| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 29110 |
Name | TBK1 |
Synonym | NAK|T2K;TANK-binding kinase 1;TBK1;TANK-binding kinase 1 |
Definition | NF-kB-activating kinase|NF-kappa-B-activating kinase|serine/threonine-protein kinase TBK1 |
Position | 12q14.1 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | RIG-I-like receptor signaling pathway;KEGG PATHWAY;hsa04622 |
Pathway | TRAM Cascade;PID Reactome;500465 |
Pathway | Cytosolic DNA-sensing pathway;KEGG PATHWAY;hsa04623 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | Toll receptor signaling pathway;PANTHER;P00054 |
Disease | Virus disease;FunDO |
Disease | Infection;FunDO |
Disease | Chronic simple glaucoma;FunDO |
External Links | |
Links to Entrez Gene | 29110 |
Links to all GeneRIF Items | 29110 |
Links to iHOP | 29110 |
Sequence Information | |
Nucleotide Sequence | >29110 : length: 3160 AAGTGAGACGGCCGCGGGCTGAGGGGCCAAGGCGGCGCGGGGCGCGGTCGGTCAGGCCTG CGCCGCCCGGCGGGGAGCGCTCCCGCCCCCTGTGGGAGGCTGGGATGCTGAGTCAGAGCG GGGGCGGGGGCGGGCGCACCGAGAAGCCCCGGACGACCCGAGGCCAAGCCATCCAGGACC CCGGCTGCGTGGACACTGCCTCTGGGTATAACAAGAGGATTGCCTGATCCAGCCAAGATG CAGAGCACTTCTAATCATCTGTGGCTTTTATCTGATATTTTAGGCCAAGGAGCTACTGCA AATGTCTTTCGTGGAAGACATAAGAAAACTGGTGATTTATTTGCTATCAAAGTATTTAAT AACATAAGCTTCCTTCGTCCAGTGGATGTTCAAATGAGAGAATTTGAAGTGTTGAAAAAA CTCAATCACAAAAATATTGTCAAATTATTTGCTATTGAAGAGGAGACAACAACAAGACAT AAAGTACTTATTATGGAATTTTGTCCATGTGGGAGTTTATACACTGTTTTAGAAGAACCT TCTAATGCCTATGGACTACCAGAATCTGAATTCTTAATTGTTTTGCGAGATGTGGTGGGT GGAATGAATCATCTACGAGAGAATGGTATAGTGCACCGTGATATCAAGCCAGGAAATATC ATGCGTGTTATAGGGGAAGATGGACAGTCTGTGTACAAACTCACAGATTTTGGTGCAGCT AGAGAATTAGAAGATGATGAGCAGTTTGTTTCTCTGTATGGCACAGAAGAATATTTGCAC CCTGATATGTATGAGAGAGCAGTGCTAAGAAAAGATCATCAGAAGAAATATGGAGCAACA GTTGATCTTTGGAGCATTGGGGTAACATTTTACCATGCAGCTACTGGATCACTGCCATTT AGACCCTTTGAAGGGCCTCGTAGGAATAAAGAAGTGATGTATAAAATAATTACAGGAAAG CCTTCTGGTGCAATATCTGGAGTACAGAAAGCAGAAAATGGACCAATTGACTGGAGTGGA GACATGCCTGTTTCTTGCAGTCTTTCTCGGGGTCTTCAGGTTCTACTTACCCCTGTTCTT GCAAACATCCTTGAAGCAGATCAGGAAAAGTGTTGGGGTTTTGACCAGTTTTTTGCAGAA ACTAGTGATATACTTCACCGAATGGTAATTCATGTTTTTTCGCTACAACAAATGACAGCT CATAAGATTTATATTCATAGCTATAATACTGCTACTATATTTCATGAACTGGTATATAAA