Entrez Gene

Basic Information
Gene ID	3236
Name	HOXD10
Synonymous	homeobox D10;HOXD10;homeobox D10
Definition	homeo box 4D\|homeo box D10\|homeobox protein Hox-4D\|homeobox protein Hox-4E\|homeobox protein Hox-D10
Position	2q31.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.432T>C; p.P144P; 2:176117265-176117265	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.249T>C; p.D83D; 2:176117082-176117082	pancreas	carcinoma	Substitution - coding silent
c.160C>A; p.L54I; 2:176116993-176116993	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.133A>T; p.T45S; 2:176116966-176116966	skin	malignant_melanoma	Substitution - Missense
c.62C>T; p.A21V; 2:176116895-176116895	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.424G>A; p.E142K; 2:176117257-176117257	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.62C>T; p.A21V; 2:176116895-176116895	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.641C>T; p.S214F; 2:176117474-176117474	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.315C>A; p.T105T; 2:176117148-176117148	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.104A>G; p.Y35C; 2:176116937-176116937	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.679G>A; p.E227K; 2:176117512-176117512	breast	carcinoma	Substitution - Missense
c.395A>T; p.Q132L; 2:176117228-176117228	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.87C>T; p.S29S; 2:176116920-176116920	breast	carcinoma	Substitution - coding silent
c.374C>T; p.S125L; 2:176117207-176117207	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.374C>T; p.S125L; 2:176117207-176117207	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.374C>T; p.S125L; 2:176117207-176117207	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.378C>T; p.A126A; 2:176117211-176117211	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.623A>T; p.Q208L; 2:176117456-176117456	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.30T>C; p.A10A; 2:176116863-176116863	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.658G>A; p.E220K; 2:176117491-176117491	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.358C>T; p.R120C; 2:176117191-176117191	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.138T>A; p.Y46*; 2:176116971-176116971	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.491A>C; p.Q164P; 2:176117324-176117324	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.138T>A; p.Y46*; 2:176116971-176116971	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.393C>T; p.Y131Y; 2:176117226-176117226	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.296C>T; p.P99L; 2:176117129-176117129	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.552C>T; p.G184G; 2:176117385-176117385	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.419C>T; p.P140L; 2:176117252-176117252	skin	malignant_melanoma	Substitution - Missense
c.600G>T; p.K200N; 2:176117433-176117433	skin	malignant_melanoma	Substitution - Missense
c.653G>T; p.S218I; 2:176117486-176117486	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.815C>T; p.P272L; 2:176119023-176119023	skin	malignant_melanoma	Substitution - Missense
c.397A>C; p.R133R; 2:176117230-176117230	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.815C>T; p.P272L; 2:176119023-176119023	skin	malignant_melanoma	Substitution - Missense
c.86C>A; p.S29Y; 2:176116919-176116919	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.697G>A; p.A233T; 2:176117530-176117530	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.550G>A; p.G184S; 2:176117383-176117383	skin	malignant_melanoma	Substitution - Missense
c.697G>A; p.A233T; 2:176117530-176117530	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.350C>A; p.S117Y; 2:176117183-176117183	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.445C>T; p.P149S; 2:176117278-176117278	skin	malignant_melanoma	Substitution - Missense
c.795T>C; p.S265S; 2:176119003-176119003	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.266G>C; p.R89P; 2:176117099-176117099	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.442G>A; p.V148I; 2:176117275-176117275	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.613G>A; p.V205M; 2:176117446-176117446	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.856T>A; p.L286M; 2:176119064-176119064	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.547C>T; p.R183C; 2:176117380-176117380	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.547C>T; p.R183C; 2:176117380-176117380	skin	malignant_melanoma	Substitution - Missense
c.179G>T; p.R60I; 2:176117012-176117012	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.826C>T; p.H276Y; 2:176119034-176119034	liver	carcinoma	Substitution - Missense
c.124G>T; p.D42Y; 2:176116957-176116957	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.165G>A; p.P55P; 2:176116998-176116998	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.165G>A; p.P55P; 2:176116998-176116998	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.165G>A; p.P55P; 2:176116998-176116998	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.165G>A; p.P55P; 2:176116998-176116998	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.165G>A; p.P55P; 2:176116998-176116998	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.362A>T; p.N121I; 2:176117195-176117195	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.154G>T; p.G52*; 2:176116987-176116987	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.390G>A; p.S130S; 2:176117223-176117223	pancreas	carcinoma	Substitution - coding silent
