| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2534 |
Name | FYN |
Synonym | SLK|SYN|p59-FYN;FYN proto-oncogene, Src family tyrosine kinase;FYN;FYN proto-oncogene, Src family tyrosine kinase |
Definition | FYN oncogene related to SRC, FGR, YES|OKT3-induced calcium influx regulator|c-syn protooncogene|proto-oncogene Syn|proto-oncogene c-Fyn|src-like kinase|src/yes-related novel|tyrosine kinase p59fyn(T)|tyrosine-protein kinase Fyn |
Position | 6q21 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Collagen adhesion via GPVI;PID Reactome;500288 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Nephrin/Neph1 signaling in the kidney podocyte;PID Curated;200132 |
Pathway | Regulation of p38-alpha and p38-beta;PID Curated;200054 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Ephrin B reverse signaling;PID Curated;200173 |
Pathway | HIV Infection;Reactome;REACT:6185 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | Alpha-synuclein signaling;PID Curated;200187 |
Pathway | CXCR4-mediated signaling events;PID Curated;200083 |
Pathway | role of mef2d in t-cell apoptosis;PID BioCarta;100109 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | bioactive peptide induced signaling pathway;PID BioCarta;100226 |
Pathway | E-cadherin signaling in keratinocytes;PID Curated;200125 |
Pathway | Class I PI3K signaling events;PID Curated;200098 |
Pathway | Nef and signal transduction;PID Reactome;500755 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Syndecan-3-mediated signaling events;PID Curated;200170 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Reelin signaling pathway;PID Curated;200051 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | CD28 dependent Vav1 pathway;PID Reactome;500486 |
Pathway | Glypican 1 network;PID Curated;200021 |
Pathway | Interactions of the immunoglobulin superfamily (IgSF) member proteins;Reactome;REACT:23853 |
Pathway | Pathogenic Escherichia coli infection;KEGG PATHWAY;hsa05130 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | tsp-1 induced apoptosis in microvascular endothelial cell;PID BioCarta;100010 |
Pathway | Parkinson disease;PANTHER;P00049 |
Pathway | Axon guidance mediated by semaphorins;PANTHER;P00007 |
Pathway | Cell surface interactions at the vascular wall;PID Reactome;500305 |
Pathway | Cadherin signaling pathway;PANTHER;P00012 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;PID Reactome;500075 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | t cell receptor signaling pathway;PID BioCarta;100022 |
Pathway | EPHA forward signaling;PID Curated;200121 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | NCAM signaling for neurite out-growth;PID Reactome;500079 |
