Entrez Gene

Basic Information
Gene ID	3190
Name	HNRNPK
Synonymous	heterogeneous nuclear ribonucleoprotein K;HNRNPK;heterogeneous nuclear ribonucleoprotein K
Definition	dC-stretch binding protein\|transformation upregulated nuclear protein
Position	9q21.32-q21.33
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.773G>C; p.R258T; 9:83972062-83972062	urinary_tract; bladder	carcinoma	Substitution - Missense
c.892G>A; p.G298S; 9:83971943-83971943	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1163T>C; p.I388T; 9:83970765-83970765	liver	carcinoma	Substitution - Missense
c.354T>G; p.T118T; 9:83973950-83973950	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.205C>T; p.R69C; 9:83977003-83977003	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1213A>T; p.K405*; 9:83970310-83970310	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Nonsense
c.662G>A; p.R221H; 9:83972173-83972173	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1263C>A; p.I421I; 9:83970260-83970260	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.368T>C; p.L123P; 9:83973936-83973936	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.915G>T; p.R305R; 9:83971920-83971920	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.586G>A; p.G196R; 9:83972903-83972903	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.512G>A; p.R171Q; 9:83973290-83973290	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.207T>C; p.R69R; 9:83977001-83977001	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.512G>A; p.R171Q; 9:83973290-83973290	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.213+1_213+2insA; p.?; 9:83976993-83976994	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.631G>C; p.D211H; 9:83972858-83972858	pancreas	carcinoma	Substitution - Missense
c.198G>C; p.K66N; 9:83977010-83977010	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.445C>A; p.L149M; 9:83973357-83973357	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.534C>G; p.I178M; 9:83972955-83972955	urinary_tract; bladder	carcinoma	Substitution - Missense
c.189G>A; p.K63K; 9:83977019-83977019	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.942_944delACC; p.P315delP; 9:83971891-83971893	large_intestine	carcinoma; adenocarcinoma	Deletion - In frame
c.651C>A; p.P217P; 9:83972184-83972184	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1371G>A; p.Q457Q; 9:83969431-83969431	liver	carcinoma	Substitution - coding silent
c.1371G>A; p.Q457Q; 9:83969431-83969431	liver	carcinoma	Substitution - coding silent
c.972C>T; p.D324D; 9:83971708-83971708	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.742G>A; p.G248R; 9:83972093-83972093	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.913C>T; p.R305W; 9:83971922-83971922	skin	malignant_melanoma	Substitution - Missense
c.369C>T; p.L123L; 9:83973935-83973935	skin	malignant_melanoma	Substitution - coding silent
c.913C>T; p.R305W; 9:83971922-83971922	skin	malignant_melanoma	Substitution - Missense
c.351C>T; p.P117P; 9:83973953-83973953	liver	carcinoma	Substitution - coding silent
c.1297C>T; p.R433W; 9:83970226-83970226	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.256C>T; p.R86C; 9:83975463-83975463	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1102G>A; p.G368R; 9:83970903-83970903	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.253G>A; p.E85K; 9:83975466-83975466	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.740G>A; p.R247H; 9:83972095-83972095	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.740G>A; p.R247H; 9:83972095-83972095	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1298G>A; p.R433Q; 9:83970225-83970225	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1068A>T; p.E356D; 9:83971297-83971297	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1362-9_1362-5delCTTTT; p.?; 9:83969445-83969449	oesophagus	carcinoma; adenocarcinoma	Unknown
c.104G>A; p.R35K; 9:83977741-83977741	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.964G>A; p.A322T; 9:83971716-83971716	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1282G>C; p.E428Q; 9:83970241-83970241	parathyroid	carcinoma	Substitution - Missense
c.137G>A; p.R46H; 9:83977708-83977708	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.137G>A; p.R46H; 9:83977708-83977708	urinary_tract; bladder	carcinoma	Substitution - Missense
c.206G>T; p.R69L; 9:83977002-83977002	liver	carcinoma	Substitution - Missense
c.45C>T; p.T15T; 9:83978208-83978208	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1303A>G; p.I435V; 9:83970220-83970220	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.509_510delTT; p.L170fs*20; 9:83973292-83973293	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - Frameshift
