Entrez Gene

Basic Information
Gene ID	5305
Name	PIP4K2A
Synonymous	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha;PIP4K2A;phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Definition	1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha\|1-phosphatidylinositol-4-phosphate kinase\|1-phosphatidylinositol-4-phosphate-5-kinase\|1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha\|PI(5)P 4-kinase type II alpha\|PIP4KII-alpha\|PIP5KIII\|PIP5KIIalpha
Position	10p12.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.534C>A; p.F178L; 10:22573416-22573416	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.133_134insG; p.V45fs*7; 10:22714193-22714194	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.565G>T; p.V189F; 10:22573385-22573385	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.117C>A; p.S39R; 10:22714210-22714210	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.453C>T; p.D151D; 10:22591668-22591668	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1053G>T; p.E351D; 10:22540058-22540058	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1200T>A; p.F400L; 10:22537222-22537222	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.166C>A; p.Q56K; 10:22609696-22609696	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.973C>T; p.P325S; 10:22541867-22541867	skin	malignant_melanoma	Substitution - Missense
c.973C>T; p.P325S; 10:22541867-22541867	skin	malignant_melanoma	Substitution - Missense
c.229C>A; p.H77N; 10:22609633-22609633	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.624G>A; p.R208R; 10:22573326-22573326	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.64C>T; p.H22Y; 10:22714263-22714263	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.640G>T; p.G214C; 10:22567889-22567889	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.397C>T; p.R133C; 10:22591724-22591724	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.397C>T; p.R133C; 10:22591724-22591724	skin	malignant_melanoma	Substitution - Missense
c.941_942insC; p.D315fs*2; 10:22541898-22541899	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.929T>G; p.V310G; 10:22541911-22541911	breast	carcinoma	Substitution - Missense
c.362C>A; p.P121H; 10:22591759-22591759	breast	carcinoma	Substitution - Missense
c.304C>T; p.R102W; 10:22607962-22607962	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.799G>A; p.A267T; 10:22542041-22542041	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1120G>T; p.A374S; 10:22539991-22539991	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.641G>A; p.G214D; 10:22567888-22567888	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.938C>T; p.P313L; 10:22541902-22541902	skin	malignant_melanoma	Substitution - Missense
c.429C>T; p.I143I; 10:22591692-22591692	liver	carcinoma	Substitution - coding silent
c.429C>T; p.I143I; 10:22591692-22591692	liver	carcinoma	Substitution - coding silent
c.121C>T; p.L41F; 10:22714206-22714206	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.941delC; p.P314fs*8; 10:22541899-22541899	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.941delC; p.P314fs*8; 10:22541899-22541899	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.941delC; p.P314fs*8; 10:22541899-22541899	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.941delC; p.P314fs*8; 10:22541899-22541899	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.296G>A; p.R99H; 10:22607970-22607970	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.296G>A; p.R99H; 10:22607970-22607970	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1141-1G>A; p.?; 10:22537282-22537282	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.381G>T; p.Q127H; 10:22591740-22591740	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.386G>A; p.R129H; 10:22591735-22591735	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.487C>T; p.H163Y; 10:22591634-22591634	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.487C>T; p.H163Y; 10:22591634-22591634	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.854G>C; p.R285T; 10:22541986-22541986	urinary_tract; bladder	carcinoma	Substitution - Missense
c.752A>G; p.N251S; 10:22550699-22550699	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.752A>G; p.N251S; 10:22550699-22550699	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.752A>G; p.N251S; 10:22550699-22550699	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.285G>A; p.P95P; 10:22607981-22607981	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.897G>A; p.E299E; 10:22541943-22541943	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.75G>A; p.A25A; 10:22714252-22714252	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.961C>T; p.L321L; 10:22541879-22541879	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.488A>C; p.H163P; 10:22591633-22591633	ovary	other; neoplasm	Substitution - Missense
c.718A>T; p.N240Y; 10:22550733-22550733	liver	carcinoma	Substitution - Missense
c.792G>T; p.E264D; 10:22550659-22550659	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.151G>A; p.E51K; 10:22609711-22609711	skin	malignant_melanoma	Substitution - Missense
c.151G>A; p.E51K; 10:22609711-22609711	skin	malignant_melanoma	Substitution - Missense
c.996C>T; p.F332F; 10:22541844-22541844	breast	carcinoma	Substitution - coding silent
c.996C>T; p.F332F; 10:22541844-22541844	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.996C>T; p.F332F; 10:22541844-22541844	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.626A>G; p.K209R; 10:22573324-22573324	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.474C>G; p.I158M; 10:22591647-22591647	ovary	other; neoplasm	Substitution - Missense
c.474C>G; p.I158M; 10:22591647-22591647	ovary	other; neoplasm	Substitution - Missense
c.1001C>T; p.P334L; 10:22541839-22541839	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.13G>A; p.G5S; 10:22714314-22714314	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1045A>G; p.R349G; 10:22540066-22540066	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1014C>G; p.V338V; 10:22541826-22541826	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.762C>T; p.V254V; 10:22550689-22550689	skin	malignant_melanoma	Substitution - coding silent
c.672A>C; p.K224N; 10:22567857-22567857	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.223G>A; p.D75N; 10:22609639-22609639	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.259C>T; p.H87Y; 10:22608007-22608007	skin	malignant_melanoma	Substitution - Missense
c.949C>G; p.P317A; 10:22541891-22541891	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.61A>G; p.K21E; 10:22714266-22714266	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.398G>A; p.R133H; 10:22591723-22591723	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.398G>A; p.R133H; 10:22591723-22591723	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.398G>A; p.R133H; 10:22591723-22591723	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.398G>A; p.R133H; 10:22591723-22591723	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.398G>A; p.R133H; 10:22591723-22591723	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.398G>A; p.R133H; 10:22591723-22591723	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.398G>A; p.R133H; 10:22591723-22591723	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.398G>A; p.R133H; 10:22591723-22591723	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.440T>C; p.I147T; 10:22591681-22591681	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.398G>A; p.R133H; 10:22591723-22591723	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.398G>A; p.R133H; 10:22591723-22591723	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.398G>A; p.R133H; 10:22591723-22591723	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.398G>A; p.R133H; 10:22591723-22591723	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.817G>A; p.D273N; 10:22542023-22542023	skin	malignant_melanoma	Substitution - Missense
c.1084A>G; p.T362A; 10:22540027-22540027	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.416A>G; p.D139G; 10:22591705-22591705	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1202T>A; p.I401N; 10:22537220-22537220	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1009G>A; p.D337N; 10:22541831-22541831	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.372C>T; p.N124N; 10:22591749-22591749	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.5C>T; p.A2V; 10:22714322-22714322	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.534C>T; p.F178F; 10:22573416-22573416	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.354G>A; p.R118R; 10:22591767-22591767	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.171C>T; p.I57I; 10:22609691-22609691	skin	malignant_melanoma	Substitution - coding silent
c.770A>G; p.E257G; 10:22550681-22550681	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.376T>A; p.S126T; 10:22591745-22591745	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.69C>T; p.F23F; 10:22714258-22714258	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1140C>T; p.G380G; 10:22539971-22539971	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.790G>T; p.E264*; 10:22550661-22550661	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.953G>T; p.G318V; 10:22541887-22541887	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.51G>C; p.K17N; 10:22714276-22714276	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1026G>T; p.K342N; 10:22541814-22541814	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1058A>T; p.Y353F; 10:22540053-22540053	urinary_tract; bladder	carcinoma	Substitution - Missense
c.454G>T; p.V152L; 10:22591667-22591667	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.385C>T; p.R129C; 10:22591736-22591736	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]