| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 351 |
Name | APP |
Synonymous | amyloid beta (A4) precursor protein;APP;amyloid beta (A4) precursor protein |
Definition | alzheimer disease amyloid protein|amyloid beta A4 protein|beta-amyloid peptide|beta-amyloid peptide(1-40)|beta-amyloid peptide(1-42)|cerebral vascular amyloid peptide|peptidase nexin-II|preA4|protease nexin-II |
Position | 21q21.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | APP(h) + PS1(h) <==> APP(h):PS1(h) (binding) | APP(h) + PS2(h) <==> APP(h):PS2(h) (binding) | APP(h) + ERAB(h) <==> APP(h):ERAB(h) (binding) | Nicastrin(h) + APP(h) <==> Nicastrin(h):APP(h) (binding) | APP(h) --Asp2(h)--> APP-C99(h) + APPp100(h) (processing) | APP(h) + JIP1(h) <==> APP(h):JIP1(h) (binding) | APP(h) + Fe65(r) <==> APP(h):Fe65(r) (binding; transactivation) | APP(h) + Fe65(r) + Tip60(r) <==> APP(h):Fe65(r):Tip60(r) (binding; transactivation) | APP(h) + Fe65(r) + Tip60(h) <==> APP(h):Fe65(r):Tip60(h) (binding; transactivation) | APP(h) + Fe65(h) + Mena(h) <==> APP(h):Fe65(h):Mena(h) (binding) | APP(h) + Mena(h) <==> APP(h):Mena(h) (binding) | APP(h) + CD91(h) <==> APP(h):CD91(h) (binding) | APP(h) --adam10(h)--> alphaAPPs(h) + APP-C83(h) (processing) | APP(h) --adam10(b)--> alphaAPPs(h) + APP-C83(h) (processing) | Grb-2(m.s.) + APP(h) <==> Grb-2(m.s.):APP(h) (binding) | APP(h) + CRT(h) <==> APP(h):CRT(h) (binding) | APP(h) + X11(r) <==> APP(h):X11(r) (binding) | APP(h) + Mint-2(r) <==> APP(h):Mint-2(r) (binding) | APP(h) + Apba3(r) <==> APP(h):Apba3(r) (binding) | APP(h) + ATP --> APP(h){pT668} + ADP (phosphorylation) | APP(h) --> alphaAPPs(h) + protein remnants (cleavage) | APP(h) --> Abeta40(h) (activation) | APP(h) --> Abeta38(h) (activation) | APP(h) --> Abeta42(h) (activation) | APP(h) + FKBP12(h) <==> APP(h):FKBP12(h) (binding) | APP(h) + p53(h) <==> APP(h):p53(h) (binding) | APP(h) + flotillin-1(h) <==> APP(h):flotillin-1(h) (binding) | APP(h) --> APP-C99(h) + protein remnants (cleavage) | APP(h) --> APP-C83(h) + protein remnants (cleavage) | APP(h) + Asp(h) <==> APP(h):Asp(h) (binding) | APP(h) + Fe65(m.s.) <==> APP(h):Fe65(m.s.) (binding) | APP(h) + ERAB(m.s.) <==> APP(h):ERAB(m.s.) (binding) | APP(h) --> APP(h) (translocation) | APP(h) --Asp2(h)--> APPp100(h) + protein remnants (cleavage) | APP(h) --Asp2(h)--> APP-C89(h) + protein remnants (cleavage) | APP(h) --> APP(h) (expression). | AICD59(h) --> APP(h) (transactivation) | APP(h) --> APP(h) (translocation) | GM-CSFRalpha(h) --/ APP(h) (decrease of abundance) | APP695(h) + X11(h) <==> APP695(h):X11(h) (binding) | APP695(h) + CD91(h) <==> APP695(h):CD91(h) (binding) | APP695(h) + ATP --Cdk5(r)--> APP695(h){pT668} + ADP (phosphorylation) | Fe65(h) + APP695(h) <==> APP695(h):Fe65(h) (binding) | APP695(h) + FE65L1(h) <==> APP695(h):FE65L1(h) (binding) | FE65L2(h) + APP695(h) <==> APP695(h):FE65L2(h) (binding) | APP695(h) + X11L(h) <==> APP695(h):X11L(h) (binding) | APP695(h) + X11L(h) <==> APP695(h):X11L(h) (binding) | APP695(h) + CRT(h) <==> APP695(h):CRT(h) (binding) | APP695(h) + DAB555(m) <==> APP695(h):DAB555(m) (binding) | APP695(h) + Fe65(r) <==> APP695(h):Fe65(r) (binding) | APP695(h) + Fibulin 1-C(h) <==> APP695(h):Fibulin 1-C(h) (binding) | APP695(h) + Fibulin 1(mo) <==> APP695(h):Fibulin 1(mo) (binding) | APP695(h) + X11(r) <==> APP695(h):X11(r) (binding) | APP695(h) + Mint-2(r) <==> APP695(h):Mint-2(r) (binding) | APP695(h) + Apba3(r) <==> APP695(h):Apba3(r) (binding) | APP695(h) --> AICD(h) (activation) | APP695(h) --> Abeta40(h) (activation) | APP695(h) + F-Spondin(h) <==> APP695(h):F-Spondin(h) (binding) | APP695(h) --Asp2(m.s.)--> APP-C99(h) + protein remnants (cleavage) | APP695(h) --Asp2(m.s.)--> APP-C89(h) + protein remnants (cleavage) | 14-3-3gamma(h) + APP695(h) <==> 14-3-3gamma(h):APP695(h) (binding) | 14-3-3eta(h) + APP695(h) <==> 14-3-3eta(h):APP695(h) (binding) | APP695(h) --> sAPP695alpha(h) + protein remnants (cleavage) | APP695(h) --> Abeta(h) (activation) | APP695(h) --> Abeta42(h) (activation) | APP695(h) --> APP-C83(h) + protein remnants (cleavage) | APP695(h) --> APP-C99(h) + protein remnants (cleavage) | APP695(h) --> sAPP695beta(h) + protein remnants (cleavage) | APP695(h) --> APP-P3(h) (activation) | APP695(h) + Fe65(m) <==> APP695(h):Fe65(m) (binding) | APP695(h) --Asp2(m.s.)