Entrez Gene

Basic Information
Gene ID	10188
Name	TNK2
Synonymous	tyrosine kinase, non-receptor, 2;TNK2;tyrosine kinase, non-receptor, 2
Definition	activated CDC42 kinase 1\|activated Cdc42-associated kinase 1\|activated p21cdc42Hs kinase\|tyrosine kinase non-receptor protein 2
Position	3q29
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
ACK-1(h) + ATP --> ACK-1(h){pY} + ADP (phosphorylation)
ACK-1(h) --> KLK3(h) (transactivation)
ACK-1(h) --> KLK2(h) (transactivation)
TNK2(h) --> ACK-1(h) (expression).
ACK-1(h) + ATP --> ACK-1(h){pY284} + ADP (phosphorylation)
ACK-1(h) + ATP --> ACK-1(h){pY} + ADP (phosphorylation)
ACK-1(h) + Src(m.s.) <==> ACK-1(h):Src(m.s.) (binding)
ACK-1(h) + Nck-1(m.s.) <==> ACK-1(h):Nck-1(m.s.) (binding)
ACK-1(h) + Hck(m.s.) <==> ACK-1(h):Hck(m.s.) (binding)
ACK-1(h) + ATP --Hck(m.s.)--> ACK-1(h){pY284} + ADP (phosphorylation)
Grb-2(m.s.) + ACK-1(h) <==> Grb-2(m.s.):ACK-1(h) (binding)
TNK2(h) --> ACK-1(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
149	Phosphoserine.		Swiss-Prot 53.0
518	Phosphotyrosine.		Swiss-Prot 53.0
826	Phosphotyrosine.		Swiss-Prot 53.0
857	Phosphotyrosine.		Swiss-Prot 53.0
858	Phosphotyrosine.		Swiss-Prot 53.0
826	Phosphotyrosine	12522270;17081983	Phospho.ELM 6.0
857	Phosphotyrosine	12522270	Phospho.ELM 6.0
858	Phosphotyrosine	12522270	Phospho.ELM 6.0
518	Phosphotyrosine	15592455	Phospho.ELM 6.0
284	Phosphotyrosine (TNK2)	14506255;16472662	Phospho.ELM 6.0

Transcription Factors [Top]