Entrez Gene

Basic Information
Gene ID	9722
Name	NOS1AP
Synonymous	nitric oxide synthase 1 (neuronal) adaptor protein;NOS1AP;nitric oxide synthase 1 (neuronal) adaptor protein
Definition	C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON)\|C-terminal PDZ ligand of neuronal nitric oxide synthase protein\|carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein\|ligand of neuronal nitric oxide synthase with car
Position	1q23.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1304C>T; p.P435L; 1:162367250-162367250	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.433G>A; p.V145I; 1:162333105-162333105	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.767C>T; p.S256L; 1:162356964-162356964	skin	malignant_melanoma	Substitution - Missense
c.1410G>A; p.T470T; 1:162367356-162367356	skin	malignant_melanoma	Substitution - coding silent
c.595+1G>C; p.?; 1:162343977-162343977	lung	carcinoma; adenocarcinoma	Unknown
c.1386C>T; p.I462I; 1:162367332-162367332	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1335C>T; p.G445G; 1:162367281-162367281	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1516G>A; p.V506M; 1:162367462-162367462	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.380A>G; p.K127R; 1:162333052-162333052	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.425G>C; p.R142T; 1:162333097-162333097	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.736G>A; p.E246K; 1:162355327-162355327	skin	malignant_melanoma	Substitution - Missense
c.1362C>T; p.L454L; 1:162367308-162367308	skin	malignant_melanoma	Substitution - coding silent
c.557G>A; p.G186E; 1:162343938-162343938	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.736G>A; p.E246K; 1:162355327-162355327	skin	malignant_melanoma	Substitution - Missense
c.341A>G; p.Y114C; 1:162300703-162300703	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.450G>C; p.K150N; 1:162333122-162333122	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.797C>T; p.S266L; 1:162356994-162356994	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.415A>C; p.N139H; 1:162333087-162333087	skin	malignant_melanoma	Substitution - Missense
c.844G>A; p.G282S; 1:162357041-162357041	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.511C>T; p.L171L; 1:162343892-162343892	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.73G>A; p.A25T; 1:162070250-162070250	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1195C>A; p.L399M; 1:162367141-162367141	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.808C>T; p.L270L; 1:162357005-162357005	oesophagus	carcinoma	Substitution - coding silent
c.685G>A; p.D229N; 1:162355276-162355276	skin	malignant_melanoma	Substitution - Missense
c.774C>T; p.P258P; 1:162356971-162356971	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.901_903delCAG; p.Q306delQ; 1:162357098-162357100	skin	malignant_melanoma	Deletion - In frame
c.901_903delCAG; p.Q306delQ; 1:162357098-162357100	NS	malignant_melanoma	Deletion - In frame
c.901_903delCAG; p.Q306delQ; 1:162357098-162357100	skin	malignant_melanoma	Deletion - In frame
c.1405A>G; p.N469D; 1:162367351-162367351	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1350C>T; p.G450G; 1:162367296-162367296	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1350C>T; p.G450G; 1:162367296-162367296	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1002C>T; p.R334R; 1:162365466-162365466	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1002C>T; p.R334R; 1:162365466-162365466	thyroid	other; neoplasm	Substitution - coding silent
c.558A>G; p.G186G; 1:162343939-162343939	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1191G>T; p.E397D; 1:162367137-162367137	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1336G>C; p.E446Q; 1:162367282-162367282	urinary_tract; bladder	carcinoma	Substitution - Missense
c.527C>T; p.T176M; 1:162343908-162343908	central_nervous_system; brain	glioma	Substitution - Missense
c.596G>T; p.G199V; 1:162355187-162355187	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.230C>A; p.S77*; 1:162287396-162287396	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.732G>A; p.G244G; 1:162355323-162355323	skin	malignant_melanoma	Substitution - coding silent
c.596-1G>A; p.?; 1:162355186-162355186	skin	malignant_melanoma	Unknown
c.1340C>T; p.A447V; 1:162367286-162367286	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.980C>G; p.A327G; 1:162365444-162365444	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.694G>A; p.E232K; 1:162355285-162355285	skin	malignant_melanoma	Substitution - Missense
c.397G>T; p.A133S; 1:162333069-162333069	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.715G>A; p.D239N; 1:162355306-162355306	skin	malignant_melanoma	Substitution - Missense
c.469A>G; p.I157V; 1:162343850-162343850	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1059C>T; p.V353V; 1:162365523-162365523	skin	malignant_melanoma	Substitution - coding silent
c.1121G>A; p.S374N; 1:162367067-162367067	skin	malignant_melanoma	Substitution - Missense
c.1446G>T; p.E482D; 1:162367392-162367392	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.156G>A; p.V52V; 1:162154455-162154455	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.1204C>T; p.P402S; 1:162367150-162367150	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.823T>C; p.S275P; 1:162357020-162357020	oesophagus	carcinoma	Substitution - Missense
c.1044C>T; p.H348H; 1:162365508-162365508	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1272C>T; p.C424C; 1:162367218-162367218	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.486G>A; p.G162G; 1:162343867-162343867	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.344G>A; p.R115K; 1:162300706-162300706	skin	malignant_melanoma	Substitution - Missense
c.1483G>A; p.E495K; 1:162367429-162367429	skin	malignant_melanoma	Substitution - Missense