--> APP-CTFbeta(h) + protein remnants (cleavage) | APP695(h) --Asp2(m.s.)--> sAPP695beta(h) + APP-CTFbeta(h) (cleavage) | APP695(h) --MDC9(m.s.)--> sAPP695alpha(h) + APP-CTFalpha(h) (cleavage) | APP695(h) + PS1(m.s.) <==> APP695(h):PS1(m.s.) (binding) | PS1(m) + APP695(h) <==> PS1(m):APP695(h) (binding) | APP(h) --> APP695(h) (expression). | Syntaxin5(h) --> APP695(h) (increase of abundance) | FE65L2(h) + APP751(h) <==> FE65L2(h):APP751(h) (binding) | X11L(h) + APP751(h) <==> X11L(h):APP751(h) (binding) | APP751(h) + APBA3(h) <==> APP751(h):APBA3(h) (binding) | APBA3(h) + APP751(h) <==> APBA3(h):APP751(h) (binding) | APP751(h) + Fe65L2-II(h) <==> APP751(h):Fe65L2-II(h) (binding) | APP751(h) + Fe65(h) <==> APP751(h):Fe65(h) (binding) | APP751(h) + 2 ATP --> APP751(h){pT654}{pS655} + 2 ADP (phosphorylation) | APP751(h) --> APP-C83(h) + protein remnants (cleavage) | APP751(h) --> Abeta40(h) (activation) | APP751(h) --adam(h)--> sAPP751alpha(h) + protein remnants (cleavage) | APP751(h) --adam(m)--> sAPP751alpha(h) + protein remnants (cleavage) | APP751(h) --> APP-C99(h) + protein remnants (cleavage) | APP751(h) --> APP751-C89(h) + protein remnants (cleavage) | APP751(h) --> AICD50(h) + protein remnants (cleavage) | APP751(h) --> Abeta42(h) (cleavage) | APP751(h) + ATP --> APP751(h){pT724} + ADP (phosphorylation) | APP751(h) --> sAPP751alpha(h) + protein remnants (cleavage) | APP751(h) --> sAPP751beta(h) + protein remnants (cleavage) | APP(h) --> APP751(h) (expression). | Fibulin 1-D(h) + APP770(h) <==> Fibulin 1-D(h):APP770(h) (binding) | APP770(h) + Fibulin 1-C(h) <==> APP770(h):Fibulin 1-C(h) (binding) | APP770(h) --TACE(h)--> sAPP770alpha(h) + APP-C83(h) (cleavage) | APP770(h) --MDC9(h)--> sAPP770alpha(h) + APP-C83(h) (cleavage) | APP770(h) --adam10(h)--> sAPP770alpha(h) + APP-C83(h) (cleavage) | APP770(h) --TACE(mo)--> APP-C83(h) + protein remnants (cleavage) | APP770(h) --adam10(mo)--> APP-C83(h) + protein remnants (cleavage) | APP770(h) --> sAPP770alpha(h) + protein remnants (cleavage) | APP770(h) --> Abeta40(h) + protein remnants (cleavage) | APP(h) --> APP770(h) (expression). | GM-CSFRalpha(h) --> APP770(h) (increase of abundance) | APP(h) --> APP(h) (expression). | hsa-miR-106a --/ APP(h) (translational repression). | hsa-miR-520c --/ APP(h) (translational repression). | APP(h) --> APP305(h) (expression). | APP(h) --> L-APP677(h) (expression). | APP(h) --> L-APP696(h) (expression). | APP(h) --> APP714(h) (expression). | APP(h) --> L-APP733(h) (expression). | APP(h) --> L-APP752(h) (expression). | APP(h) --> APP639(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 198 | Phosphoserine (by CK2). | Swiss-Prot 53.0 | 206 | Phosphoserine (by CK1). | Swiss-Prot 53.0 | 542 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 571 | N-linked (GlcNAc...) (Probable). | Swiss-Prot 53.0 | 656 | O-linked (Xyl...) (chondroitin sulfate);in L-APP isoforms. | Swiss-Prot 53.0 | 729 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 730 | Phosphoserine (by APP-kinase I) (Bysimilarity). | Swiss-Prot 53.0 | 743 | Phosphothreonine (by CDK5 and MAPK10). | Swiss-Prot 53.0 | 757 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 743 | Phosphothreonine (GSK-3beta) | 8764598 | Phospho.ELM 6.0 | 757 | Phosphotyrosine | 11279131 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr21 |
Promoter: 26464503 - 26466503 | Agilent_014791 |
chr21 |
Promoter: 26464503 - 26466503 | GoldenGate_Methylation_Cancer_Panel_I |
chr21 |
Promoter: 26464503 - 26466503 | GoldenGate_Methylation_Cancer_Panel_I |
chr21 |
Promoter: 26464503 - 26466503 | GoldenGate_Methylation_Cancer_Panel_I |
chr21 |
Promoter: 26464503 - 26466503 | GSE27584 |
chr21 |
Promoter: 26464503 - 26466503 | GSE27584 |
chr21 |
Promoter: 26464503 - 26466503 | GSE27584 |