CAAACCAAAATTATTTCTTCAAATCAAGAACTTATCTACGAAGGGCGACGCTTAGTCTTA GAACCTGGAAGGCTGGCACAACATTTCCCTAAAACTACTGAGGAAAACCCTATATTTGTA GTAAGCCGGGAACCTCTGAATACCATAGGATTAATATATGAAAAAATTTCCCTCCCTAAA GTACATCCACGTTATGATTTAGACGGGGATGCTAGCATGGCTAAGGCAATAACAGGGGTT GTGTGTTATGCCTGCAGAATTGCCAGTACCTTACTGCTTTATCAGGAATTAATGCGAAAG GGGATACGATGGCTGATTGAATTAATTAAAGATGATTACAATGAAACTGTTCACAAAAAG ACAGAAGTTGTGATCACATTGGATTTCTGTATCAGAAACATTGAAAAAACTGTGAAAGTA TATGAAAAGTTGATGAAGATCAACCTGGAAGCGGCAGAGTTAGGTGAAATTTCAGACATA CACACCAAATTGTTGAGACTTTCCAGTTCTCAGGGAACAATAGAAACCAGTCTTCAGGAT ATCGACAGCAGATTATCTCCAGGTGGATCACTGGCAGACGCATGGGCACATCAAGAAGGC ACTCATCCGAAAGACAGAAATGTAGAAAAACTACAAGTCCTGTTAAATTGCATGACAGAG ATTTACTATCAGTTCAAAAAAGACAAAGCAGAACGTAGATTAGCTTATAATGAAGAACAA ATCCACAAATTTGATAAGCAAAAACTGTATTACCATGCCACAAAAGCTATGACGCACTTT ACAGATGAATGTGTTAAAAAGTATGAGGCATTTTTGAATAAGTCAGAAGAATGGATAAGA AAGATGCTTCATCTTAGGAAACAGTTATTATCGCTGACTAATCAGTGTTTTGATATTGAA GAAGAAGTATCAAAATATCAAGAATATACTAATGAGTTACAAGAAACTCTGCCTCAGAAA ATGTTTACAGCTTCCAGTGGAATCAAACATACCATGACCCCAATTTATCCAAGTTCTAAC ACATTAGTAGAAATGACTCTTGGTATGAAGAAATTAAAGGAAGAGATGGAAGGGGTGGTT AAAGAACTTGCTGAAAATAACCACATTTTAGAAAGGTTTGGCTCTTTAACCATGGATGGT GGCCTTCGCAACGTTGACTGTCTTTAGCTTTCTAATAGAAGTTTAAGAAAAGTTTCCGTT TGCACAAGAAAATAACGCTTGGGCATTAAATGAATGCCTTTATAGATAGTCACTTGTTTC TACAATTCAGTATTTGATGTGGTCGTGTAAATATGTACAATATTGTAAATACATAAAAAA TATACAAATTTTTGGCTGCTGTGAAGATGTAATTTTATCTTTTAACATTTATAATTATAT GAGGAAATTTGACCTCAGTGATCACGAGAAGAAAGCCATGACCGACCAATATGTTGACAT ACTGATCCTCTACTCTGAGTGGGGCTAAATAAGTTATTTTCTCTGACCGCCTACTGGAAA TATTTTTAAGTGGAACCAAAATAGGCATCCTTACAAATCAGGAAGACTGACTTGACACGT TTGTAAATGGTAGAACGGTGGCTACTGTGAGTGGGGAGCAGAACCGCACCACTGTTATAC TGGGATAACAATTTTTTTGAGAAGGATAAAGTGGCATTATTTTATTTTACAAGGTGCCCA GATCCCAGTTATCCTTGTATCCATGTAATTTCAGATGAATTATTAAGCAAACATTTTAAA GTGAATTCATTATTAAAAACTATTCATTTTTTTCCTTTGGCCATAAATGTGTAATTGTCA TTAAAATTCTAAGGTCATTTCAACTGTTTTAAGCTGTATATTTCTTTAATTCTGCTTACT ATTTCATGGAAAAAAATAAATTTCTCAATTTTAATGTAAA |
Protein Sequence | >29110 : length: 729 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK VYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQE GTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQ KMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD GGLRNVDCL |