCAGGGCCAGTGGTCCGGGGCCGTGGTGGGGCTGAGGCCC GTGGCCCACCACCTCCCAAGGCCCATCCAAGGCCTCCACTGCCCCCAGGCCCCTCACCAG CCAGCACTTTCCTGGGGGAAGTGGCCAGTGGGGATGACCGGTCCTGCTCGGTGCTGCAGA TGGCCAAGACGCTGAGCGAGGTGGACTATGCCCCTGCTGGGCCTGCACGCTCAGCGCTCC TCCCAGGCCCCCTGGAGCTGCAGCCCCCCCGGGGACTGCCCTCGGACTATGGCCGGCCCC TCAGCTTCCCTCCACCCCGCATCCGGGAGAGCATCCAGGAAGACCTGGCAGAGGAGGCTC CGTGCCTGCAGGGCGGGCGGGCCAGCGGGCTGGGCGAGGCAGGCATGAGTGCCTGGCTGC GGGCCATCGGCTTGGAGCGCTATGAGGAGGGCCTGGTGCATAATGGCTGGGACGACCTGG AGTTTCTCAGTGACATCACCGAGGAGGACTTGGAGGAGGCTGGGGTGCAGGACCCGGCTC ACAAGCGCCTCCTTCTGGACACCCTGCAGCTCAGCAAGTGATAGCGGAGGCACCACGAAG CTGTGAACTCAGAGCCCCTCCCTGCTACCAAGGCCCAGCTATGGCCCCAGGGTTGAAAAG TTATGAGGGTCAGGGCAGTATCTCTCTGCCTATTTATTGGGGTGCCTATTTATTGGGGAT CTGCATTCCCCGCTGCCCAATCATTTGCAATGCCCTAATTAGGGCATCCTGCCCCTCGCC TTTTAGGCTCAGGACGGAAGGTCAGTTGCCATGGTTACCGAGGACCCTGGTTACTCTGGT GCTGTCCTGTTTTACTGGACCCCGCCTCCCAGCCCCAGGGGTGCCTGTGGGGGTCCATTT GGGTACGTCTGGGCCCCCACTTTCACCAGTTTCTGCGGCCTTCCACCGGGCCTGAACCAC AGCGGAGGAGCTCCGCTAAGACCTCCCCACCCCCGCTGGGGGTGGGGGCGGGTGTCCGTC CGGAAATGAAGGAATAGCCCGAGGACCGGGCTGGGGTTTATTTAAACTGTTCTGTGTGGG TCTGGGGAGGGAGAGCACCTTAATATTATTGGGGTTGGTTGGGGTGGGGCAGGATCTCAG CCATAAAGTGCCAGTTTGCTTAGTTCTCACTGTCTCCTGGTCTGTGCTGCCCTGCTCTGG GGATGCACGGCGGCAGGGTGGGGGAGGGAGGTTCCTCGCAGGTCTCAGCCCGGGACAGGG TCTTGCAAGCAGCCTCCTGGGCAGTCGTAAGGGTTGCGGCGTGATGTCTTCAATAAATTA AGTTTTATTTGGATTGAGTAAAA |
Protein Sequence | >3636 : length: 1280 MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAERDGAEVLG QVSRTSTDFLTPPQSAPNGLSTVSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRL HSEVDKVLSGLEILSKVFDQQSSPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGI QKKALKALQDMSSTAPPAPQPSTRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDV EGGRLVLLRRQRDSQEDWTTFTHDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSA RKREAFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEV TVTIPHDIYVFGTQENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEH ENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLD ILRLLSLGDRQLNAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLN LEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYP ETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVK TASRTKFFIEFYSTCLEEYKKSFENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQD QHLLLTVKSMDGYESYGECVVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTER LGTRERLYEWISIDKDEAGAKSKAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKP PPTGRPPAPPRAAPREEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLP PEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPL PDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDD RSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQ EDLAEEAPCLQGGRASGLGEAGMSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEE AGVQDPAHKRLLLDTLQLSK |