| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3572 |
Name | IL6ST |
Synonymous | interleukin 6 signal transducer;IL6ST;interleukin 6 signal transducer |
Definition | CD130 antigen|IL-6 receptor subunit beta|IL-6R subunit beta|gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form|gp130, oncostatin M receptor|interleukin receptor beta chain|interleukin-6 receptor subunit beta|membrane glycoprotein 130 |
Position | 5q11.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | 2 IL-6(h):IL-6R(h) + 2 gp130(h) <==> (IL-6(h):IL-6R(h):gp130(h))2 (binding) | uPAR(h) + gp130(h) <==> uPAR(h):gp130(h) (binding) | gp130(h) + ErbB2(h) <==> gp130(h):ErbB2(h) (binding) | gp130(h) + ErbB3(h) <==> gp130(h):ErbB3(h) (binding) | gp130(h) + ATP --> gp130(h){pY} + ADP (phosphorylation) | gp130(h) + LIFR(h) <==> gp130(h):LIFR(h) (binding) | SHP-2(h) + gp130(h) <==> SHP-2(h):gp130(h) (binding) | gp130(h) + STAT3-isoform1(m) <==> gp130(h):STAT3-isoform1(m) (binding) | gp130(h) + SHP-2(mo) <==> gp130(h):SHP-2(mo) (binding) | PKCdelta(m) + gp130(h) <==> PKCdelta(m):gp130(h) (binding) | STAT3(h) + gp130(h) <==> STAT3(h):gp130(h) (binding) | gp130(h) + Grb-2(h) <==> gp130(h):Grb-2(h) (binding) | gp130(h) + NDP-Gly --> gp130(h){gly} + NMP (glycosylation) | IL6ST(h) --> gp130(h) (expression). | gp130-isoform1(h) + ATP --> gp130-isoform1(h){pY} + ADP (phosphorylation) | gp130-isoform1(h) --> STAT3(h){p} (increase of phosphorylation) | gp130-isoform1(h) --> SHP-2(m){pY} (increase of phosphorylation) | gp130-isoform1(h) + IL-6R-short(h) <==> gp130-isoform1(h):IL-6R-short(h) (binding) | gp130-isoform1(h) + IL-6(h) <==> gp130-isoform1(h):IL-6(h) (binding) | 2 gp130-isoform1(h) <==> (gp130-isoform1(h))2 (binding; oligomerization) | LIFR(h) + gp130-isoform1(h) <==> LIFR(h):gp130-isoform1(h) (binding) | gp130-isoform1(h) + ATP --PKCdelta(m.s.){p}--> gp130-isoform1(h){p} + ADP (phosphorylation) | Vav(h) + gp130-isoform1(h) <==> Vav(h):gp130-isoform1(h) (binding) | Grb-2(h) + gp130-isoform1(h) <==> Grb-2(h):gp130-isoform1(h) (binding) | IL6ST(h) --> gp130-isoform1(h) (expression). | IL6ST(h) --> gp130-isoform2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 43 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 83 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 131 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 157 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 227 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 379 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 383 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 553 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 564 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 667 | Phosphoserine. | Swiss-Prot 53.0 | 782 | Phosphoserine. | Swiss-Prot 53.0 | 820 | Phosphoserine. | Swiss-Prot 53.0 | 829 | Phosphoserine. | Swiss-Prot 53.0 | 767 | Phosphotyrosine | 8612579;10661409 | Phospho.ELM 6.0 | 683 | Phosphotyrosine (JAK1;JAK2) | 10661409 | Phospho.ELM 6.0 | 814 | Phosphotyrosine | 8612579;10661409 | Phospho.ELM 6.0 | 905 | Phosphotyrosine | 8612579;10661409 | Phospho.ELM 6.0 | 915 | Phosphotyrosine | 8612579;10661409 | Phospho.ELM 6.0 | 759 | Phosphotyrosine | 8934572;9505191 | Phospho.ELM 6.0 | 890 | Phosphothreonine (PKC delta) | 12361954 | Phospho.ELM 6.0 | 782 | Phosphoserine | 15786731;10811661 | Phospho.ELM 6.0 | 667 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 820 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 829 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr5 |
Promoter: 55326020 - 55328020 | Agilent_014791 |
chr5 |
Promoter: 55326020 - 55328020 | GSE27584 |
chr5 |
Promoter: 55326020 - 55328020 | GSE27584 |