c.892G>T; p.E298*; 2:176119100-176119100	parathyroid	carcinoma	Substitution - Nonsense
c.36delT; p.L14fs*1; 2:176116869-176116869	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.625G>A; p.E209K; 2:176117458-176117458	skin	malignant_melanoma	Substitution - Missense
c.252G>A; p.P84P; 2:176117085-176117085	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.727C>T; p.Q243*; 2:176117560-176117560	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Nonsense
c.658G>C; p.E220Q; 2:176117491-176117491	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.333C>G; p.S111S; 2:176117166-176117166	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.902A>C; p.K301T; 2:176119110-176119110	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.879C>T; p.R293R; 2:176119087-176119087	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.750A>G; p.E250E; 2:176118958-176118958	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.750A>G; p.E250E; 2:176118958-176118958	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.400C>T; p.L134L; 2:176117233-176117233	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1015T>C; p.F339L; 2:176119223-176119223	skin	malignant_melanoma	Substitution - Missense
c.218C>T; p.P73L; 2:176117051-176117051	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.218C>T; p.P73L; 2:176117051-176117051	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.549T>C; p.R183R; 2:176117382-176117382	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.709G>A; p.V237M; 2:176117542-176117542	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.139G>T; p.G47*; 2:176116972-176116972	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.87C>G; p.S29S; 2:176116920-176116920	pancreas	carcinoma	Substitution - coding silent
c.163C>A; p.P55T; 2:176116996-176116996	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.657C>A; p.P219P; 2:176117490-176117490	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.637G>A; p.V213I; 2:176117470-176117470	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1020T>G; p.S340S; 2:176119228-176119228	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.748G>T; p.E250*; 2:176118956-176118956	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.612C>T; p.P204P; 2:176117445-176117445	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.747G>A; p.E249E; 2:176118955-176118955	skin	malignant_melanoma	Substitution - coding silent
c.907G>A; p.V303I; 2:176119115-176119115	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.266G>A; p.R89Q; 2:176117099-176117099	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.266G>A; p.R89Q; 2:176117099-176117099	skin	malignant_melanoma	Substitution - Missense
c.896T>C; p.I299T; 2:176119104-176119104	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.994G>A; p.E332K; 2:176119202-176119202	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.648G>A; p.V216V; 2:176117481-176117481	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.983A>G; p.N328S; 2:176119191-176119191	skin	malignant_melanoma	Substitution - Missense
c.619G>T; p.G207C; 2:176117452-176117452	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.923G>A; p.R308K; 2:176119131-176119131	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.474C>T; p.Y158Y; 2:176117307-176117307	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.474C>T; p.Y158Y; 2:176117307-176117307	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.938G>C; p.W313S; 2:176119146-176119146	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.139G>A; p.G47R; 2:176116972-176116972	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.928G>T; p.V310F; 2:176119136-176119136	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.928G>T; p.V310F; 2:176119136-176119136	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.452A>G; p.Y151C; 2:176117285-176117285	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.514G>T; p.G172C; 2:176117347-176117347	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.406C>T; p.P136S; 2:176117239-176117239	skin	malignant_melanoma	Substitution - Missense
c.406C>T; p.P136S; 2:176117239-176117239	skin	malignant_melanoma	Substitution - Missense
c.406C>T; p.P136S; 2:176117239-176117239	skin	malignant_melanoma	Substitution - Missense
c.551G>T; p.G184V; 2:176117384-176117384	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.480C>T; p.T160T; 2:176117313-176117313	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.462G>A; p.L154L; 2:176117295-176117295	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.749A>G; p.E250G; 2:176118957-176118957	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.748G>A; p.E250K; 2:176118956-176118956	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.749A>G; p.E250G; 2:176118957-176118957	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.749A>G; p.E250G; 2:176118957-176118957	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.748G>A; p.E250K; 2:176118956-176118956	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1005C>A; p.A335A; 2:176119213-176119213	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.836T>C; p.L279P; 2:176119044-176119044	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.682G>C; p.E228Q; 2:176117515-176117515	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.719C>A; p.P240H; 2:176117552-176117552	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.133A>G; p.T45A; 2:176116966-176116966	stomach	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]