Cancer metastasis gene database Home
Cancer metastasis database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

5771

Name

PTPN2

Synonymous

protein tyrosine phosphatase, non-receptor type 2;PTPN2;protein tyrosine phosphatase, non-receptor type 2

Definition

T-cell protein tyrosine phosphatase|tyrosine-protein phosphatase non-receptor type 2

Position

18p11.3-p11.2

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.76C>T; p.R26*; 18:12859248-12859248

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.76C>T; p.R26*; 18:12859248-12859248

 skinmalignant_melanomaSubstitution - Nonsense

c.1009A>G; p.M337V; 18:12802001-12802001

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.764G>A; p.R255Q; 18:12814297-12814297

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.408T>C; p.F136F; 18:12825897-12825897

 skin; upper_legmalignant_melanomaSubstitution - coding silent

c.905A>T; p.D302V; 18:12802105-12802105

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.235G>A; p.A79T; 18:12836817-12836817

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.193G>C; p.E65Q; 18:12836859-12836859

 breastcarcinomaSubstitution - Missense

c.1194T>A; p.I398I; 18:12794332-12794332

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.893C>A; p.S298Y; 18:12802117-12802117

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.308A>C; p.Q103P; 18:12830995-12830995

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.340C>T; p.R114C; 18:12830963-12830963

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1053delA; p.K351fs*18; 18:12794473-12794473

 central_nervous_system; brainglioma; astrocytoma_Grade_IVDeletion - Frameshift

c.863G>A; p.R288Q; 18:12802147-12802147

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.706A>C; p.M236L; 18:12814355-12814355

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.673A>C; p.T225P; 18:12817188-12817188

 breastcarcinomaSubstitution - Missense

c.686T>C; p.V229A; 18:12817175-12817175

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.49C>T; p.R17C; 18:12884093-12884093

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.781A>G; p.T261A; 18:12814280-12814280

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.312G>T; p.Q104H; 18:12830991-12830991

 livercarcinomaSubstitution - Missense

c.1204G>A; p.A402T; 18:12794322-12794322

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.16G>C; p.E6Q; 18:12884126-12884126

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.895C>T; p.P299S; 18:12802115-12802115

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.546T>G; p.D182E; 18:12817315-12817315

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.895C>T; p.P299S; 18:12802115-12802115

 skinmalignant_melanomaSubstitution - Missense

c.824G>A; p.G275E; 18:12814237-12814237

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.879T>C; p.S293S; 18:12802131-12802131

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1142G>T; p.R381M; 18:12794384-12794384

 ovaryother; neoplasmSubstitution - Missense

c.1074G>A; p.K358K; 18:12794452-12794452

 skinmalignant_melanomaSubstitution - coding silent

c.937T>C; p.Y313H; 18:12802073-12802073

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.665G>A; p.R222H; 18:12817196-12817196

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1060C>T; p.R354*; 18:12794466-12794466

 skinmalignant_melanomaSubstitution - Nonsense

c.1060C>T; p.R354*; 18:12794466-12794466

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.82G>A; p.E28K; 18:12859242-12859242

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.385A>T; p.T129S; 18:12825920-12825920

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.137A>G; p.N46S; 18:12859187-12859187

 livercarcinomaSubstitution - Missense

c.585C>A; p.F195L; 18:12817276-12817276

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.309G>A; p.Q103Q; 18:12830994-12830994

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1063G>T; p.E355*; 18:12794463-12794463

 livercarcinomaSubstitution - Nonsense

c.663G>T; p.G221G; 18:12817198-12817198

 prostatecarcinomaSubstitution - coding silent

c.661G>T; p.G221W; 18:12817200-12817200

 thyroidcarcinomaSubstitution - Missense

c.341G>A; p.R114H; 18:12830962-12830962

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.715G>A; p.G239R; 18:12814346-12814346

 skin; extremitymalignant_melanomaSubstitution - Missense

c.803C>T; p.S268L; 18:12814258-12814258

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.365A>G; p.K122R; 18:12825940-12825940

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.925A>G; p.M309V; 18:12802085-12802085

 livercarcinomaSubstitution - Missense

c.925A>G; p.M309V; 18:12802085-12802085

 livercarcinomaSubstitution - Missense

c.839A>G; p.K280R; 18:12814222-12814222

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.839A>G; p.K280R; 18:12814222-12814222

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.839A>G; p.K280R; 18:12814222-12814222

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.583T>C; p.F195L; 18:12817278-12817278

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1203C>T; p.G401G; 18:12794323-12794323

 skin; nipplemalignant_melanomaSubstitution - coding silent

c.242G>C; p.R81T; 18:12836810-12836810

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.976A>G; p.T326A; 18:12802034-12802034

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.482T>C; p.L161S; 18:12825823-12825823

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.405G>C; p.L135L; 18:12825900-12825900

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.751A>G; p.M251V; 18:12814310-12814310

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; polycythaemia_veraSubstitution - Missense

c.491T>G; p.I164S; 18:12825814-12825814

 breastcarcinomaSubstitution - Missense

c.721G>A; p.D241N; 18:12814340-12814340

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.360+1G>A; p.?; 18:12830942-12830942

 large_intestine; caecumcarcinoma; adenocarcinomaUnknown

c.642C>G; p.I214M; 18:12817219-12817219

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.1027_1029delGAG; p.E343delE; 18:12801981-12801983

 endometriumcarcinoma; endometrioid_carcinomaDeletion - In frame

c.888C>T; p.D296D; 18:12802122-12802122

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.558T>C; p.P186P; 18:12817303-12817303

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.601G>T; p.E201*; 18:12817260-12817260

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.905A>G; p.D302G; 18:12802105-12802105

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1199T>C; p.V400A; 18:12794327-12794327

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense