Entrez Gene

Basic Information
Gene ID	1978
Name	EIF4EBP1
Synonymous	eukaryotic translation initiation factor 4E binding protein 1;EIF4EBP1;eukaryotic translation initiation factor 4E binding protein 1
Definition	eIF4E-binding protein 1\|eukaryotic translation initiation factor 4E-binding protein 1\|phosphorylated heat- and acid-stable protein regulated by insulin 1
Position	8p12
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
raptor(h) + 4E-BP1(h) <==> raptor(h):4E-BP1(h) (binding)
4E-BP1(h) + eIF-4E(h) <==> 4E-BP1(h):eIF-4E(h) (binding)
4E-BP1(h) + ATP --mTOR(m):raptor(h)--> 4E-BP1(h){p} + ADP (phosphorylation)
4E-BP1(h) + ATP --mTOR(r)--> 4E-BP1(h){pT36}{pT45} + ADP (phosphorylation)
4E-BP1(h) + eIF-4E(m) <==> 4E-BP1(h):eIF-4E(m) (binding)
4E-BP1(h) + NTP --mTOR(h)--> 4E-BP1(h){p} + NDP (phosphorylation)
4E-BP1(h) + ATP --> 4E-BP1(h){pT} + ADP (phosphorylation)
4E-BP1(h) + GBDR1(h) <==> 4E-BP1(h):GBDR1(h) (binding)
4E-BP1(h) + CTF8(h) <==> 4E-BP1(h):CTF8(h) (binding)
4E-BP1(h) + ATP --> 4E-BP1(h){pS65} + ADP (phosphorylation)
4E-BP1(h) + ATP --> 4E-BP1(h){pT70} + ADP (phosphorylation)
4E-BP1(h) + ATP --> 4E-BP1(h){p} + ADP (phosphorylation)
EIF4EBP1(h) --> 4E-BP1(h) (expression).
4E-BP1(h){p} --> 4E-BP1(h) + p (dephosphorylation)
4E-BP1(h) + ATP --ATM(m.s.)--> 4E-BP1(h){pS94} + ADP (phosphorylation)
4E-BP1(h) + ATP --ATR(m.s.)--> 4E-BP1(h){pS94} + ADP (phosphorylation)
4E-BP1(h) + ATP --DNA-PK(m.s.)--> 4E-BP1(h){pS94} + ADP (phosphorylation)
4E-BP1(h) + ATP --mTOR(h)--> 4E-BP1(h){pS65} + ADP (phosphorylation)
4E-BP1(h) + ATP --> 4E-BP1(h){pS65} + ADP (phosphorylation)
4E-BP1(h) + eIF4E-1(LEIMAFR) <==> 4E-BP1(h):eIF4E-1(LEIMAFR) (binding)
eIF4E-4(LEIMAFR) + 4E-BP1(h) <==> eIF4E-4(LEIMAFR):4E-BP1(h) (binding)
4E-BP1(h) + eIF-4E(m) <==> 4E-BP1(h):eIF-4E(m) (binding)
EIF4EBP1(h) --> 4E-BP1(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
2	N-acetylserine.		Swiss-Prot 53.0
65	Phosphoserine (by MAPK1 and MAPK3) (Bysimilarity).		Swiss-Prot 53.0
36	Phosphothreonine (mTOR)	12370290	Phospho.ELM 6.0
111	Phosphoserine (ATM)	11146653	Phospho.ELM 6.0
45	Phosphothreonine (mTOR)	12370290	Phospho.ELM 6.0
64	Phosphoserine (mTOR)	12912989;17081983	Phospho.ELM 6.0
69	Phosphothreonine (mTOR)	12370290;12912989;17081983	Phospho.ELM 6.0
82	Phosphoserine (mTOR)	9405468	Phospho.ELM 6.0
100	Phosphoserine (mTOR)	12912989	Phospho.ELM 6.0
7	Phosphoserine (ATM)	10713094	Phospho.ELM 6.0

Transcription Factors [Top]