c.1483G>A; p.E495K; 1:162367429-162367429	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.564C>T; p.S188S; 1:162343945-162343945	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1386C>A; p.I462I; 1:162367332-162367332	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.667G>A; p.V223I; 1:162355258-162355258	pancreas	carcinoma	Substitution - Missense
c.811C>T; p.L271F; 1:162357008-162357008	breast	carcinoma	Substitution - Missense
c.1113C>A; p.S371S; 1:162367059-162367059	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.703C>T; p.R235*; 1:162355294-162355294	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1226C>T; p.A409V; 1:162367172-162367172	skin	malignant_melanoma	Substitution - Missense
c.1038C>T; p.L346L; 1:162365502-162365502	breast	carcinoma	Substitution - coding silent
c.1001G>A; p.R334H; 1:162365465-162365465	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.472G>T; p.V158F; 1:162343853-162343853	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.700A>G; p.S234G; 1:162355291-162355291	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.471C>T; p.I157I; 1:162343852-162343852	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.255_257delGAA; p.K90delK; 1:162287421-162287423	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - In frame
c.794C>A; p.A265D; 1:162356991-162356991	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.611G>C; p.G204A; 1:162355202-162355202	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.893A>T; p.Q298L; 1:162357090-162357090	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1003G>A; p.V335M; 1:162365467-162365467	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.176G>A; p.R59Q; 1:162154475-162154475	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1258G>A; p.G420S; 1:162367204-162367204	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.292G>A; p.E98K; 1:162300654-162300654	skin	malignant_melanoma	Substitution - Missense
c.378G>A; p.L126L; 1:162333050-162333050	breast	carcinoma	Substitution - coding silent
c.1423G>A; p.E475K; 1:162367369-162367369	breast	carcinoma	Substitution - Missense
c.750C>T; p.H250H; 1:162355341-162355341	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1101C>T; p.N367N; 1:162365565-162365565	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.157G>A; p.A53T; 1:162154456-162154456	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.157G>A; p.A53T; 1:162154456-162154456	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1012C>A; p.L338I; 1:162365476-162365476	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.157G>A; p.A53T; 1:162154456-162154456	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.157G>T; p.A53S; 1:162154456-162154456	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.981G>A; p.A327A; 1:162365445-162365445	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.475C>T; p.R159W; 1:162343856-162343856	skin	malignant_melanoma	Substitution - Missense
c.475C>T; p.R159W; 1:162343856-162343856	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.756C>A; p.G252G; 1:162355347-162355347	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.666G>T; p.E222D; 1:162355257-162355257	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1202C>T; p.S401L; 1:162367148-162367148	skin	malignant_melanoma	Substitution - Missense
c.828G>A; p.S276S; 1:162357025-162357025	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.646A>T; p.T216S; 1:162355237-162355237	skin	malignant_melanoma	Substitution - Missense
c.940-8C>A; p.?; 1:162365396-162365396	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.167G>A; p.R56H; 1:162154466-162154466	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.167G>A; p.R56H; 1:162154466-162154466	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.243G>A; p.V81V; 1:162287409-162287409	breast	carcinoma	Substitution - coding silent
c.109G>T; p.V37L; 1:162154408-162154408	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.99G>A; p.E33E; 1:162070276-162070276	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.477G>A; p.R159R; 1:162343858-162343858	skin	malignant_melanoma	Substitution - coding silent
c.706G>T; p.G236C; 1:162355297-162355297	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.467G>A; p.R156K; 1:162343848-162343848	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.467G>A; p.R156K; 1:162343848-162343848	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1423G>T; p.E475*; 1:162367369-162367369	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1129G>A; p.E377K; 1:162367075-162367075	skin	malignant_melanoma	Substitution - Missense
c.735G>T; p.K245N; 1:162355326-162355326	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.441A>T; p.K147N; 1:162333113-162333113	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.735G>T; p.K245N; 1:162355326-162355326	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.153C>T; p.I51I; 1:162154452-162154452	skin	malignant_melanoma	Substitution - coding silent
c.565G>A; p.E189K; 1:162343946-162343946	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.415A>T; p.N139Y; 1:162333087-162333087	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.718C>T; p.L240L; 1:162355309-162355309	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.826T>C; p.S276P; 1:162357023-162357023	breast	carcinoma	Substitution - Missense
c.555_556TG>GC; p.D185_G186>ER; 1:162343936-162343937	lung	carcinoma; adenocarcinoma	Complex - compound substitution
c.272T>G; p.L91R; 1:162300634-162300634	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1275G>C; p.L425F; 1:162367221-162367221	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.274C>A; p.L92I; 1:162300636-162300636	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1012C>T; p.L338F; 1:162365476-162365476	skin	malignant_melanoma	Substitution - Missense
c.1306_1307CC>TT; p.P436F; 1:162367252-162367253	skin	malignant_melanoma	Substitution - Missense
c.1428C>A; p.R476R; 1:162367374-162367374	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.96T>C; p.F32F; 1:162070273-162070273	NS	NS	Substitution - coding silent
c.314A>T; p.K105M; 1:162300676-162300676	breast	carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]