| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5624 |
Name | PROC |
Synonym | APC|PC|PROC1|THPH3|THPH4;protein C (inactivator of coagulation factors Va and VIIIa);PROC;protein C (inactivator of coagulation factors Va and VIIIa) |
Definition | anticoagulant protein C|autoprothrombin IIA|blood coagulation factor XIV|prepro-protein C|vitamin K-dependent protein C |
Position | 2q13-q14 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Common Pathway;PID Reactome;500303 |
Pathway | Gamma-carboxylation, transport, and amino-terminal cleavage of proteins;PID Reactome;500540 |
Pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages;PID BioCarta;100152 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | multi-step regulation of transcription by pitx2;PID BioCarta;100074 |
Pathway | Removal of aminoterminal propeptides from gamma-carboxylated proteins;PID Reactome;500543 |
Pathway | Metabolism of proteins;Reactome;REACT:17015 |
Pathway | wnt signaling pathway;PID BioCarta;100002 |
Pathway | Cell surface interactions at the vascular wall;PID Reactome;500305 |
Pathway | intrinsic prothrombin activation pathway;PID BioCarta;100122 |
Pathway | extrinsic prothrombin activation pathway;PID BioCarta;100168 |
Pathway | Complement and coagulation cascades;KEGG PATHWAY;hsa04610 |
Pathway | Blood coagulation;PANTHER;P00011 |
Pathway | tgf beta signaling pathway;PID BioCarta;100017 |
Pathway | Gamma-carboxylation of protein precursors;PID Reactome;500541 |
Pathway | Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;PID Reactome;500542 |
Pathway | segmentation clock;PID BioCarta;100146 |
Disease | Plasma levels of Protein C;NHGRI |
Disease | METABOLIC;GAD |
Disease | Hematologic diseases;KEGG DISEASE |
Disease | warfarin sensitivity;GAD |
Disease | circulating protein C levels and thrombotic risk;GAD |
Disease | Circulatory system diseases;KEGG DISEASE |
Disease | Multiple Organ Failure;GAD |
Disease | Venous Thrombosis;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | PHARMACOGENOMIC;GAD |
Disease | sepsis;GAD |
Disease | plasma protein C levels and thrombotic risk;GAD |
Disease | Thrombophilia due to protein C deficiency, autosomal recessive;OMIM |
Disease | Thrombophilia due to protein C deficiency, autosomal dominant;OMIM |
Disease | Inherited thrombophilia;KEGG DISEASE;H00223 |
Disease | Hereditary protein C deficiency;GAD |
External Links | |
Links to Entrez Gene | 5624 |
Links to all GeneRIF Items | 5624 |
Links to iHOP | 5624 |
Sequence Information | |
Nucleotide Sequence | >5624 : length: 1889 CAAATATTTGTGGTTATGGATTAACTCGAACTCCAGGCTGTCATGGCGGCAGGACGGCGA ACTTGCAGTATCTCCACGACCCGCCCCTGTGCCAGTGCCTCCAGAATGTGGCAGCTCACA AGCCTCCTGCTGTTCGTGGCCACCTGGGGAATTTCCGGCACACCAGCTCCTCTTGACTCA GTGTTCTCCAGCAGCGAGCGTGCCCACCAGGTGCTGCGGATCCGCAAACGTGCCAACTCC TTCCTGGAGGAGCTCCGTCACAGCAGCCTGGAGCGGGAGTGCATAGAGGAGATCTGTGAC TTCGAGGAGGCCAAGGAAATTTTCCAAAATGTGGATGACACACTGGCCTTCTGGTCCAAG CACGTCGACGGTGACCAGTGCTTGGTCTTGCCCTTGGAGCACCCGTGCGCCAGCCTGTGC TGCGGGCACGGCACGTGCATCGACGGCATCGGCAGCTTCAGCTGCGACTGCCGCAGCGGC TGGGAGGGCCGCTTCTGCCAGCGCGGTGAGGGGGAGAGGTGGATGCTGGCGGGCGGCGGG GCGGGGCTGGGGCCGGGTTGGGGGCGCGGCACCAGCACCAGCTGCCCGCGCCCTCCCCTG CCCGCAGAGGTGAGCTTCCTCAATTGCTCGCTGGACAACGGCGGCTGCACGCATTACTGC CTAGAGGAGGTGGGCTGGCGGCGCTGTAGCTGTGCGCCTGGCTACAAGCTGGGGGACGAC CTCCTGCAGTGTCACCCCGCAGTGAAGTTCCCTTGTGGGAGGCCCTGGAAGCGGATGGAG AAGAAGCGCAGTCACCTGAAACGAGACACAGAAGACCAAGAAGACCAAGTAGATCCGCGG CTCATTGATGGGAAGATGACCAGGCGGGGAGACAGCCCCTGGCAGGTGGTCCTGCTGGAC TCAAAGAAGAAGCTGGCCTGCGGGGCAGTGCTCATCCACCCCTCCTGGGTGCTGACAGCG GCCCACTGCATGGATGAGTCCAAGAAGCTCCTTGTCAGGCTTGGAGAGTATGACCTGCGG CGCTGGGAGAAGTGGGAGCTGGACCTGGACATCAAGGAGGTCTTCGTCCACCCCAACTAC AGCAAGAGCACCACCGACAATGACATCGCACTGCTGCACCTGGCCCAGCCCGCCACCCTC TCGCAGACCATAGTGCCCATCTGCCTCCCGGACAGCGGCCTTGCAGAGCGCGAGCTCAAT CAGGCCGGCCAGGAGACCCTCGTGACGGGCTGGGGCTACCACAGCAGCCGAGAGAAGGAG GCCAAGAGAAACCGCACCTTCGTCCTCAACTTCATCAAGATTCCCGTGGTCCCGCACAAT GAGTGCAGCGAGGTCATGAGCAACATGGTGTCTGAGAACATGCTGTGTGCGGGCATCCTC GGGGACCGGCAGGATGCCTGCGAGGGCGACAGTGGGGGGCCCATGGTCGCCTCCTTCCAC GGCACCTGGTTCCTGGTGGGCCTGGTGAGCTGGGGTGAGGGCTGTGGGCTCCTTCACAAC TACGGCGTTTACACCAAAGTCAGCCGCTACCTCGACTGGATCCATGGGCACATCAGAGAC AAGGAAGCCCCCCAGAAGAGCTGGGCACCTTAGCGACCCTCCCTGCAGGGCTGGGCTTTT GCATGGCAATGGATGGGACATTAAAGGGACATGTAACAAGCACACCGGCCTGCTGTTCTG TCCTTCCATCCCTCTTTTGGGCTCTTCTGGAGGGAAGTAACATTTACTGAGCACCTGTTG TATGTCACATGCCTTATGAATAGAATCTTAACTCCTAGAGCAACTCTGTGGGGTGGGGAG GAGCAGATCCAAGTTTTGCGGGGTCTAAAGCTGTGTGTGTTGAGGGGGATACTCTGTTTA TGAAAAAGAATAAAAAACACAACCACGAA |
Protein Sequence | >5624 : length: 522 MAAGRRTCSISTTRPSSALTASTQGQPFHSASTWGCRQSSSGGRHCPELRSPPQTGASAS RMWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLEREC IEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFS CDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAV KFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACG AVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDND IALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFV LNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGL VSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP |