Entrez Gene

Basic Information
Gene ID	2011
Name	MARK2
Synonymous	MAP/microtubule affinity-regulating kinase 2;MARK2;MAP/microtubule affinity-regulating kinase 2
Definition	ELKL motif kinase 1\|PAR1 homolog b\|Ser/Thr protein kinase PAR-1B\|serine/threonine protein kinase EMK\|serine/threonine-protein kinase MARK2
Position	11q13.1
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
MARK2(h) + ATP --LKB1(m):STRADalpha(h):MO25(h)--> MARK2(h){pT175} + ADP (phosphorylation)
MARK2(h) + ATP --LKB1(m):STRADalpha(h):MO25beta(h)--> MARK2(h){pT175} + ADP (phosphorylation)
MARK2(h) + ATP --LKB1(m):STRADbeta(h):MO25(h)--> MARK2(h){pT175} + ADP (phosphorylation)
14-3-3epsilon(h) + 14-3-3zeta(h) + Hsp70-1(h) + MARK2(h) <==> 14-3-3epsilon(h):14-3-3zeta(h):Hsp70-1(h):MARK2(h) (binding)
MARK2(h) --> MARK2(h) (expression).
MARK2(h) --> EMK1-isoform2(h) (expression).
14-3-3gamma(h) + EMK1(h) <==> 14-3-3gamma(h):EMK1(h) (binding)
14-3-3tau(h) + EMK1(h) <==> 14-3-3tau(h):EMK1(h) (binding)
14-3-3sigma(m.s.) + EMK1(h) <==> 14-3-3sigma(m.s.):EMK1(h) (binding)
EMK1(h) + ATP --LKB1(m.s.):STRADbeta(m.s.):MO25(m.s.)--> EMK1(h){pT} + ADP (phosphorylation)
MARK2(h) --> EMK1(h) (expression).
MARK2(h) --> EMK1-isoform3(h) (expression).
MARK2(h) --> EMK1-isoform4(h) (expression).
MARK2(h) --> EMK1-isoform5(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
40	Phosphoserine.		Swiss-Prot 53.0
208	Phosphothreonine.		Swiss-Prot 53.0
212	Phosphoserine (By similarity).		Swiss-Prot 53.0
456	Phosphoserine.		Swiss-Prot 53.0
469	Phosphothreonine.		Swiss-Prot 53.0
479	Phosphoserine.		Swiss-Prot 53.0
486	Phosphoserine.		Swiss-Prot 53.0
569	Phosphoserine.		Swiss-Prot 53.0
571	Phosphoserine.		Swiss-Prot 53.0
596	Phosphothreonine (by PKC/PRKCZ).		Swiss-Prot 53.0
619	Phosphoserine.		Swiss-Prot 53.0
631	Phosphoserine.		Swiss-Prot 53.0
456	Phosphoserine	15302935	Phospho.ELM 6.0
208	Phosphothreonine (LKB1)	14976552	Phospho.ELM 6.0
596	Phosphothreonine (PKC alpha)	15324659	Phospho.ELM 6.0
486	Phosphoserine	17081983	Phospho.ELM 6.0

Transcription Factors [Top]