Entrez Gene

Basic Information
Gene ID	7168
Name	TPM1
Synonymous	tropomyosin 1 (alpha);TPM1;tropomyosin 1 (alpha)
Definition	alpha-tropomyosin\|cardiomyopathy, hypertrophic 3\|sarcomeric tropomyosin kappa\|tropomyosin alpha-1 chain
Position	15q22.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.645G>A; p.S215S; 15:63062220-63062220	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.591G>C; p.L197F; 15:63061740-63061740	skin	malignant_melanoma	Substitution - Missense
c.574G>A; p.E192K; 15:63061723-63061723	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.569G>C; p.C190S; 15:63061718-63061718	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.162G>A; p.E54E; 15:63043753-63043753	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.15G>A; p.K5K; 15:63042844-63042844	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.703-1G>A; p.?; 15:63062575-63062575	central_nervous_system; brain	glioma	Unknown
c.475G>A; p.D159N; 15:63059663-63059663	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.670G>C; p.E224Q; 15:63062245-63062245	urinary_tract; bladder	carcinoma	Substitution - Missense
c.586G>T; p.E196*; 15:63061735-63061735	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.478C>T; p.R160C; 15:63059666-63059666	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.607A>G; p.N203D; 15:63061756-63061756	liver	carcinoma	Substitution - Missense
c.572C>T; p.A191V; 15:63061721-63061721	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.607A>G; p.N203D; 15:63061756-63061756	liver	carcinoma	Substitution - Missense
c.129C>A; p.I43I; 15:63043720-63043720	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.463G>C; p.A155P; 15:63059651-63059651	breast	carcinoma	Substitution - Missense
c.526C>A; p.L176M; 15:63060902-63060902	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.36G>C; p.K12N; 15:63042865-63042865	skin	malignant_melanoma	Substitution - Missense
c.708G>C; p.E236D; 15:63062581-63062581	breast	carcinoma	Substitution - Missense
c.284T>G; p.V95G; 15:63057028-63057028	skin	malignant_melanoma	Substitution - Missense
c.316C>T; p.L106L; 15:63057060-63057060	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.782C>A; p.A261D; 15:63071099-63071099	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.522C>T; p.S174S; 15:63060898-63060898	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.75G>A; p.A25A; 15:63042904-63042904	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; follicular_lymphoma	Substitution - coding silent
c.403C>A; p.Q135K; 15:63059591-63059591	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.301C>T; p.R101C; 15:63057045-63057045	skin	malignant_melanoma	Substitution - Missense
c.352A>T; p.K118*; 15:63057096-63057096	skin	malignant_melanoma	Substitution - Nonsense
c.76G>A; p.E26K; 15:63042905-63042905	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.76G>A; p.E26K; 15:63042905-63042905	urinary_tract; bladder	carcinoma	Substitution - Missense
c.544C>T; p.R182W; 15:63060920-63060920	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.499C>G; p.R167G; 15:63060875-63060875	breast	carcinoma	Substitution - Missense
c.107G>A; p.S36N; 15:63042936-63042936	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.824A>T; p.D275V; 15:63071141-63071141	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.497C>T; p.A166V; 15:63060873-63060873	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.438C>G; p.I146M; 15:63059626-63059626	pancreas	carcinoma	Substitution - Missense
c.593A>G; p.K198R; 15:63061742-63061742	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.486T>C; p.Y162Y; 15:63059674-63059674	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.567A>T; p.K189N; 15:63061716-63061716	skin	malignant_melanoma	Substitution - Missense
c.453C>A; p.A151A; 15:63059641-63059641	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.493-2A>G; p.?; 15:63060867-63060867	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.632C>T; p.A211V; 15:63061781-63061781	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.629A>G; p.Q210R; 15:63061778-63061778	stomach	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]