Entrez Gene

Basic Information
Gene ID	10298
Name	PAK4
Synonymous	p21 protein (Cdc42/Rac)-activated kinase 4;PAK4;p21 protein (Cdc42/Rac)-activated kinase 4
Definition	PAK-4\|p21(CDKN1A)-activated kinase 4\|p21-activated kinase 4\|protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs\|serine/threonine-protein kinase PAK 4
Position	19q13.2
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
Cdc42(h):GTP + PAK4(h) <==> Cdc42(h):GTP:PAK4(h) (binding)
beta5-integrin(mo) + PAK4(h) <==> beta5-integrin(mo):PAK4(h) (binding)
beta5-integrin(h) + PAK4(h) <==> beta5-integrin(h):PAK4(h) (binding)
CD51(mo):beta5-integrin(mo) + PAK4(h) <==> CD51(mo):beta5-integrin(mo):PAK4(h) (binding)
CD51(h):beta5-integrin(h) + PAK4(h) <==> CD51(h):beta5-integrin(h):PAK4(h) (binding)
LFP40(h) + PAK4(h) <==> LFP40(h):PAK4(h) (binding)
14-3-3gamma(h) + PAK4(h) <==> 14-3-3gamma(h):PAK4(h) (binding)
14-3-3tau(h) + PAK4(h) <==> 14-3-3tau(h):PAK4(h) (binding)
PAK4(h) + Cdc42(h) <==> PAK4(h):Cdc42(h) (binding)
14-3-3zeta(h) + PAK4(h) <==> 14-3-3zeta(h):PAK4(h) (binding)
14-3-3sigma(m.s.) + PAK4(h) <==> 14-3-3sigma(m.s.):PAK4(h) (binding)
PAK4(h) + dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial(h) <==> PAK4(h):dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial(h) (binding)
PAK4(h) --> PAK4(h) (expression).
Rac1(m.s.):GTP + PAK4-1(h) <==> Rac1(m.s.):GTP:PAK4-1(h) (binding)
Cdc42(m.s.):GTP + PAK4-1(h) <==> Cdc42(m.s.):GTP:PAK4-1(h) (binding)
PAK4-1(h) + ATP --> PAK4-1(h){p} + ADP (phosphorylation; automodification)
PAK4(h) --> PAK4-1(h) (expression).
LFP40-xbb1(h) + ATP --PAK4-1(h)--> LFP40-xbb1(h){pS810} + ADP (phosphorylation)
PAK4(h) --> PAK4-3(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
99	Phosphoserine.		Swiss-Prot 53.0
104	Phosphoserine.		Swiss-Prot 53.0
148	Phosphoserine.		Swiss-Prot 53.0
167	Phosphoserine.		Swiss-Prot 53.0
181	Phosphoserine.		Swiss-Prot 53.0
207	Phosphothreonine.		Swiss-Prot 53.0
267	Phosphoserine.		Swiss-Prot 53.0
291	Phosphoserine.		Swiss-Prot 53.0
474	Phosphoserine (by autocatalysis).		Swiss-Prot 53.0
474	Phosphoserine	17081983	Phospho.ELM 6.0

Transcription Factors [Top]