| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 29110 |
Name | TBK1 |
Synonymous | TANK-binding kinase 1;TBK1;TANK-binding kinase 1 |
Definition | NF-kB-activating kinase|NF-kappa-B-activating kinase|serine/threonine-protein kinase TBK1 |
Position | 12q14.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | TBK1(h) + IRF-3(h) <==> TBK1(h):IRF-3(h) (binding) | TRIF(h) + TBK1(h) <==> TRIF(h):TBK1(h) (binding) | TRIF(h){p} + TBK1(h) <==> TRIF(h){p}:TBK1(h) (binding) | TBK1(h) + TANK(h) + IKK-gamma(h) <==> TBK1(h):TANK(h):IKK-gamma(h) (binding) | TANK(h) + TBK1(h) <==> TANK(h):TBK1(h) (binding) | TANK(h) + TBK1(h) <==> TANK(h):TBK1(h) (binding) | TBK1(h) + ATP --> TBK1(h){p} + ADP (phosphorylation; automodification) | TBK1(h) + sike(h) <==> TBK1(h):sike(h) (binding) | TBK1(h) --> RIP(h) (increase of abundance) | TBK1(h) --> TBK1(h) (expression). | IFNalpha1(h) --> TBK1(h) (increase of abundance) | IRF-3(h) + ATP --TBK1(h)--> IRF-3(h){p} + ADP (phosphorylation) | IRF-7(h) + ATP --TBK1(h)--> IRF-7(h){p} + ADP (phosphorylation) | IkappaB-alpha(h) + NTP --TBK1(h)--> IkappaB-alpha(h){pS36} + NDP (phosphorylation) | IKK-beta(v.s.) + 2 ATP --TBK1(h)--> IKK-beta(v.s.){pS177}{pS181} + 2 ADP (phosphorylation) | IkappaB-beta(h) + ATP --TBK1(h)--> IkappaB-beta(h){pS23} + ADP (phosphorylation) | RelA-p65(m.s.) + ATP --TBK1(h)--> RelA-p65(m.s.){pS536} + ADP (phosphorylation) | IRF-3(m.s.) + ATP --TBK1(h)--> IRF-3(m.s.){p} + ADP (phosphorylation) | IRF-7(m.s.) + ATP --TBK1(h)--> IRF-7(m.s.){p} + ADP (phosphorylation) | HCV-NS3-1B(HCV1B) + TBK1(h) <==> HCV-NS3-1B(HCV1B):TBK1(h) (binding) | TBK1(h) + IRF-3(h) <==> TBK1(h):IRF-3(h) (binding) | TICAM(h) + TBK1(h) <==> TICAM(h):TBK1(h) (binding) | TBK1(h) + ATP --> TBK1(h){p} + ADP (phosphorylation; automodification) | TBK1(h) + TRIF(h) <==> TBK1(h):TRIF(h) (binding) | TBK1(h) --> IFNB1(h) (transactivation) | TBK1(h) --> TBK1(h) (expression). | HCV-NS3-1B(HCV1B) --/ TBK1(h) (inhibition) | HCV-NS3-1B(HCV1B):HCV-NS4A-1B(HCV1B) --/ TBK1(h) (inhibition) | c-Rel(m.s.) + ATP --TBK1(h)--> c-Rel(m.s.){p} + ADP (phosphorylation) | IRF-3(m.s.) + ATP --TBK1(h)--> IRF-3(m.s.){p} + ADP (phosphorylation) | IRF-7(m.s.) + ATP --TBK1(h)--> IRF-7(m.s.){p} + ADP (phosphorylation) | TANK(h) + ATP --TBK1(h)--> TANK(h){p} + ADP (phosphorylation) |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 172 | Phosphoserine (by autocatalysis). | Swiss-Prot 53.0 | 172 | Phosphoserine | 11839743 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr12 |
Promoter: 63130704 - 63132704 | Agilent_014791 |
chr12 |
Promoter: 63130704 - 63132704 | GSE27584 |
chr12 |
Promoter: 63130704 - 63132704 | Agilent_014791_44K |