Cancer metastasis gene database Home
Cancer metastasis database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

3827

Name

KNG1

Synonymous

kininogen 1;KNG1;kininogen 1

Definition

HMWK|alpha-2-thiol proteinase inhibitor|bradykinin|fitzgerald factor|high molecular weight kininogen|kininogen-1|williams-Fitzgerald-Flaujeac factor

Position

3q27

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.801C>T; p.C267C; 3:186732545-186732545

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.801C>T; p.C267C; 3:186732545-186732545

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.599C>T; p.S200L; 3:186727271-186727271

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.801C>T; p.C267C; 3:186732545-186732545

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.579G>T; p.L193F; 3:186727251-186727251

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1126-1G>A; p.?; 3:186741521-186741521

 skin; head_neckcarcinoma; squamous_cell_carcinomaUnknown

c.241G>T; p.G81W; 3:186720150-186720150

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1165C>T; p.R389*; 3:186741561-186741561

 pleurapulmonary_blastomaSubstitution - Nonsense

c.39G>C; p.L13L; 3:186717581-186717581

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.254delT; p.Q86fs*51; 3:186720163-186720163

 soft_tissue; blood_vesselangiosarcomaDeletion - Frameshift

c.73G>A; p.E25K; 3:186717615-186717615

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.574G>T; p.G192*; 3:186727246-186727246

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.58G>A; p.E20K; 3:186717600-186717600

 skinmalignant_melanomaSubstitution - Missense

c.627G>A; p.E209E; 3:186727299-186727299

 skinmalignant_melanomaSubstitution - coding silent

c.1042A>G; p.S348G; 3:186739331-186739331

 livercarcinomaSubstitution - Missense

c.1042A>G; p.S348G; 3:186739331-186739331

 livercarcinomaSubstitution - Missense

c.246T>C; p.D82D; 3:186720155-186720155

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.196-4T>C; p.?; 3:186720101-186720101

 lungcarcinoma; squamous_cell_carcinomaUnknown

c.945G>T; p.K315N; 3:186739113-186739113

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.368C>A; p.T123N; 3:186722498-186722498

 prostateadenomaSubstitution - Missense

c.591T>G; p.I197M; 3:186727263-186727263

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.591T>G; p.I197M; 3:186727263-186727263

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.591T>G; p.I197M; 3:186727263-186727263

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.107C>A; p.A36D; 3:186717649-186717649

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.94G>T; p.D32Y; 3:186717636-186717636

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.1025delC; p.K344fs*6; 3:186739193-186739193

 lungcarcinoma; adenocarcinomaDeletion - Frameshift

c.1252G>A; p.A418T; 3:186743753-186743753

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.561A>G; p.R187R; 3:186725257-186725257

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1253delC; p.A418fs*>10; 3:186743754-186743754

 skin; head_neckcarcinoma; squamous_cell_carcinomaDeletion - Frameshift

c.48T>C; p.S16S; 3:186717590-186717590

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.229G>T; p.E77*; 3:186720138-186720138

 prostatecarcinomaSubstitution - Nonsense

c.461C>T; p.P154L; 3:186725157-186725157

 pancreascarcinomaSubstitution - Missense

c.461C>T; p.P154L; 3:186725157-186725157

 pancreascarcinomaSubstitution - Missense

c.594C>T; p.T198T; 3:186727266-186727266

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.291G>A; p.K97K; 3:186720200-186720200

 skinmalignant_melanomaSubstitution - coding silent

c.1269G>C; p.E423D; 3:186743770-186743770

 skin; scalpcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.706G>A; p.D236N; 3:186731578-186731578

 skinmalignant_melanomaSubstitution - Missense

c.105A>C; p.K35N; 3:186717647-186717647

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.350C>A; p.T117K; 3:186722480-186722480

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.630T>G; p.N210K; 3:186727302-186727302

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.173G>T; p.R58L; 3:186717715-186717715

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.908A>T; p.N303I; 3:186732652-186732652

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.394G>A; p.E132K; 3:186725090-186725090

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.335G>A; p.G112E; 3:186722465-186722465

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1231G>T; p.G411C; 3:186743732-186743732

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.941G>T; p.G314V; 3:186739109-186739109

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.336G>A; p.G112G; 3:186722466-186722466

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.359_360CC>GG; p.S120W; 3:186722489-186722490

 biliary_tract; gallbladdercarcinoma; adenocarcinomaSubstitution - Missense

c.824G>A; p.S275N; 3:186732568-186732568

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.824G>A; p.S275N; 3:186732568-186732568

