Entrez Gene

Basic Information
Gene ID	2212
Name	FCGR2A
Synonymous	Fc fragment of IgG, low affinity IIa, receptor (CD32);FCGR2A;Fc fragment of IgG, low affinity IIa, receptor (CD32)
Definition	Immunoglobulin G Fc receptor II\|fc-gamma RII-a\|fc-gamma-RIIa\|fcRII-a\|igG Fc receptor II-a\|low affinity immunoglobulin gamma Fc region receptor II-a
Position	1q23
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.899A>T; p.K300I; 1:161518096-161518096	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.501G>A; p.L167L; 1:161509959-161509959	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.573C>A; p.G191G; 1:161510031-161510031	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.876C>T; p.P292P; 1:161518073-161518073	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.876C>T; p.P292P; 1:161518073-161518073	thyroid	other; neoplasm	Substitution - coding silent
c.876C>T; p.P292P; 1:161518073-161518073	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.579G>A; p.T193T; 1:161510037-161510037	oesophagus	carcinoma	Substitution - coding silent
c.579G>A; p.T193T; 1:161510037-161510037	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.250C>T; p.H84Y; 1:161506480-161506480	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.672G>A; p.A224A; 1:161510889-161510889	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.482C>T; p.S161F; 1:161509940-161509940	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.8T>C; p.M3T; 1:161505475-161505475	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.38C>T; p.P13L; 1:161505505-161505505	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.721A>G; p.R241G; 1:161510938-161510938	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193C>T; p.R65C; 1:161506423-161506423	skin	malignant_melanoma	Substitution - Missense
c.193C>T; p.R65C; 1:161506423-161506423	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.547G>T; p.D183Y; 1:161510005-161510005	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.475G>A; p.G159R; 1:161509933-161509933	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.827C>T; p.T276I; 1:161518024-161518024	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.497A>G; p.H166R; 1:161509955-161509955	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.497A>G; p.H166R; 1:161509955-161509955	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.860A>T; p.Y287F; 1:161518057-161518057	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.531C>G; p.N177K; 1:161509989-161509989	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.168T>G; p.S56S; 1:161506398-161506398	stomach	adenocarcinoma	Substitution - coding silent
c.928G>C; p.D310H; 1:161518125-161518125	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.856G>A; p.G286S; 1:161518053-161518053	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.805_808delAGAA; p.K270fs*18; 1:161518002-161518005	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.842A>C; p.E281A; 1:161518039-161518039	breast	carcinoma	Substitution - Missense
c.578C>T; p.T193M; 1:161510036-161510036	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.545G>T; p.G182V; 1:161510003-161510003	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.39C>T; p.P13P; 1:161505506-161505506	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.837C>A; p.D279E; 1:161518034-161518034	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.884C>A; p.P295H; 1:161518081-161518081	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.777+1G>A; p.?; 1:161513933-161513933	stomach	carcinoma; diffuse_adenocarcinoma	Unknown
c.777+1G>A; p.?; 1:161513933-161513933	liver	carcinoma	Unknown
c.777+1G>A; p.?; 1:161513933-161513933	stomach	carcinoma; diffuse_adenocarcinoma	Unknown
c.334G>A; p.D112N; 1:161506564-161506564	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.725A>C; p.K242T; 1:161510942-161510942	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.140C>T; p.P47L; 1:161506370-161506370	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.927C>T; p.N309N; 1:161518124-161518124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.927C>T; p.N309N; 1:161518124-161518124	thyroid	other; neoplasm	Substitution - coding silent
c.67A>C; p.T23P; 1:161505534-161505534	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.67A>C; p.T23P; 1:161505534-161505534	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.138C>T; p.P46P; 1:161506368-161506368	skin	malignant_melanoma	Substitution - coding silent
c.560C>A; p.T187K; 1:161510018-161510018	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.788G>T; p.R263L; 1:161517985-161517985	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.27G>A; p.Q9Q; 1:161505494-161505494	breast	carcinoma	Substitution - coding silent
c.629G>T; p.G210V; 1:161510846-161510846	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.208G>A; p.D70N; 1:161506438-161506438	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.844A>G; p.T282A; 1:161518041-161518041	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.492C>A; p.F164L; 1:161509950-161509950	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.327C>T; p.S109S; 1:161506557-161506557	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.207C>T; p.S69S; 1:161506437-161506437	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.403G>A; p.G135R; 1:161509861-161509861	skin	malignant_melanoma	Substitution - Missense
c.194G>A; p.R65H; 1:161506424-161506424	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.6T>C; p.T2T; 1:161505473-161505473	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.217C>T; p.Q73*; 1:161506447-161506447	skin	malignant_melanoma	Substitution - Nonsense
c.777+5G>T; p.?; 1:161513937-161513937	liver	carcinoma	Unknown
c.777+5G>T; p.?; 1:161513937-161513937	liver	carcinoma	Unknown
c.578C>A; p.T193K; 1:161510036-161510036	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.802A>C; p.I268L; 1:161517999-161517999	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.384T>C; p.P128P; 1:161509842-161509842	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.730C>T; p.R244W; 1:161510947-161510947	liver	carcinoma	Substitution - Missense
c.730C>T; p.R244W; 1:161510947-161510947	liver	carcinoma	Substitution - Missense
c.658G>A; p.A220T; 1:161510875-161510875	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.365G>A; p.W122*; 1:161509823-161509823	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.882A>T; p.A294A; 1:161518079-161518079	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.167C>G; p.S56C; 1:161506397-161506397	breast	carcinoma	Substitution - Missense
c.501G>C; p.L167F; 1:161509959-161509959	skin	malignant_melanoma	Substitution - Missense
c.919C>T; p.P307S; 1:161518116-161518116	skin	malignant_melanoma	Substitution - Missense
c.723G>A; p.R241R; 1:161510940-161510940	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.570A>G; p.I190M; 1:161510028-161510028	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.757G>A; p.V253M; 1:161513912-161513912	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.699T>A; p.A233A; 1:161510916-161510916	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.91G>A; p.A31T; 1:161505992-161505992	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.91G>A; p.A31T; 1:161505992-161505992	pancreas	carcinoma	Substitution - Missense
c.892G>A; p.D298N; 1:161518089-161518089	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.812G>C; p.R271T; 1:161518009-161518009	urinary_tract; bladder	carcinoma	Substitution - Missense
c.892G>A; p.D298N; 1:161518089-161518089	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.126G>A; p.L42L; 1:161506356-161506356	skin	malignant_melanoma	Substitution - coding silent

COSMIC somatic mutation [Top]