Pathway | Prion diseases;KEGG PATHWAY;hsa05020 |
Pathway | Viral myocarditis;KEGG PATHWAY;hsa05416 |
Pathway | Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066 |
Pathway | Ephrin A reverse signaling;PID Curated;200048 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | integrin signaling pathway;PID BioCarta;100123 |
Pathway | il-7 signal transduction;PID BioCarta;100125 |
Pathway | lck and fyn tyrosine kinases in initiation of tcr activation;PID BioCarta;100023 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | ErbB4 signaling events;PID Curated;200009 |
Pathway | amb2 Integrin signaling;PID Curated;200108 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | Netrin-mediated signaling;PID Curated;200074 |
Disease | CHEMDEPENDENCY;GAD |
Disease | Alzheimer's disease;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | blood pressure, arterial hypertension;GAD |
Disease | alcoholism;GAD |
Disease | NEUROLOGICAL;GAD |
External Links | |
Links to Entrez Gene | 2534 |
Links to all GeneRIF Items | 2534 |
Links to iHOP | 2534 |
Sequence Information | |
Nucleotide Sequence | >2534 : length: 3767 AGTAGCAGCGAGCAGCCGCGCTGGTGGCGGCGGCGCGTCGTTGCAGTTGCGCCATCTGTC AGGAGCGGAGCCGGCGAGGAGGGGGCTGCCGCGGGCGAGGAGGAGGGGTCGCCGCGAGCC GAAGGCCTTCGAGACCCGCCCGCCGCCCGGCGGCGAGAGTAGAGGCGAGGTTGTTGTGCG AGCGGCGCGTCCTCTCCCGCCCGGGCGCGCCGCGCTTCTCCCAGCGCACCGAGGACCGCC CGGGCGCACACAAAGCCGCCGCCCGCGCCGCACCGCCCGGCGGCCGCCGCCCGCGCCAGG GAGGGATTCGGCCGCCGGGCCGGGGACACCCCGGCGCCGCCCCCTCGGTGCTCTCGGAAG GCCCACCGGCTCCCGGGCCCGCCGGGGACCCCCCGGAGCCGCCTCGGCCGCGCCGGAGGA GGGCGGGGAGAGGACCATGTGAGTGGGCTCCGGAGCCTCAGCGCCGCGCAGTTTTTTTGA AGAAGCAGGATGCTGATCTAAACGTGGAAAAAGACCAGTCCTGCCTCTGTTGTAGAAGAC ATGTGGTGTATATAAAGTTTGTGATCGTTGGCGGACATTTTGGAATTTAGATAATGGGCT GTGTGCAATGTAAGGATAAAGAAGCAACAAAACTGACGGAGGAGAGGGACGGCAGCCTGA ACCAGAGCTCTGGGTACCGCTATGGCACAGACCCCACCCCTCAGCACTACCCCAGCTTCG GTGTGACCTCCATCCCCAACTACAACAACTTCCACGCAGCCGGGGGCCAAGGACTCACCG TCTTTGGAGGTGTGAACTCTTCGTCTCATACGGGGACCTTGCGTACGAGAGGAGGAACAG GAGTGACACTCTTTGTGGCCCTTTATGACTATGAAGCACGGACAGAAGATGACCTGAGTT TTCACAAAGGAGAAAAATTTCAAATATTGAACAGCTCGGAAGGAGATTGGTGGGAAGCCC GCTCCTTGACAACTGGAGAGACAGGTTACATTCCCAGCAATTATGTGGCTCCAGTTGACT CTATCCAGGCAGAAGAGTGGTACTTTGGAAAACTTGGCCGAAAAGATGCTGAGCGACAGC TATTGTCCTTTGGAAACCCAAGAGGTACCTTTCTTATCCGCGAGAGTGAAACCACCAAAG GTGCCTATTCACTTTCTATCCGTGATTGGGATGATATGAAAGGAGACCATGTCAAACATT ATAAAATTCGCAAACTTGACAATGGTGGATACTACATTACCACCCGGGCCCAGTTTGAAA CACTTCAGCAGCTTGTACAACATTACTCAGAGAGAGCTGCAGGTCTCTGCTGCCGCCTAG TAGTTCCCTGTCACAAAGGGATGCCAAGGCTTACCGATCTGTCTGTCAAAACCAAAGATG TCTGGGAAATCCCTCGAGAATCCCTGCAGTTGATCAAGAGACTGGGAAATGGGCAGTTTG GGGAAGTATGGATGGAGAAAGCTGATGGTTTGTGTTTTAACTTAACTGTGATTGCATCGA