Entrez Gene

Basic Information
Gene ID	7448
Name	VTN
Synonymous	vitronectin;VTN;vitronectin
Definition	S-protein\|complement S-protein\|epibolin\|serum spreading factor\|serum-spreading factor\|somatomedin B
Position	17q11
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.590G>A; p.R197Q; 17:28369368-28369368	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.607G>A; p.E203K; 17:28369351-28369351	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.615C>T; p.P205P; 17:28369343-28369343	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.607G>A; p.E203K; 17:28369351-28369351	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.590G>A; p.R197Q; 17:28369368-28369368	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.553G>A; p.E185K; 17:28369405-28369405	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.553G>A; p.E185K; 17:28369405-28369405	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.686G>A; p.R229H; 17:28369012-28369012	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.371C>T; p.A124V; 17:28369665-28369665	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.504G>A; p.K168K; 17:28369532-28369532	skin	malignant_melanoma	Substitution - coding silent
c.643T>A; p.C215S; 17:28369315-28369315	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.632C>T; p.T211I; 17:28369326-28369326	skin	malignant_melanoma	Substitution - Missense
c.1085G>A; p.R362H; 17:28367954-28367954	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1192C>A; p.R398S; 17:28367847-28367847	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.56C>A; p.A19D; 17:28370148-28370148	breast	carcinoma	Substitution - Missense
c.685C>T; p.R229C; 17:28369013-28369013	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.487G>A; p.A163T; 17:28369549-28369549	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.18C>A; p.P6P; 17:28370186-28370186	liver	carcinoma	Substitution - coding silent
c.530-10T>G; p.?; 17:28369438-28369438	liver	carcinoma	Unknown
c.124G>A; p.E42K; 17:28369987-28369987	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.530-10T>G; p.?; 17:28369438-28369438	liver	carcinoma	Unknown
c.1411G>C; p.G471R; 17:28367395-28367395	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.759C>T; p.N253N; 17:28368939-28368939	large_intestine; rectum	NS	Substitution - coding silent
c.759C>T; p.N253N; 17:28368939-28368939	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.661C>G; p.L221V; 17:28369297-28369297	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.277_278insG; p.V93fs*9; 17:28369758-28369759	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Insertion - Frameshift
c.855G>A; p.Q285Q; 17:28368645-28368645	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1184G>A; p.R395Q; 17:28367855-28367855	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1129A>G; p.K377E; 17:28367910-28367910	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.742G>A; p.D248N; 17:28368956-28368956	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.759C>A; p.N253K; 17:28368939-28368939	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.287C>T; p.P96L; 17:28369749-28369749	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.305T>C; p.L102P; 17:28369731-28369731	liver	carcinoma	Substitution - Missense
c.305T>C; p.L102P; 17:28369731-28369731	liver	carcinoma	Substitution - Missense
c.967G>A; p.G323S; 17:28368533-28368533	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1042G>A; p.A348T; 17:28367997-28367997	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1166G>A; p.R389H; 17:28367873-28367873	pancreas	carcinoma	Substitution - Missense
c.1166G>A; p.R389H; 17:28367873-28367873	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1319C>G; p.S440C; 17:28367720-28367720	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1319C>G; p.S440C; 17:28367720-28367720	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.193G>A; p.G65R; 17:28369843-28369843	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1182C>T; p.R394R; 17:28367857-28367857	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.808C>A; p.R270R; 17:28368890-28368890	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.919A>G; p.M307V; 17:28368581-28368581	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.430C>T; p.P144S; 17:28369606-28369606	breast	carcinoma	Substitution - Missense
c.24C>A; p.L8L; 17:28370180-28370180	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1337G>A; p.R446Q; 17:28367469-28367469	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.808C>T; p.R270W; 17:28368890-28368890	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.874_876delGAG; p.E292delE; 17:28368624-28368626	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.808C>T; p.R270W; 17:28368890-28368890	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.789T>C; p.H263H; 17:28368909-28368909	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.79C>T; p.R27C; 17:28370032-28370032	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.508G>C; p.G170R; 17:28369528-28369528	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.634C>T; p.R212C; 17:28369324-28369324	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.708C>A; p.D236E; 17:28368990-28368990	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.819C>G; p.F273L; 17:28368879-28368879	breast	carcinoma	Substitution - Missense
c.606C>T; p.I202I; 17:28369352-28369352	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1348C>T; p.R450C; 17:28367458-28367458	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1229G>A; p.S410N; 17:28367810-28367810	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.10C>A; p.L4M; 17:28370194-28370194	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.430C>G; p.P144A; 17:28369606-28369606	liver	carcinoma	Substitution - Missense
c.1148G>A; p.R383Q; 17:28367891-28367891	skin	malignant_melanoma	Substitution - Missense
c.746G>A; p.G249D; 17:28368952-28368952	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.705G>A; p.L235L; 17:28368993-28368993	skin	malignant_melanoma	Substitution - coding silent
c.430C>G; p.P144A; 17:28369606-28369606	liver	carcinoma	Substitution - Missense
c.27A>G; p.I9M; 17:28370177-28370177	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.383G>C; p.G128A; 17:28369653-28369653	thyroid	carcinoma	Substitution - Missense
c.1016G>A; p.W339*; 17:28368023-28368023	skin	malignant_melanoma	Substitution - Nonsense
c.483C>T; p.F161F; 17:28369553-28369553	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.714T>G; p.D238E; 17:28368984-28368984	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.793T>C; p.Y265H; 17:28368905-28368905	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.714T>G; p.D238E; 17:28368984-28368984	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.718C>T; p.P240S; 17:28368980-28368980	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.120T>C; p.C40C; 17:28369991-28369991	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.376G>A; p.E126K; 17:28369660-28369660	skin	malignant_melanoma	Substitution - Missense
c.238G>A; p.D80N; 17:28369798-28369798	skin	malignant_melanoma	Substitution - Missense
c.722G>A; p.R241Q; 17:28368976-28368976	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.315G>C; p.Q105H; 17:28369721-28369721	ovary	other; neoplasm	Substitution - Missense
c.484G>A; p.D162N; 17:28369552-28369552	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1393A>C; p.I465L; 17:28367413-28367413	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.372G>A; p.A124A; 17:28369664-28369664	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1320T>A; p.S440S; 17:28367719-28367719	pancreas	carcinoma	Substitution - coding silent
c.372G>A; p.A124A; 17:28369664-28369664	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1320T>A; p.S440S; 17:28367719-28367719	pancreas	carcinoid-endocrine_tumour	Substitution - coding silent
c.1199C>T; p.T400M; 17:28367840-28367840	thyroid	other; neoplasm	Substitution - Missense
c.720C>G; p.P240P; 17:28368978-28368978	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1387C>T; p.R463C; 17:28367419-28367419	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1180C>T; p.R394C; 17:28367859-28367859	oesophagus	carcinoma	Substitution - Missense
c.752C>T; p.P251L; 17:28368946-28368946	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.527G>A; p.R176Q; 17:28369509-28369509	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1349G>A; p.R450H; 17:28367457-28367457	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1349G>A; p.R450H; 17:28367457-28367457	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.384C>T; p.G128G; 17:28369652-28369652	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.410C>G; p.S137*; 17:28369626-28369626	urinary_tract; bladder	carcinoma	Substitution - Nonsense

COSMIC somatic mutation [Top]