| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3577 |
Name | CXCR1 |
Synonymous | chemokine (C-X-C motif) receptor 1;CXCR1;chemokine (C-X-C motif) receptor 1 |
Definition | C-X-C chemokine receptor type 1|CXC-R1|CXCR-1|IL-8 receptor type 1|IL-8R A|high affinity interleukin-8 receptor A|interleukin 8 receptor, alpha|interleukin-8 receptor type 1|interleukin-8 receptor type A |
Position | 2q35 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | IL-8(h) + CXCR1(h) <==> IL-8(h):CXCR1(h) (binding) | CXCR1(h) --> PLCbeta3(r) (activation; phosphorylation) | CXCR1(h) + ATP --> CXCR1(h){p} + ADP (phosphorylation) | CXCR1(h) --> G-alpha-14(m) (activation) | CXCR1(h) --> G-alpha-15(m) (activation) | CXCR1(h) --> G-alpha-15(h) (activation) | IL-8(rb) + CXCR1(h) <==> IL-8(rb):CXCR1(h) (binding) | CXCR1(h) + beta-arrestin2(r) <==> CXCR1(h):beta-arrestin2(r) (binding) | CXCR1(h) + beta-adaptin 2(r) <==> CXCR1(h):beta-adaptin 2(r) (binding) | CXCR1(h) + transferrin(v.s.) <==> CXCR1(h):transferrin(v.s.) (binding) | CXCR1(h) + G-alpha-i2(h) <==> CXCR1(h):G-alpha-i2(h) (binding) | CXCR1(h) + RGS12(h) <==> CXCR1(h):RGS12(h) (binding) | IL8RA(h) --> CXCR1(h) (expression). | beta-arrestin1(r) --/ CXCR1(h) (inhibition; translocation) | betaARK-1(r) --/ CXCR1(h) (inhibition; translocation) | dynamin1(r) --/ CXCR1(h) (inhibition; translocation) | NAP-2(m.s.) --/ CXCR1(h) (decrease of abundance) | CTAP-III(m.s.) --/ CXCR1(h) (decrease of abundance) | NAP-2-CTF(m.s.) --/ CXCR1(h) (decrease of abundance) | CXCR1(h) + IL-8(h) <==> CXCR1(h):IL-8(h) (binding) | CXCR1(h) + ATP --> CXCR1(h){p} + ADP (phosphorylation) | CXCR1(h) --> ERK1(r){p} (increase of phosphorylation) | CXCR1(h) --> ERK2(r){p} (increase of phosphorylation) | IL8RA(h) --> CXCR1(h) (expression). |
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Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 3 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 16 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for CXCR1 | ||