GTTGTACCCCACAAACTTCTGGATTGGCTAAAGATGCTTGGGAAGTTGCACGTCGTTCGT TGTGTCTGGAGAAGAAGCTGGGTCAGGGGTGTTTCGCTGAAGTGTGGCTTGGTACCTGGA ATGGAAACACAAAAGTAGCCATAAAGACTCTTAAACCAGGCACAATGTCCCCCGAATCAT TCCTTGAGGAAGCGCAGATCATGAAGAAGCTGAAGCACGACAAGCTGGTCCAGCTCTATG CAGTGGTGTCTGAGGAGCCCATCTACATCGTCACCGAGTATATGAACAAAGGAAGTTTAC TGGATTTCTTAAAAGATGGAGAAGGAAGAGCTCTGAAATTACCAAATCTTGTGGACATGG CAGCACAGGTGGCTGCAGGAATGGCTTACATCGAGCGCATGAATTATATCCATAGAGATC TGCGATCAGCAAACATTCTAGTGGGGAATGGACTCATATGCAAGATTGCTGACTTCGGAT TGGCCCGATTGATAGAAGACAATGAGTACACAGCAAGACAAGGTGCAAAGTTCCCCATCA AGTGGACGGCCCCCGAGGCAGCCCTGTACGGGAGGTTCACAATCAAGTCTGACGTGTGGT CTTTTGGAATCTTACTCACAGAGCTGGTCACCAAAGGAAGAGTGCCATACCCAGGCATGA ACAACCGGGAGGTGCTGGAGCAGGTGGAGCGAGGCTACAGGATGCCCTGCCCGCAGGACT GCCCCATCTCTCTGCATGAGCTCATGATCCACTGCTGGAAAAAGGACCCTGAAGAACGCC CCACTTTTGAGTACTTGCAGAGCTTCCTGGAAGACTACTTTACCGCGACAGAGCCCCAGT ACCAACCTGGTGAAAACCTGTAAGGCCCGGGTCTGCGGAGAGAGGCCTTGTCCCAGAGGC TGCCCCACCCCTCCCCATTAGCTTTCAATTCCGTAGCCAGCTGCTCCCCAGCAGCGGAAC CGCCCAGGATCAGATTGCATGTGACTCTGAAGCTGACGAACTTCCATGGCCCTCATTAAT GACACTTGTCCCCAAATCCGAACCTCCTCTGTGAAGCATTCGAGACAGAACCTTGTTATT TCTCAGACTTTGGAAAATGCATTGTATCGATGTTATGTAAAAGGCCAAACCTCTGTTCAG TGTAAATAGTTACTCCAGTGCCAACAATCCTAGTGCTTTCCTTTTTTAAAAATGCAAATC CTATGTGATTTTAACTCTGTCTTCACCTGATTCAACTAAAAAAAAAAAAGTATTATTTTC CAAAAGTGGCCTCTTTGTCTAAAACAATAAAATTTTTTTTCATGTTTTAACAAAAACCAA TCAGGACAGGTGTTTGTTTTTGTTTTCTTTTTTATAAATATGAATATATATAATATATAT GTCCCTGTACATATACAATGTGGGTGCTAATGTGGAGACTGTGGCCGGCCTGAGCCACCA AGCTGCGGGACCCAGAGGGAGGATTTTACTGCAAGTCAGCATCAAAGCACCGGTGTTATT CTGAAAACACCAGTGGCCTCATTTTTGGCTTTTGCAAAGCATGAATTTTTTCATTTGGAT TGCACTTTCCTGGTTCATGACTGTACCTGTAGGTGGTTGTTACTTTGACTCTTTTCAGGA ACCACCCCCCAAGCTGAATTTACAAGTTCTGTTAGCACTATTTGCTTCAACTTACTGCGA TTTGTTCTCAAAACTTAAAAATAAGCAAGCAAATGGCTGATACTACCAAGAGAACTGGAA GATGGATACCACACAAACTTCTTGTATAAAAATATGAATGCTGAAATGTTTCAGACATTT TTAATTTAATAAACCTGTAACCACATTTAAGTGATCTAAAACCCATAGCATTGTAGTCAT GGCAACCCGCTAAACTTTCTCATGCAACTAAAATTTCTGGGGGAAATGAGGGTGGGGGTT GTACATTTCCCATTGTAAAATAAGTGTTTTAAATGTCCTGTACTGCTAACGAATGACTTT CTATATGTCCAGGAGTTCTCCAGTGGAATAACTATGCACTACTTTACATTTCATGGGGAT GCACAAAAACAAAAAAGTATTACATTTTTAGTTGCTGTTTGTACCAACCTTAAATTACAT ATGTTTAACAACAACAAATCAAAAATCCTATTTCTATTGAGTTTTTAATACTGACTAGCA ACTCTGAAGTCTTAATTCCTTTTTTGTTATGATTTATTTGTGAGTTTACATTTTTAAATT GTTTAACTTTCTTAATTTAGTAATTAAAAAGAGAGCATTTTACATTT |
Protein Sequence | >2534 : length: 589 MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMEKADGLCFNLTVI ASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSP ESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLV DMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKF PIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCP QDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL |