Entrez Gene

Basic Information
Gene ID	5624
Name	PROC
Synonymous	protein C (inactivator of coagulation factors Va and VIIIa);PROC;protein C (inactivator of coagulation factors Va and VIIIa)
Definition	anticoagulant protein C\|autoprothrombin IIA\|blood coagulation factor XIV\|prepro-protein C\|vitamin K-dependent protein C
Position	2q13-q14
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.657G>A; p.R219R; 2:127426206-127426206	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1254C>T; p.G418G; 2:127428814-127428814	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.201G>C; p.E67D; 2:127421413-127421413	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1318C>T; p.R440C; 2:127428878-127428878	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.621A>G; p.Q207Q; 2:127426170-127426170	skin	malignant_melanoma	Substitution - coding silent
c.286C>T; p.P96S; 2:127423057-127423057	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.162C>T; p.S54S; 2:127421374-127421374	kidney	other; neoplasm	Substitution - coding silent
c.549T>A; p.C183*; 2:127426098-127426098	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.8A>C; p.Q3P; 2:127419950-127419950	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.714C>T; p.C238C; 2:127427140-127427140	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.714C>T; p.C238C; 2:127427140-127427140	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1299C>T; p.G433G; 2:127428859-127428859	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1195G>A; p.E399K; 2:127428755-127428755	pancreas	carcinoma	Substitution - Missense
c.94C>A; p.R32S; 2:127421306-127421306	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.908T>G; p.L303R; 2:127428468-127428468	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.908T>G; p.L303R; 2:127428468-127428468	skin	malignant_melanoma	Substitution - Missense
c.1043G>A; p.R348Q; 2:127428603-127428603	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.565C>T; p.R189W; 2:127426114-127426114	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.814C>T; p.R272C; 2:127428374-127428374	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.814C>T; p.R272C; 2:127428374-127428374	urinary_tract; bladder	carcinoma	Substitution - Missense
c.814C>T; p.R272C; 2:127428374-127428374	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.859G>A; p.V287I; 2:127428419-127428419	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.852G>A; p.E284E; 2:127428412-127428412	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.820G>A; p.E274K; 2:127428380-127428380	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.9G>A; p.Q3Q; 2:127419951-127419951	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.211G>A; p.E71K; 2:127421423-127421423	skin	malignant_melanoma	Substitution - Missense
c.211G>A; p.E71K; 2:127421423-127421423	skin	malignant_melanoma	Substitution - Missense
c.733C>A; p.P245T; 2:127427159-127427159	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1331G>A; p.W444*; 2:127428891-127428891	skin	malignant_melanoma	Substitution - Nonsense
c.1216A>G; p.M406V; 2:127428776-127428776	breast	carcinoma	Substitution - Missense
c.900C>G; p.I300M; 2:127428460-127428460	thyroid	carcinoma	Substitution - Missense
c.468C>T; p.G156G; 2:127423341-127423341	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1300G>A; p.V434I; 2:127428860-127428860	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.901G>A; p.A301T; 2:127428461-127428461	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.901G>A; p.A301T; 2:127428461-127428461	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.979G>A; p.E327K; 2:127428539-127428539	skin	malignant_melanoma	Substitution - Missense
c.1234G>A; p.G412S; 2:127428794-127428794	pancreas	carcinoma	Substitution - Missense
c.113G>A; p.R38Q; 2:127421325-127421325	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.113G>A; p.R38Q; 2:127421325-127421325	ovary	other; neoplasm	Substitution - Missense
c.837C>T; p.D279D; 2:127428397-127428397	ovary	other; neoplasm	Substitution - coding silent
c.837C>T; p.D279D; 2:127428397-127428397	ovary	other; neoplasm	Substitution - coding silent
c.340G>T; p.G114C; 2:127423111-127423111	large_intestine; colon	carcinoma	Substitution - Missense
c.340G>T; p.G114C; 2:127423111-127423111	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.990C>T; p.L330L; 2:127428550-127428550	skin	malignant_melanoma	Substitution - coding silent
c.25C>T; p.L9L; 2:127419967-127419967	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.219C>T; p.F73F; 2:127421431-127421431	skin	malignant_melanoma	Substitution - coding silent
c.166G>C; p.E56Q; 2:127421378-127421378	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.423G>T; p.S141S; 2:127423296-127423296	thyroid	other; neoplasm	Substitution - coding silent
c.423G>T; p.S141S; 2:127423296-127423296	thyroid	other; neoplasm	Substitution - coding silent
c.888C>G; p.T296T; 2:127428448-127428448	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1191C>A; p.A397A; 2:127428751-127428751	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.969C>T; p.S323S; 2:127428529-127428529	pancreas	carcinoma	Substitution - coding silent
c.220C>T; p.Q74*; 2:127421432-127421432	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1035C>A; p.H345Q; 2:127428595-127428595	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.929C>A; p.T310N; 2:127428489-127428489	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1235G>A; p.G412D; 2:127428795-127428795	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.768T>C; p.D256D; 2:127427194-127427194	thyroid	other; neoplasm	Substitution - coding silent
c.837C>A; p.D279E; 2:127428397-127428397	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1339G>A; p.G447R; 2:127428899-127428899	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1041C>A; p.S347R; 2:127428601-127428601	skin	malignant_melanoma	Substitution - Missense
c.849G>A; p.K283K; 2:127428409-127428409	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1138A>G; p.M380V; 2:127428698-127428698	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.895G>A; p.D299N; 2:127428455-127428455	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.544C>T; p.P182S; 2:127426093-127426093	skin	malignant_melanoma	Substitution - Missense
c.581G>A; p.R194H; 2:127426130-127426130	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1360G>A; p.A454T; 2:127428920-127428920	skin	malignant_melanoma	Substitution - Missense
c.1200C>T; p.G400G; 2:127428760-127428760	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1105C>T; p.P369S; 2:127428665-127428665	skin	malignant_melanoma	Substitution - Missense
c.1105C>T; p.P369S; 2:127428665-127428665	skin	malignant_melanoma	Substitution - Missense
c.1319G>A; p.R440H; 2:127428879-127428879	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.202G>A; p.E68K; 2:127421414-127421414	skin	malignant_melanoma	Substitution - Missense
c.710_711CC>TT; p.A237V; 2:127427136-127427137	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.595C>T; p.R199*; 2:127426144-127426144	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.30C>T; p.F10F; 2:127419972-127419972	pancreas	carcinoma	Substitution - coding silent
c.1369A>C; p.K457Q; 2:127428929-127428929	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.118C>T; p.R40C; 2:127421330-127421330	breast	carcinoma	Substitution - Missense
c.557C>A; p.P186H; 2:127426106-127426106	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1075G>A; p.V359I; 2:127428635-127428635	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1312G>A; p.V438I; 2:127428872-127428872	skin	malignant_melanoma	Substitution - Missense
c.336C>T; p.I112I; 2:127423107-127423107	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1189G>A; p.A397T; 2:127428749-127428749	oesophagus	carcinoma	Substitution - Missense
c.761G>T; p.C254F; 2:127427187-127427187	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.13A>T; p.T5S; 2:127419955-127419955	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1061G>A; p.R354K; 2:127428621-127428621	skin	malignant_melanoma	Substitution - Missense
c.1106C>T; p.P369L; 2:127428666-127428666	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.629C>T; p.P210L; 2:127426178-127426178	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.543C>T; p.F181F; 2:127426092-127426092	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.765G>A; p.M255I; 2:127427191-127427191	skin	malignant_melanoma	Substitution - Missense
c.699G>T; p.K233N; 2:127427125-127427125	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.957C>T; p.C319C; 2:127428517-127428517	skin	malignant_melanoma	Substitution - coding silent
c.43G>A; p.G15R; 2:127419985-127419985	skin	malignant_melanoma	Substitution - Missense

COSMIC somatic mutation [Top]