Entrez Gene

Basic Information
Gene ID	405
Name	ARNT
Synonymous	aryl hydrocarbon receptor nuclear translocator;ARNT;aryl hydrocarbon receptor nuclear translocator
Definition	class E basic helix-loop-helix protein 2\|dioxin receptor, nuclear translocator\|hypoxia-inducible factor 1, beta subunit
Position	1q21
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.121A>G; p.I41V; 1:150858365-150858365	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2034C>T; p.S678S; 1:150814156-150814156	liver	carcinoma	Substitution - coding silent
c.121A>G; p.I41V; 1:150858365-150858365	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.620G>A; p.S207N; 1:150836360-150836360	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1877C>T; p.S626F; 1:150816332-150816332	skin	malignant_melanoma	Substitution - Missense
c.1040G>A; p.S347N; 1:150829220-150829220	skin	malignant_melanoma	Substitution - Missense
c.1561A>G; p.S521G; 1:150817378-150817378	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.909C>T; p.F303F; 1:150831864-150831864	skin	malignant_melanoma	Substitution - coding silent
c.867C>T; p.C289C; 1:150832336-150832336	pancreas	carcinoma	Substitution - coding silent
c.1856G>A; p.G619E; 1:150816353-150816353	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1387A>G; p.N463D; 1:150823201-150823201	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2353C>T; p.P785S; 1:150812038-150812038	oesophagus	carcinoma	Substitution - Missense
c.2353C>T; p.P785S; 1:150812038-150812038	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2353C>T; p.P785S; 1:150812038-150812038	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1658G>T; p.R553I; 1:150817123-150817123	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1524A>C; p.T508T; 1:150817415-150817415	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.424T>A; p.L142M; 1:150839503-150839503	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2335C>T; p.P779S; 1:150812056-150812056	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1783C>T; p.R595W; 1:150816807-150816807	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2338G>C; p.D780H; 1:150812053-150812053	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.638T>A; p.V213E; 1:150836342-150836342	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.292G>C; p.E98Q; 1:150839635-150839635	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.217C>T; p.R73W; 1:150846273-150846273	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1700-1G>A; p.?; 1:150816891-150816891	large_intestine; rectum	carcinoma; adenocarcinoma	Unknown
c.739G>T; p.E247*; 1:150834602-150834602	breast	carcinoma	Substitution - Nonsense
c.180G>T; p.L60F; 1:150852764-150852764	pancreas	carcinoma	Substitution - Missense
c.180G>T; p.L60F; 1:150852764-150852764	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1354G>A; p.D452N; 1:150823234-150823234	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.919C>T; p.H307Y; 1:150831854-150831854	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1749A>G; p.L583L; 1:150816841-150816841	liver	carcinoma	Substitution - coding silent
c.1749A>G; p.L583L; 1:150816841-150816841	liver	carcinoma	Substitution - coding silent
c.1106T>C; p.I369T; 1:150829154-150829154	breast	carcinoma	Substitution - Missense
c.1844C>G; p.S615*; 1:150816365-150816365	pancreas	carcinoma; acinar_carcinoma	Substitution - Nonsense
c.1257A>C; p.K419N; 1:150823331-150823331	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1395-1G>T; p.?; 1:150818031-150818031	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.767G>A; p.C256Y; 1:150834574-150834574	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1250A>G; p.K417R; 1:150823338-150823338	urinary_tract; bladder	carcinoma	Substitution - Missense
c.331G>T; p.E111*; 1:150839596-150839596	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1482G>C; p.M494I; 1:150817943-150817943	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.1292C>G; p.S431C; 1:150823296-150823296	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1845A>G; p.S615S; 1:150816364-150816364	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.304C>T; p.R102W; 1:150839623-150839623	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.470C>T; p.S157F; 1:150839457-150839457	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.301C>T; p.R101*; 1:150839626-150839626	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1803G>A; p.R601R; 1:150816406-150816406	skin	malignant_melanoma	Substitution - coding silent
c.2113+1G>A; p.?; 1:150814076-150814076	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.936C>T; p.I312I; 1:150831837-150831837	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1157A>C; p.Y386S; 1:150829103-150829103	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.990C>T; p.G330G; 1:150829946-150829946	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.312G>C; p.K104N; 1:150839615-150839615	urinary_tract; bladder	carcinoma	Substitution - Missense
c.278A>G; p.N93S; 1:150839649-150839649	skin	malignant_melanoma	Substitution - Missense
c.1326C>T; p.S442S; 1:150823262-150823262	skin	malignant_melanoma	Substitution - coding silent
c.474C>T; p.F158F; 1:150839453-150839453	skin	malignant_melanoma	Substitution - coding silent
c.280C>T; p.H94Y; 1:150839647-150839647	skin	malignant_melanoma	Substitution - Missense
c.280C>T; p.H94Y; 1:150839647-150839647	skin	malignant_melanoma	Substitution - Missense
c.1836C>T; p.V612V; 1:150816373-150816373	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.218G>T; p.R73L; 1:150846272-150846272	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.712G>A; p.D238N; 1:150834629-150834629	skin; arm	malignant_melanoma	Substitution - Missense
c.1175T>C; p.L392S; 1:150826610-150826610	breast	carcinoma	Substitution - Missense
c.1095C>T; p.S365S; 1:150829165-150829165	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.1095C>T; p.S365S; 1:150829165-150829165	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.797G>A; p.R266Q; 1:150834544-150834544	oesophagus	carcinoma	Substitution - Missense
c.1985C>A; p.T662N; 1:150814205-150814205	breast	carcinoma	Substitution - Missense
c.2114-3T>G; p.?; 1:150813341-150813341	liver	carcinoma	Unknown
c.2114-3T>G; p.?; 1:150813341-150813341	liver	carcinoma	Unknown
c.744T>C; p.G248G; 1:150834597-150834597	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.1575C>T; p.S525S; 1:150817364-150817364	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.414C>T; p.H138H; 1:150839513-150839513	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.665G>C; p.R222P; 1:150836315-150836315	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.374A>G; p.K125R; 1:150839553-150839553	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1900G>A; p.G634R; 1:150816309-150816309	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.374A>G; p.K125R; 1:150839553-150839553	stomach	adenocarcinoma	Substitution - Missense
c.2105C>A; p.S702Y; 1:150814085-150814085	kidney	other; neoplasm	Substitution - Missense
c.2105C>A; p.S702Y; 1:150814085-150814085	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2101G>T; p.G701*; 1:150814089-150814089	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1175_1176insG; p.G393fs*11; 1:150826609-150826610	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Insertion - Frameshift
c.2168T>A; p.V723E; 1:150813284-150813284	liver	carcinoma	Substitution - Missense
c.1821T>C; p.P607P; 1:150816388-150816388	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.737A>G; p.K246R; 1:150834604-150834604	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1820C>T; p.P607L; 1:150816389-150816389	skin	malignant_melanoma	Substitution - Missense
c.169A>T; p.S57C; 1:150852775-150852775	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.711G>A; p.L237L; 1:150834630-150834630	skin; arm	malignant_melanoma	Substitution - coding silent
c.91C>T; p.Q31*; 1:150858395-150858395	skin	malignant_melanoma	Substitution - Nonsense
c.567G>C; p.V189V; 1:150836413-150836413	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1281C>T; p.F427F; 1:150823307-150823307	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.567G>C; p.V189V; 1:150836413-150836413	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.567G>C; p.V189V; 1:150836413-150836413	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.567G>C; p.V189V; 1:150836413-150836413	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1645T>A; p.F549I; 1:150817136-150817136	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.384G>A; p.K128K; 1:150839543-150839543	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1834G>A; p.V612I; 1:150816375-150816375	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.962C>T; p.S321F; 1:150829974-150829974	skin	malignant_melanoma	Substitution - Missense
c.962C>T; p.S321F; 1:150829974-150829974	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1836C>G; p.V612V; 1:150816373-150816373	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.557T>G; p.V186G; 1:150836423-150836423	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1836C>G; p.V612V; 1:150816373-150816373	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1287C>T; p.F429F; 1:150823301-150823301	skin	malignant_melanoma	Substitution - coding silent
c.2358delC; p.S788fs*>2; 1:150812033-150812033	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1562G>C; p.S521T; 1:150817377-150817377	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.796C>T; p.R266*; 1:150834545-150834545	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2064G>A; p.S688S; 1:150814126-150814126	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1396A>C; p.N466H; 1:150818029-150818029	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1981C>T; p.R661C; 1:150814209-150814209	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1458C>T; p.P486P; 1:150817967-150817967	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1594A>G; p.T532A; 1:150817187-150817187	oesophagus	carcinoma	Substitution - Missense
c.2045C>G; p.P682R; 1:150814145-150814145	thyroid	carcinoma; medullary_carcinoma	Substitution - Missense
c.268G>A; p.A90T; 1:150842428-150842428	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1663C>T; p.P555S; 1:150817118-150817118	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.1642T>G; p.L548V; 1:150817139-150817139	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1648G>T; p.A550S; 1:150817133-150817133	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.697A>G; p.T233A; 1:150836283-150836283	prostate	carcinoma	Substitution - Missense
c.295C>T; p.R99W; 1:150839632-150839632	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1385C>T; p.T462I; 1:150823203-150823203	skin	malignant_melanoma	Substitution - Missense
c.1518G>A; p.Q506Q; 1:150817421-150817421	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.966C>T; p.L322L; 1:150829970-150829970	skin	malignant_melanoma	Substitution - coding silent
c.555G>A; p.R185R; 1:150836425-150836425	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.966C>T; p.L322L; 1:150829970-150829970	skin	malignant_melanoma	Substitution - coding silent
c.966C>T; p.L322L; 1:150829970-150829970	skin	malignant_melanoma	Substitution - coding silent
c.2280+6A>T; p.?; 1:150813166-150813166	kidney	other; neoplasm	Unknown
c.854T>G; p.V285G; 1:150832349-150832349	skin	malignant_melanoma	Substitution - Missense
c.894T>C; p.D298D; 1:150831879-150831879	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.894T>C; p.D298D; 1:150831879-150831879	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1094C>A; p.S365Y; 1:150829166-150829166	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2241A>C; p.Q747H; 1:150813211-150813211	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1783_1784insC; p.R595fs*9; 1:150816806-150816807	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1162C>T; p.P388S; 1:150829098-150829098	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.955+1G>A; p.?; 1:150831817-150831817	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.100G>C; p.G34R; 1:150858386-150858386	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2329G>T; p.E777*; 1:150812062-150812062	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1780C>T; p.P594S; 1:150816810-150816810	skin	malignant_melanoma	Substitution - Missense
c.1999G>A; p.V667M; 1:150814191-150814191	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1567A>C; p.N523H; 1:150817372-150817372	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2222G>A; p.S741N; 1:150813230-150813230	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2021C>T; p.S674F; 1:150814169-150814169	kidney	other; neoplasm	Substitution - Missense
c.485A>C; p.Q162P; 1:150839442-150839442	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1244T>C; p.V415A; 1:150823344-150823344	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1644A>G; p.L548L; 1:150817137-150817137	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]