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.923G>C; p.R308T; 3:186732667-186732667

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.106G>A; p.A36T; 3:186717648-186717648

 skinmalignant_melanomaSubstitution - Missense

c.133A>G; p.N45D; 3:186717675-186717675

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.565G>T; p.V189L; 3:186727237-186727237

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.288C>A; p.Y96*; 3:186720197-186720197

 lungcarcinoma; small_cell_carcinomaSubstitution - Nonsense

c.976A>G; p.T326A; 3:186739144-186739144

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.158A>G; p.Q53R; 3:186717700-186717700

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1183G>A; p.E395K; 3:186741579-186741579

 skinmalignant_melanomaSubstitution - Missense

c.442C>T; p.P148S; 3:186725138-186725138

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.458G>A; p.S153N; 3:186725154-186725154

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.173G>A; p.R58H; 3:186717715-186717715

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.840G>A; p.E280E; 3:186732584-186732584

 skin; shouldermalignant_melanomaSubstitution - coding silent

c.900G>C; p.K300N; 3:186732644-186732644

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.900G>C; p.K300N; 3:186732644-186732644

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.952T>G; p.F318V; 3:186739120-186739120

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.791G>T; p.C264F; 3:186732535-186732535

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.795G>A; p.V265V; 3:186732539-186732539

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.982T>C; p.C328R; 3:186739150-186739150

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1048G>A; p.D350N; 3:186739337-186739337

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1175G>A; p.R392Q; 3:186741571-186741571

 skinmalignant_melanomaSubstitution - Missense

c.1175G>A; p.R392Q; 3:186741571-186741571

 skinmalignant_melanomaSubstitution - Missense

c.902T>C; p.I301T; 3:186732646-186732646

 breastcarcinomaSubstitution - Missense

c.728C>T; p.S243F; 3:186731600-186731600

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.665G>A; p.W222*; 3:186727337-186727337

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.39G>A; p.L13L; 3:186717581-186717581

 prostateadenomaSubstitution - coding silent

c.39G>A; p.L13L; 3:186717581-186717581

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.39G>A; p.L13L; 3:186717581-186717581

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.1021G>C; p.E341Q; 3:186739189-186739189

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.930G>A; p.Q310Q; 3:186732674-186732674

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.614A>C; p.N205T; 3:186727286-186727286

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.419A>G; p.Y140C; 3:186725115-186725115

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.612G>A; p.T204T; 3:186727284-186727284

 skinmalignant_melanomaSubstitution - coding silent

c.612G>A; p.T204T; 3:186727284-186727284

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.612G>A; p.T204T; 3:186727284-186727284

 skinmalignant_melanomaSubstitution - coding silent

c.904G>T; p.D302Y; 3:186732648-186732648

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1114C>T; p.P372S; 3:186739403-186739403

 breastcarcinomaSubstitution - Missense

c.533T>C; p.M178T; 3:186725229-186725229

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.627G>T; p.E209D; 3:186727299-186727299

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.533T>C; p.M178T; 3:186725229-186725229

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1203+7C>T; p.?; 3:186741606-186741606

 skin; head_neckcarcinoma; squamous_cell_carcinomaUnknown

c.1255G>A; p.E419K; 3:186743756-186743756

 skinmalignant_melanomaSubstitution - Missense

c.1095C>T; p.Y365Y; 3:186739384-186739384

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1272G>T; p.R424S; 3:186743773-186743773

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1272G>T; p.R424S; 3:186743773-186743773

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - Missense

c.1039-1G>A; p.?; 3:186739327-186739327

 central_nervous_system; brainglioma; astrocytoma_Grade_IVUnknown

c.1039-1G>A; p.?; 3:186739327-186739327

 central_nervous_system; brainglioma; astrocytoma_Grade_IVUnknown

c.719G>A; p.R240Q; 3:186731591-186731591

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.239A>T; p.E80V; 3:186720148-186720148

 skinmalignant_melanomaSubstitution - Missense

c.372G>T; p.Q124H; 3:186722502-186722502

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.719G>A; p.R240Q; 3:186731591-186731591

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.719G>A; p.R240Q; 3:186731591-186731591

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.844C>A; p.L282M; 3:186732588-186732588

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.329C>T; p.T110I; 3:186722459-186722459

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.844C>A; p.L282M; 3:186732588-186732588

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.920C>A; p.A307E; 3:186732664-186732664

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.159G>C; p.Q53H; 3:186717701-186717701

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense