Entrez Gene

Basic Information
Gene ID	60
Name	ACTB
Synonymous	actin, beta;ACTB;actin, beta
Definition	PS1TP5-binding protein 1\|actin, cytoplasmic 1\|beta cytoskeletal actin
Position	7p22
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.155C>T; p.S52F; 7:5529369-5529369	NS	malignant_melanoma	Substitution - Missense
c.185G>C; p.R62T; 7:5529339-5529339	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1034T>C; p.I345T; 7:5527842-5527842	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.669C>A; p.F223L; 7:5528414-5528414	urinary_tract; bladder	carcinoma	Substitution - Missense
c.669C>A; p.F223L; 7:5528414-5528414	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.147G>A; p.Q49Q; 7:5529377-5529377	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.147G>A; p.Q49Q; 7:5529377-5529377	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.35A>G; p.N12S; 7:5529623-5529623	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.778G>A; p.A260T; 7:5528305-5528305	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.145C>T; p.Q49*; 7:5529379-5529379	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.778G>A; p.A260T; 7:5528305-5528305	prostate	carcinoma	Substitution - Missense
c.298G>A; p.E100K; 7:5529226-5529226	skin	malignant_melanoma	Substitution - Missense
c.382A>G; p.N128D; 7:5528701-5528701	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.277G>C; p.E93Q; 7:5529247-5529247	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1040C>G; p.A347G; 7:5527836-5527836	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1000G>A; p.E334K; 7:5527876-5527876	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1000G>A; p.E334K; 7:5527876-5527876	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1000G>A; p.E334K; 7:5527876-5527876	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.720delC; p.Y240fs*1; 7:5528363-5528363	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.284G>A; p.R95H; 7:5529240-5529240	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.284G>A; p.R95H; 7:5529240-5529240	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.284G>A; p.R95H; 7:5529240-5529240	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.395T>C; p.M132T; 7:5528688-5528688	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.164G>C; p.G55A; 7:5529360-5529360	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.496T>C; p.Y166H; 7:5528587-5528587	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.59G>C; p.G20A; 7:5529599-5529599	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.440G>A; p.R147H; 7:5528643-5528643	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.660C>T; p.A220A; 7:5528423-5528423	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.590G>A; p.G197D; 7:5528493-5528493	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.515C>G; p.P172R; 7:5528568-5528568	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.703T>C; p.S235P; 7:5528380-5528380	thyroid	other; neoplasm	Substitution - Missense
c.770G>C; p.C257S; 7:5528313-5528313	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.642G>A; p.E214E; 7:5528441-5528441	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.272A>G; p.Y91C; 7:5529252-5529252	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1038delG; p.A347fs*>29; 7:5527838-5527838	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.761G>A; p.R254Q; 7:5528322-5528322	breast	carcinoma	Substitution - Missense
c.272A>G; p.Y91C; 7:5529252-5529252	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.124-1G>C; p.?; 7:5529401-5529401	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.124-1G>C; p.?; 7:5529401-5529401	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.124-1G>C; p.?; 7:5529401-5529401	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.124-1G>C; p.?; 7:5529401-5529401	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.124-1G>C; p.?; 7:5529401-5529401	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.124-1G>C; p.?; 7:5529401-5529401	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.124-1G>C; p.?; 7:5529401-5529401	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.124-1G>C; p.?; 7:5529401-5529401	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.124-1G>C; p.?; 7:5529401-5529401	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.124-1G>C; p.?; 7:5529401-5529401	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.124-1G>C; p.?; 7:5529401-5529401	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.864C>T; p.D288D; 7:5528124-5528124	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.747C>T; p.T249T; 7:5528336-5528336	pancreas	carcinoma	Substitution - coding silent
c.628C>T; p.R210C; 7:5528455-5528455	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.719A>G; p.Y240C; 7:5528364-5528364	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.99C>T; p.S33S; 7:5529559-5529559	skin	malignant_melanoma	Substitution - coding silent
c.1017G>A; p.V339V; 7:5527859-5527859	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.416T>C; p.V139A; 7:5528667-5528667	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.416T>C; p.V139A; 7:5528667-5528667	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.166G>A; p.D56N; 7:5529358-5529358	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.859G>A; p.V287M; 7:5528129-5528129	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.775G>A; p.E259K; 7:5528308-5528308	urinary_tract; bladder	carcinoma	Substitution - Missense
c.424C>T; p.L142L; 7:5528659-5528659	liver	carcinoma	Substitution - coding silent
c.424C>T; p.L142L; 7:5528659-5528659	liver	carcinoma	Substitution - coding silent
c.63C>T; p.F21F; 7:5529595-5529595	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.57C>G; p.A19A; 7:5529601-5529601	liver	carcinoma	Substitution - coding silent
c.57C>G; p.A19A; 7:5529601-5529601	liver	carcinoma	Substitution - coding silent
c.63C>T; p.F21F; 7:5529595-5529595	skin	malignant_melanoma	Substitution - coding silent
c.400G>A; p.V134I; 7:5528683-5528683	prostate	carcinoma	Substitution - Missense
c.1114C>T; p.R372C; 7:5527762-5527762	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.137G>T; p.G46V; 7:5529387-5529387	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.978G>A; p.K326K; 7:5528010-5528010	pancreas	carcinoma	Substitution - coding silent
c.670G>C; p.E224Q; 7:5528413-5528413	breast	carcinoma	Substitution - Missense
c.670G>C; p.E224Q; 7:5528413-5528413	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1055_1056insA; p.F352fs*12; 7:5527820-5527821	salivary_gland; tongue	carcinoma; adenoid_cystic_carcinoma	Insertion - Frameshift
c.1033A>G; p.I345V; 7:5527843-5527843	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.881A>G; p.Y294C; 7:5528107-5528107	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.472G>A; p.G158R; 7:5528611-5528611	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.472G>A; p.G158R; 7:5528611-5528611	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.472G>A; p.G158R; 7:5528611-5528611	urinary_tract; bladder	carcinoma	Substitution - Missense
c.472G>A; p.G158R; 7:5528611-5528611	urinary_tract; bladder	carcinoma	Substitution - Missense
c.472G>A; p.G158R; 7:5528611-5528611	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1043C>T; p.S348L; 7:5527833-5527833	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1043C>T; p.S348L; 7:5527833-5527833	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1043C>T; p.S348L; 7:5527833-5527833	urinary_tract; bladder	carcinoma	Substitution - Missense
c.903C>T; p.G301G; 7:5528085-5528085	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.77C>T; p.A26V; 7:5529581-5529581	skin	malignant_melanoma	Substitution - Missense
c.478A>G; p.T160A; 7:5528605-5528605	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1042T>C; p.S348P; 7:5527834-5527834	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.178A>G; p.S60G; 7:5529346-5529346	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.24C>A; p.L8L; 7:5529634-5529634	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.962C>T; p.A321V; 7:5528026-5528026	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.77C>A; p.A26D; 7:5529581-5529581	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1062G>C; p.Q354H; 7:5527814-5527814	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.373G>A; p.E125K; 7:5528710-5528710	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.373G>A; p.E125K; 7:5528710-5528710	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1033A>C; p.I345L; 7:5527843-5527843	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1033A>C; p.I345L; 7:5527843-5527843	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.82delC; p.R28fs*16; 7:5529576-5529576	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.277G>A; p.E93K; 7:5529247-5529247	salivary_gland; tongue	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.162G>T; p.V54V; 7:5529362-5529362	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.455T>C; p.V152A; 7:5528628-5528628	kidney	other; neoplasm	Substitution - Missense
c.302A>G; p.H101R; 7:5529222-5529222	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.124-1G>T; p.?; 7:5529401-5529401	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.1014C>T; p.S338S; 7:5527862-5527862	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.776A>C; p.E259A; 7:5528307-5528307	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.757G>A; p.E253K; 7:5528326-5528326	urinary_tract; bladder	carcinoma	Substitution - Missense
c.516C>T; p.P172P; 7:5528567-5528567	skin	malignant_melanoma	Substitution - coding silent
c.1043C>G; p.S348W; 7:5527833-5527833	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1068G>C; p.W356C; 7:5527808-5527808	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.82C>A; p.R28R; 7:5529576-5529576	breast	carcinoma	Substitution - coding silent
c.598T>G; p.F200V; 7:5528485-5528485	thyroid	carcinoma	Substitution - Missense
c.1004G>C; p.R335P; 7:5527872-5527872	breast	carcinoma	Substitution - Missense
c.1031C>G; p.S344C; 7:5527845-5527845	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1031C>G; p.S344C; 7:5527845-5527845	urinary_tract; bladder	carcinoma	Substitution - Missense
c.33C>G; p.D11E; 7:5529625-5529625	haematopoietic_and_lymphoid_tissue; abdomen	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.772C>T; p.P258S; 7:5528311-5528311	skin	malignant_melanoma	Substitution - Missense
c.658G>A; p.A220T; 7:5528425-5528425	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.484A>G; p.T162A; 7:5528599-5528599	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.364-1G>T; p.?; 7:5528720-5528720	breast	carcinoma	Unknown
c.661C>T; p.L221L; 7:5528422-5528422	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.591C>A; p.G197G; 7:5528492-5528492	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.180C>G; p.S60R; 7:5529344-5529344	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1107C>G; p.I369M; 7:5527769-5527769	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.340G>A; p.A114T; 7:5529184-5529184	skin	malignant_melanoma	Substitution - Missense
c.434C>T; p.S145F; 7:5528649-5528649	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.434C>T; p.S145F; 7:5528649-5528649	urinary_tract; bladder	carcinoma	Substitution - Missense
c.586C>T; p.R196C; 7:5528497-5528497	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.504delG; p.Y169fs*17; 7:5528579-5528579	liver	carcinoma	Deletion - Frameshift

COSMIC somatic mutation [Top]