| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2534 |
Name | FYN |
Synonymous | FYN proto-oncogene, Src family tyrosine kinase;FYN;FYN proto-oncogene, Src family tyrosine kinase |
Definition | FYN oncogene related to SRC, FGR, YES|OKT3-induced calcium influx regulator|c-syn protooncogene|proto-oncogene Syn|proto-oncogene c-Fyn|src-like kinase|src/yes-related novel|tyrosine kinase p59fyn(T)|tyrosine-protein kinase Fyn |
Position | 6q21 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Fyn(h) + 3BP2(m) <==> Fyn(h):3BP2(m) (binding) | Vav(h) + Fyn(h) <==> Vav(h):Fyn(h) (binding) | GP4(h) + Fyn(h) <==> GP4(h):Fyn(h) (binding) | Fyn(h) --> p38(h){p} (increase of phosphorylation) | APS(m){p} + Fyn(h) <==> APS(m){p}:Fyn(h) (binding) | c-Kit(h){pY} + Fyn(h) <==> c-Kit(h){pY}:Fyn(h) (binding) | Fyn(h) + Raf-1(h){p} <==> Fyn(h):Raf-1(h){p} (binding) | c-Cbl(h){pY} + Fyn(h) <==> c-Cbl(h){pY}:Fyn(h) (binding) | Fyn(h) + Pyk2-isoform1(h){p} <==> Fyn(h):Pyk2-isoform1(h){p} (binding) | beta3-integrin(v.s.) + Fyn(h) <==> beta3-integrin(v.s.):Fyn(h) (binding) | alpha IIb-integrin(h):beta3-integrin(h) + Fyn(h) <==> alpha IIb-integrin(h):beta3-integrin(h):Fyn(h) (binding) | Fyn(h) + uPAR(h) <==> Fyn(h):uPAR(h) (binding) | Fyn(h) + LIME(h){pY} <==> Fyn(h):LIME(h){pY} (binding) | Fyn(h) + SKAP55(h){pY} <==> Fyn(h):SKAP55(h){pY} (binding) | Fyn(h) + CIN85(m.s.) <==> Fyn(h):CIN85(m.s.) (binding) | SLP-76(h) + Fyn(h) <==> SLP-76(h):Fyn(h) (binding) | Fyn(h) + ATP --> Fyn(h){pY} + ADP (phosphorylation) | c-Cbl(h) + Fyn(h) <==> c-Cbl(h):Fyn(h) (binding) | Fyn(h) + Mayven(m.s.) <==> Fyn(h):Mayven(m.s.) (binding) | Fyn(h) + ATP --> Fyn(h){p} + ADP (phosphorylation; automodification) | Fyn(h) + Map-2c(h) <==> Fyn(h):Map-2c(h) (binding) | Fyn(h) + RPTPzeta-L(h) <==> Fyn(h):RPTPzeta-L(h) (binding) | Fyn(h) + ATP --> Fyn(h){pY417} + ADP (phosphorylation) | Fyn(h) + Tyk2(h){pY} <==> Fyn(h):Tyk2(h){pY} (binding) | Fyn(h) + Jak2(h){pY} <==> Fyn(h):Jak2(h){pY} (binding) | Fyn(h) + Tau(h) <==> Fyn(h):Tau(h) (binding) | Fyn(h) + Cas(r) <==> Fyn(h):Cas(r) (binding) | Fyn(h) + Cas(h) <==> Fyn(h):Cas(h) (binding) | HEF1(h) + Fyn(h) <==> HEF1(h):Fyn(h) (binding) | Fyn(h) + HCV-NS5A-1A-H77(HCV1AH77) <==> Fyn(h):HCV-NS5A-1A-H77(HCV1AH77) (binding) | WASP(h) + Fyn(h) <==> WASP(h):Fyn(h) (binding) | NR2B(h) + Fyn(h) + mib2(r) <==> NR2B(h):Fyn(h):mib2(r) (binding) | Lyn(h) + CD11B(h):beta2-integrin(h) + LFA-1(h) + Fgr(h) + Hck(h) + Fyn(h) <==> CD11B(h):beta2-integrin(h):uPAR(h):Lyn(h):Fyn(h):Hck(h):Fgr(h):LFA-1(h) (binding) | ErbB4(h) + Fyn(h) <==> ErbB4(h):Fyn(h) (binding) | Caspr(r) + Fyn(h) <==> Caspr(r):Fyn(h) (binding) | Fyn(h) + SH2D1A(h) <==> Fyn(h):SH2D1A(h) (binding) | Fyn(h) + CD244(h){pY} <==> Fyn(h):CD244(h){pY} (binding) | EAT-2(h){pY128} + Fyn(h) <==> EAT-2(h){pY128}:Fyn(h) (binding) | Fyn(h) + EAT-2(h){p} <==> Fyn(h):EAT-2(h){p} (binding) | Fyn(h) + CD244(m.s.){pY} <==> Fyn(h):CD244(m.s.){pY} (binding) | Fyn(h) --> SH2D1A(h):CD229(h) (increase of binding) | Fyn(h) --> EAT-2(m):SLAM(h) (increase of binding) | Fyn(h) --> Cd244(m):EAT-2(m) (increase of binding) | Fyn(h) --> CD229(h):EAT-2(m) (increase of binding) | Fyn(h) --> CD84(h):EAT-2(m) (increase of binding) | Fyn(h) + ATP --> Fyn(h){pT12} + ADP (phosphorylation) | SLAP-130(h) + Fyn(h) <==> SLAP-130(h):Fyn(h) (binding) | Fyn(h) + Pyk2(m.s.) <==> Fyn(h):Pyk2(m.s.) (binding) | Lck(h) + Fyn(h) + RasGAP(h){pY460} <==> Lck(h):Fyn(h):RasGAP(h){pY460} (binding) | FYN(h) --> Fyn(h) (expression). | Fyn(h){pY} --RPTPzeta-L(h)--> Fyn(h) + p (dephosphorylation) | APS(m) + NTP --Fyn(h)--> APS(m){p} + NDP (phosphorylation) | p62Dok-1(h) + ATP --Fyn(h)--> p62Dok-1(h){pY} + ADP (phosphorylation) | beta-catenin(m) + ATP --Fyn(h)--> beta-catenin(m){pY142} + ADP (phosphorylation) | plakoglobin(h) + ATP --Fyn(h)--> plakoglobin(h){pY133}{pY549} + ADP (phosphorylation) | Prap(h) + ATP --Fyn(h)--> Prap(h){pY} + ADP (phosphorylation) | Map-2c(h) + ATP --Fyn(h)--> Map-2c(h){pY67} + ADP (phosphorylation) | Map-2c(h) + ATP --Fyn(h)--> Map-2c(h){pY} + ADP (phosphorylation) | Enolase(m.s.) + ATP --Fyn(h)--> Enolase(m.s.){p} + ADP (phosphorylation) | WASP(h) + ATP --Fyn(h)--> WASP(h){pY291} + ADP (phosphorylation) | NR2A(r) + ATP --Fyn(h)--> NR2A(r){pY} + ADP (phosphorylation) | NR2B(r) + ATP --Fyn(h)--> NR2B(r){pY} + ADP (phosphorylation) | NR2B(m.s.) + 7 ATP --Fyn(h)--> NR2B(m.s.){pY932}{pY1039}{pY1070}{pY1109}{pY1252}{pY1336}{pY1472} + 7 ADP (phosphorylation) | NR2B(m.s.) + ATP --Fyn(h)--> NR2B(m.s.){pY} + ADP (phosphorylation) | PLCgamma2(h) + ATP --Fyn(h)--> PLCgamma2(h){pY753}{pY759} + ADP (phosphorylation) | histone H3(m.s.) + ATP --Fyn(h)--> histone H3(m.s.){pS11} + ADP (phosphorylation) | Src(m.s.) + ATP --Fyn(h)--> Src(m.s.){p} + ADP (phosphorylation) | PDE4D4(r) + Fyn-isoform1(h) <==> PDE4D4(r):Fyn-isoform1(h) (binding) | PDE4D4(h) + Fyn-isoform1(h) <==> PDE4D4(h):Fyn-isoform1(h) (binding) | c-Cbl(h){pY} + Fyn-isoform1(h) <==> c-Cbl(h){pY}:Fyn-isoform1(h) (binding) | Fyn-isoform1(h) + c-Cbl(h) <==> Fyn-isoform1(h):c-Cbl(h) (binding) | ErbB4(h) + Fyn-isoform1(h) <==> ErbB4(h):Fyn-isoform1(h) (binding) | Fyn-isoform1(h) + 2 ATP --> Fyn-isoform1(h){pY420}{pY531} + 2 ADP (phosphorylation) | FYN(h) --> Fyn-isoform1(h) (expression). | Fyn-isoform2(h) + SH2D1A(h) <==> Fyn-isoform2(h):SH2D1A(h) (binding) | FYN(h) --> Fyn-isoform2(h) (expression). | SLAM(h) + ATP --Fyn-isoform2(h)--> SLAM(h){pY} + ADP (phosphorylation) |
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Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 2 | N-myristoyl glycine. | Swiss-Prot 53.0 | 3 | S-palmitoyl cysteine (By similarity). | Swiss-Prot 53.0 | 6 | S-palmitoyl cysteine (By similarity). | Swiss-Prot 53.0 | 12 | Phosphothreonine (by PKC) (Bysimilarity). | Swiss-Prot 53.0 | 21 | Phosphoserine. | Swiss-Prot 53.0 | 420 | Phosphotyrosine; by autocatalysis. | Swiss-Prot 53.0 | 531 | Phosphotyrosine; negative regulation. | Swiss-Prot 53.0 | 530 | Phosphotyrosine (Csk) | 1985196 | Phospho.ELM 6.0 | 419 | Phosphotyrosine (Fes;Fyn) | 1985196 | Phospho.ELM 6.0 | 27 | Phosphotyrosine (Fyn;PDGFR be) | 9425276 | Phospho.ELM 6.0 | 29 | Phosphotyrosine (Fyn) | 9425276 | Phospho.ELM 6.0 | 38 | Phosphotyrosine (Fyn) | 9425276 | Phospho.ELM 6.0 | 11 | Phosphothreonine | 15537652 | Phospho.ELM 6.0 | 213 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr6 |
Promoter: 112300820 - 112302820 | Agilent_014791 |
chr6 |
Promoter: 112300820 - 112302820 | GoldenGate_Methylation_Cancer_Panel_I |
chr6 |
Promoter: 112300820 - 112302820 | GSE27584 |
chr6 |
Promoter: 112300820 - 112302820 | Agilent_014791_44K |
chr6 |
Promoter: 112300820 - 112302820 | PMID:16367923 |
chr6 |
Promoter: 112147458 - 112149458 | PMID:16367923 |
chr6 |
Promoter: 112186478 - 112188478 | PMID:16367923 |