Entrez Gene

Basic Information
Gene ID	56924
Name	PAK6
Synonymous	p21 protein (Cdc42/Rac)-activated kinase 6;PAK6;p21 protein (Cdc42/Rac)-activated kinase 6
Definition	p21(CDKN1A)-activated kinase 6\|serine/threonine-protein kinase PAK 6
Position	15q14
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.147C>A; p.R49R; 15:40264932-40264932	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.41C>T; p.A14V; 15:40264826-40264826	pancreas	carcinoma	Substitution - Missense
c.1884C>T; p.S628S; 15:40275932-40275932	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.971C>T; p.S324L; 15:40272336-40272336	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.108delC; p.P38fs*30; 15:40264893-40264893	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1423G>A; p.E475K; 15:40272932-40272932	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1879G>A; p.V627I; 15:40275927-40275927	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1847_1848insC; p.P619fs*47; 15:40274245-40274246	breast	carcinoma	Insertion - Frameshift
c.860C>T; p.P287L; 15:40272225-40272225	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1491G>C; p.R497S; 15:40273346-40273346	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.18G>T; p.K6N; 15:40264803-40264803	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.224C>T; p.A75V; 15:40265861-40265861	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.224C>T; p.A75V; 15:40265861-40265861	prostate	carcinoma	Substitution - Missense
c.18G>T; p.K6N; 15:40264803-40264803	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.622delC; p.T210fs*8; 15:40266259-40266259	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1042C>T; p.P348S; 15:40272407-40272407	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.299T>C; p.L100P; 15:40265936-40265936	pancreas	carcinoma	Substitution - Missense
c.2033C>T; p.T678I; 15:40276081-40276081	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1491G>A; p.R497R; 15:40273346-40273346	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2024G>A; p.R675Q; 15:40276072-40276072	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.903C>T; p.S301S; 15:40272268-40272268	skin	malignant_melanoma	Substitution - coding silent
c.2024G>A; p.R675Q; 15:40276072-40276072	liver	carcinoma	Substitution - Missense
c.2024G>A; p.R675Q; 15:40276072-40276072	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2024G>A; p.R675Q; 15:40276072-40276072	liver	carcinoma	Substitution - Missense
c.1928C>T; p.P643L; 15:40275976-40275976	skin	malignant_melanoma	Substitution - Missense
c.308G>A; p.R103H; 15:40265945-40265945	central_nervous_system; brain	glioma	Substitution - Missense
c.1142A>C; p.D381A; 15:40272507-40272507	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.156C>T; p.P52P; 15:40264941-40264941	breast	carcinoma	Substitution - coding silent
c.1629G>A; p.S543S; 15:40273562-40273562	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1135G>T; p.G379C; 15:40272500-40272500	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.827G>A; p.S276N; 15:40266464-40266464	central_nervous_system; brain	glioma; astrocytoma_Grade_II	Substitution - Missense
c.1914G>T; p.M638I; 15:40275962-40275962	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.323G>A; p.R108Q; 15:40265960-40265960	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1958T>C; p.L653P; 15:40276006-40276006	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.688delC; p.Q230fs*27; 15:40266325-40266325	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.8G>A; p.R3H; 15:40264793-40264793	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.644A>G; p.H215R; 15:40266281-40266281	breast	carcinoma	Substitution - Missense
c.679G>A; p.A227T; 15:40266316-40266316	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.753C>T; p.T251T; 15:40266390-40266390	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1057C>T; p.R353C; 15:40272422-40272422	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1598T>G; p.L533R; 15:40273453-40273453	pancreas	carcinoma	Substitution - Missense
c.155C>T; p.P52L; 15:40264940-40264940	skin; shoulder	malignant_melanoma	Substitution - Missense
c.155C>T; p.P52L; 15:40264940-40264940	skin	malignant_melanoma	Substitution - Missense
c.155C>T; p.P52L; 15:40264940-40264940	skin	malignant_melanoma	Substitution - Missense
c.173G>A; p.R58Q; 15:40264958-40264958	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1815C>T; p.S605S; 15:40274213-40274213	skin	malignant_melanoma	Substitution - coding silent