c.516+1G>T; p.?; 9:83973285-83973285	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.217A>G; p.N73D; 9:83975502-83975502	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.691G>A; p.D231N; 9:83972144-83972144	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.43A>C; p.T15P; 9:83978210-83978210	skin	malignant_melanoma	Substitution - Missense
c.1298G>T; p.R433L; 9:83970225-83970225	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1127G>A; p.G376D; 9:83970801-83970801	skin	malignant_melanoma	Substitution - Missense
c.1127G>A; p.G376D; 9:83970801-83970801	skin	malignant_melanoma	Substitution - Missense
c.1127G>A; p.G376D; 9:83970801-83970801	skin	malignant_melanoma	Substitution - Missense
c.765G>A; p.M255I; 9:83972070-83972070	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.766C>T; p.R256W; 9:83972069-83972069	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.546G>T; p.Q182H; 9:83972943-83972943	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.546G>T; p.Q182H; 9:83972943-83972943	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.213_213+1insTA; p.N73fs*17; 9:83976994-83976995	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.224G>C; p.S75T; 9:83975495-83975495	breast	carcinoma	Substitution - Missense
c.821C>T; p.P274L; 9:83972014-83972014	skin	malignant_melanoma	Substitution - Missense
c.1240C>T; p.R414C; 9:83970283-83970283	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.155A>T; p.K52M; 9:83977690-83977690	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.844_846delGAT; p.D282delD; 9:83971989-83971991	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - In frame
c.598G>A; p.D200N; 9:83972891-83972891	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1071G>A; p.W357*; 9:83971294-83971294	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1353G>C; p.L451L; 9:83970170-83970170	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.593A>G; p.K198R; 9:83972896-83972896	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.593A>G; p.K198R; 9:83972896-83972896	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.911C>T; p.A304V; 9:83971924-83971924	skin	malignant_melanoma	Substitution - Missense
c.911C>T; p.A304V; 9:83971924-83971924	skin	malignant_melanoma	Substitution - Missense
c.554G>T; p.C185F; 9:83972935-83972935	ovary	other; neoplasm	Substitution - Missense
c.258-8T>G; p.?; 9:83974597-83974597	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Unknown
c.516G>C; p.E172D; 9:83973286-83973286	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.784G>C; p.D262H; 9:83972051-83972051	urinary_tract; bladder	carcinoma	Substitution - Missense
c.262T>A; p.L88M; 9:83974585-83974585	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.68C>A; p.P23H; 9:83977777-83977777	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.385G>C; p.A129P; 9:83973919-83973919	liver	carcinoma	Substitution - Missense
c.507A>T; p.E169D; 9:83973295-83973295	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.213+7A>G; p.?; 9:83976988-83976988	stomach	carcinoma; adenocarcinoma	Unknown
c.1260G>A; p.S420S; 9:83970263-83970263	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.565A>G; p.T189A; 9:83972924-83972924	urinary_tract; bladder	carcinoma	Substitution - Missense
c.376G>A; p.E126K; 9:83973928-83973928	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.931_933delCCA; p.P315delP; 9:83971902-83971904	large_intestine; colon	carcinoma	Deletion - In frame
c.933A>T; p.P311P; 9:83971902-83971902	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1267A>G; p.I423V; 9:83970256-83970256	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1109-1G>C; p.?; 9:83970820-83970820	ovary	other; neoplasm	Unknown
c.745C>T; p.R249C; 9:83972090-83972090	urinary_tract; bladder	carcinoma	Substitution - Missense
c.928C>T; p.P310S; 9:83971907-83971907	skin	malignant_melanoma	Substitution - Missense
c.92A>G; p.Q31R; 9:83977753-83977753	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1004G>A; p.G335D; 9:83971676-83971676	urinary_tract; bladder	carcinoma	Substitution - Missense
c.293G>T; p.G98V; 9:83974554-83974554	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.914G>A; p.R305Q; 9:83971921-83971921	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.42_43insTTCA; p.T15fs*5; 9:83978210-83978211	salivary_gland; parotid	carcinoma; adenoid_cystic_carcinoma	Insertion - Frameshift
c.926_931delTTCCTC; p.L309_P310delLP; 9:83971904-83971909	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.203_204delTC; p.L68fs*25; 9:83977004-83977005	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Deletion - Frameshift
c.1067A>C; p.E356A; 9:83971298-83971298	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]