| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3002 |
Name | GZMB |
Synonymous | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1);GZMB;granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
Definition | C11|CTLA-1|T-cell serine protease 1-3E|cathepsin G-like 1|cytotoxic T-lymphocyte proteinase 2|cytotoxic serine protease B|fragmentin 2|fragmentin-2|granzyme B|human lymphocyte protein |
Position | 14q11.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | GZMB(h) --> granzymeB(h) (expression). | proCaspase-3(h) --granzymeB(h)--> Caspase-3-p20(h) + Caspase-3-p12(h) (processing) | proCaspase-7(h) --granzymeB(h)--> Caspase-7-p12(h) + Caspase-7-p20(h) + protein remnants (processing) | proCaspase-10(h) --granzymeB(h)--> Caspase-10-p12(h) + protein remnants (processing) | Bid(m) --granzymeB(h)--> protein remnants (processing) | proCaspase-9(h) --granzymeB(h)--> Caspase-9-p35(h) + Caspase-9-p10(h) (processing) | Bid(v.s.) --granzymeB(h)--> tBid-p13(v.s.) + protein remnants (processing) | ABP-280(h) --granzymeB(h)--> ABP-280-p205(h) + protein remnants (cleavage) | ABP-280(h) --granzymeB(h)--> ABP-280-p200(h) + protein remnants (cleavage) | ABP-280(h) --granzymeB(h)--> ABP-280-p110(h) + protein remnants (cleavage) | ABP-280(h) + granzymeB(h) <==> ABP-280(h):granzymeB(h) (binding) | GZMB(h) --> granzymeB(h) (expression). | Bid(h) --granzymeB(h)--> protein remnants (cleavage) | proCaspase-3(h) --granzymeB(h)--> Caspase-3-p19(h) + Caspase-3-p17(h) (cleavage) |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 71 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 104 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for GZMB | ||