c.1556C>A; p.A519D; 15:40273411-40273411	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.298C>A; p.L100M; 15:40265935-40265935	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1353C>T; p.N451N; 15:40272718-40272718	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1291C>A; p.R431S; 15:40272656-40272656	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.869C>G; p.S290C; 15:40272234-40272234	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1058G>A; p.R353H; 15:40272423-40272423	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1893G>T; p.L631L; 15:40275941-40275941	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1556C>T; p.A519V; 15:40273411-40273411	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1909C>T; p.R637W; 15:40275957-40275957	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.1909C>T; p.R637W; 15:40275957-40275957	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.193C>A; p.Q65K; 15:40264978-40264978	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1653C>T; p.I551I; 15:40273586-40273586	skin	malignant_melanoma	Substitution - coding silent
c.958C>T; p.P320S; 15:40272323-40272323	skin	malignant_melanoma	Substitution - Missense
c.515G>A; p.G172E; 15:40266152-40266152	skin	malignant_melanoma	Substitution - Missense
c.1302C>T; p.A434A; 15:40272667-40272667	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1273C>T; p.R425W; 15:40272638-40272638	skin	malignant_melanoma	Substitution - Missense
c.1168T>C; p.F390L; 15:40272533-40272533	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1921C>T; p.R641W; 15:40275969-40275969	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1491-2A>T; p.?; 15:40273344-40273344	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.1589A>G; p.D530G; 15:40273444-40273444	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1429C>T; p.L477L; 15:40272938-40272938	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1880T>C; p.V627A; 15:40275928-40275928	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.214C>T; p.R72W; 15:40265851-40265851	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.191T>A; p.L64H; 15:40264976-40264976	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1593C>T; p.S531S; 15:40273448-40273448	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.874C>T; p.R292*; 15:40272239-40272239	stomach	adenocarcinoma	Substitution - Nonsense
c.1069G>A; p.A357T; 15:40272434-40272434	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1069G>A; p.A357T; 15:40272434-40272434	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.621G>A; p.S207S; 15:40266258-40266258	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.999C>T; p.L333L; 15:40272364-40272364	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1146A>T; p.T382T; 15:40272511-40272511	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1541T>G; p.L514R; 15:40273396-40273396	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1541T>G; p.L514R; 15:40273396-40273396	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1256G>A; p.G419D; 15:40272621-40272621	pancreas	carcinoma	Substitution - Missense
c.745C>A; p.P249T; 15:40266382-40266382	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1079G>A; p.S360N; 15:40272444-40272444	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1049G>A; p.G350E; 15:40272414-40272414	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2045G>T; p.*682L; 15:40276093-40276093	thyroid	other; neoplasm	Nonstop extension
c.2044T>G; p.*682G; 15:40276092-40276092	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Nonstop extension
c.662A>G; p.K221R; 15:40266299-40266299	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.894delC; p.P300fs*22; 15:40272259-40272259	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.268C>T; p.Q90*; 15:40265905-40265905	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.955A>T; p.S319C; 15:40272320-40272320	breast	carcinoma	Substitution - Missense
c.1060A>C; p.T354P; 15:40272425-40272425	breast	carcinoma	Substitution - Missense
c.50A>C; p.N17T; 15:40264835-40264835	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2008C>T; p.L670L; 15:40276056-40276056	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.318C>T; p.T106T; 15:40265955-40265955	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1929C>T; p.P643P; 15:40275977-40275977	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1922G>A; p.R641Q; 15:40275970-40275970	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.145C>T; p.R49C; 15:40264930-40264930	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1090C>G; p.L364V; 15:40272455-40272455	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.986C>T; p.P329L; 15:40272351-40272351	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.651G>A; p.M217I; 15:40266288-40266288	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.950C>T; p.T317I; 15:40272315-40272315	breast	carcinoma	Substitution - Missense
c.1170C>T; p.F390F; 15:40272535-40272535	breast	carcinoma	Substitution - coding silent
c.1210_1211insC; p.R404fs*97; 15:40272575-40272576	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.594C>T; p.C198C; 15:40266231-40266231	lung	carcinoma; adenocarcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]