Entrez Gene

Basic Information
Gene ID	2212
Name	FCGR2A
Synonymous	Fc fragment of IgG, low affinity IIa, receptor (CD32);FCGR2A;Fc fragment of IgG, low affinity IIa, receptor (CD32)
Definition	Immunoglobulin G Fc receptor II\|fc-gamma RII-a\|fc-gamma-RIIa\|fcRII-a\|igG Fc receptor II-a\|low affinity immunoglobulin gamma Fc region receptor II-a
Position	1q23
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
FcgammaRIIA(h) --> LAT(h){p} (increase of phosphorylation)
LAT(h) + FcgammaRIIA(h) <==> LAT(h):FcgammaRIIA(h) (binding)
FcgammaRIIA(h) + ATP --> FcgammaRIIA(h){pY} + ADP (phosphorylation)
FcgammaRIIA(h) --> Syk(h){pY} (increase of phosphorylation)
FcgammaRIIA(h) + n ubiquitin(h) --> FcgammaRIIA(h){ub}n (ubiquitination)
FcgammaRIIA(h) --> protein remnants (degradation)
FcgammaRIIA(h) + ubiquitin(h) --c-Cbl(h)--> FcgammaRIIA(h){ub} (ubiquitination)
FCGR2A(h) --> FcgammaRIIA(h) (expression).
FcgammaRIIA(h) + CRP(h) <==> FcgammaRIIA(h):CRP(h) (binding)
SAP(m.s.) + FcgammaRIIA(h) <==> SAP(m.s.):FcgammaRIIA(h) (binding)
FcgammaRIIA(h) + IgG1(h) <==> FcgammaRIIA(h):IgG1(h) (binding)
FcgammaRIIA(h) --> IL-6(h) (decrease of secretion)
FcgammaRIIA(h) --> IL-13(h) (decrease of secretion)
FcgammaRIIA(h) --> TNF-alpha(h) (decrease of secretion)
FcgammaRIIA(h) --> MCP-1(h) (decrease of secretion)
FCGR2A(h) --> FcgammaRIIA(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
97	N-linked (GlcNAc...).		Swiss-Prot 53.0
178	N-linked (GlcNAc...).		Swiss-Prot 53.0
281	Phosphotyrosine (Fyn;Lyn;Syk;)	8756631	Phospho.ELM 6.0
288	Phosphotyrosine (Fyn;Lyn;Syk;)	8756631	Phospho.ELM 6.0
304	Phosphotyrosine (Fyn;Lyn;Syk;)	8756631	Phospho.ELM 6.0

Transcription Factors [Top]