Entrez Gene

Basic Information
Gene ID	2886
Name	GRB7
Synonymous	growth factor receptor-bound protein 7;GRB7;growth factor receptor-bound protein 7
Definition	B47\|GRB7 adapter protein\|epidermal growth factor receptor GRB-7
Position	17q12
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.253delG; p.G86fs*18; 17:39742663-39742663	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.939G>C; p.K313N; 17:39744912-39744912	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.272G>A; p.R91K; 17:39742682-39742682	skin	malignant_melanoma	Substitution - Missense
c.92C>T; p.P31L; 17:39742393-39742393	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1570C>T; p.R524C; 17:39746868-39746868	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.688C>T; p.P230S; 17:39744094-39744094	skin	malignant_melanoma	Substitution - Missense
c.385G>C; p.E129Q; 17:39742976-39742976	breast	carcinoma	Substitution - Missense
c.1225C>T; p.R409C; 17:39745743-39745743	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.795C>A; p.T265T; 17:39744201-39744201	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1145G>A; p.G382E; 17:39745474-39745474	skin	malignant_melanoma	Substitution - Missense
c.838G>A; p.E280K; 17:39744589-39744589	skin	malignant_melanoma	Substitution - Missense
c.1156G>C; p.E386Q; 17:39745485-39745485	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1156G>C; p.E386Q; 17:39745485-39745485	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.770G>T; p.G257V; 17:39744176-39744176	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.409G>A; p.A137T; 17:39743000-39743000	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.409G>A; p.A137T; 17:39743000-39743000	breast	carcinoma	Substitution - Missense
c.1407C>T; p.L469L; 17:39746157-39746157	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.616_625del10; p.S206fs*16; 17:39743423-39743432	lung	carcinoma; small_cell_carcinoma	Deletion - Frameshift
c.34A>G; p.S12G; 17:39742335-39742335	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.809G>A; p.R270K; 17:39744560-39744560	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.172G>T; p.E58*; 17:39742582-39742582	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.165A>T; p.R55R; 17:39742575-39742575	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.716G>T; p.R239L; 17:39744122-39744122	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2T>C; p.M1T; 17:39742303-39742303	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.246A>C; p.P82P; 17:39742656-39742656	thyroid	other; neoplasm	Substitution - coding silent
c.246A>C; p.P82P; 17:39742656-39742656	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.228T>G; p.S76R; 17:39742638-39742638	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.286C>T; p.R96C; 17:39742696-39742696	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.23C>T; p.P8L; 17:39742324-39742324	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1313G>A; p.R438H; 17:39745955-39745955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.42G>A; p.P14P; 17:39742343-39742343	skin	malignant_melanoma	Substitution - coding silent
c.1073G>C; p.C358S; 17:39745304-39745304	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.328G>A; p.D110N; 17:39742919-39742919	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.625G>A; p.D209N; 17:39743432-39743432	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.987G>T; p.W329C; 17:39744960-39744960	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1461G>A; p.E487E; 17:39746759-39746759	skin; arm	malignant_melanoma	Substitution - coding silent
c.1461G>A; p.E487E; 17:39746759-39746759	skin	malignant_melanoma	Substitution - coding silent
c.258C>T; p.G86G; 17:39742668-39742668	skin	malignant_melanoma	Substitution - coding silent
c.680G>A; p.G227D; 17:39744086-39744086	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.947G>A; p.R316Q; 17:39744920-39744920	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.947G>A; p.R316Q; 17:39744920-39744920	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.767C>G; p.S256C; 17:39744173-39744173	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.1299C>A; p.H433Q; 17:39745941-39745941	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.656T>C; p.L219P; 17:39743463-39743463	skin	malignant_melanoma	Substitution - Missense
c.1260C>A; p.S420R; 17:39745778-39745778	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.86G>A; p.R29Q; 17:39742387-39742387	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1082C>T; p.S361F; 17:39745313-39745313	thyroid	carcinoma	Substitution - Missense
c.1163C>T; p.P388L; 17:39745492-39745492	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.657C>T; p.L219L; 17:39743464-39743464	skin	malignant_melanoma	Substitution - coding silent
c.113_121delAGGTAAAGA; p.E38_R41>G; 17:39742414-39742422	stomach	carcinoma; intestinal_adenocarcinoma	Complex - deletion inframe
c.189C>T; p.S63S; 17:39742599-39742599	skin	malignant_melanoma	Substitution - coding silent
c.208_209CC>TT; p.P70F; 17:39742618-39742619	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.761G>A; p.R254H; 17:39744167-39744167	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.761G>A; p.R254H; 17:39744167-39744167	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1432A>C; p.K478Q; 17:39746182-39746182	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1432A>C; p.K478Q; 17:39746182-39746182	liver	carcinoma	Substitution - Missense
c.624C>T; p.L208L; 17:39743431-39743431	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.217G>A; p.E73K; 17:39742627-39742627	skin	malignant_melanoma	Substitution - Missense
c.1011+3G>C; p.?; 17:39744987-39744987	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.1045G>A; p.A349T; 17:39745276-39745276	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1A>G; p.M1V; 17:39742302-39742302	liver	carcinoma	Substitution - Missense
c.1445T>C; p.I482T; 17:39746195-39746195	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.185C>T; p.T62I; 17:39742595-39742595	skin	malignant_melanoma	Substitution - Missense
c.917A>G; p.N306S; 17:39744890-39744890	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.164G>A; p.R55Q; 17:39742574-39742574	breast	carcinoma	Substitution - Missense
c.1070C>G; p.S357C; 17:39745301-39745301	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1251C>T; p.S417S; 17:39745769-39745769	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.869G>A; p.R290H; 17:39744620-39744620	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1055G>A; p.R352H; 17:39745286-39745286	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.392T>A; p.L131Q; 17:39742983-39742983	breast	carcinoma	Substitution - Missense
c.1270G>A; p.A424T; 17:39745788-39745788	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.590C>T; p.S197F; 17:39743397-39743397	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1202C>T; p.A401V; 17:39745531-39745531	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.379G>A; p.V127M; 17:39742970-39742970	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1241T>C; p.M414T; 17:39745759-39745759	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.443G>T; p.C148F; 17:39743034-39743034	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.414G>C; p.L138F; 17:39743005-39743005	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1119G>A; p.V373V; 17:39745448-39745448	skin	malignant_melanoma	Substitution - coding silent
c.410C>T; p.A137V; 17:39743001-39743001	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.537C>T; p.F179F; 17:39743253-39743253	ovary	other; neoplasm	Substitution - coding silent
c.537C>T; p.F179F; 17:39743253-39743253	skin	malignant_melanoma	Substitution - coding silent
c.870C>T; p.R290R; 17:39744621-39744621	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1094G>T; p.R365I; 17:39745423-39745423	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.663G>T; p.Q221H; 17:39743470-39743470	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.57A>G; p.P19P; 17:39742358-39742358	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.120G>C; p.K40N; 17:39742421-39742421	breast	carcinoma	Substitution - Missense
c.372T>A; p.A124A; 17:39742963-39742963	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1108A>G; p.N370D; 17:39745437-39745437	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.847G>A; p.V283M; 17:39744598-39744598	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1460A>C; p.E487A; 17:39746758-39746758	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.546G>A; p.R182R; 17:39743262-39743262	skin	malignant_melanoma	Substitution - coding silent
c.287delG; p.R96fs*8; 17:39742697-39742697	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1115T>C; p.L372P; 17:39745444-39745444	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.583C>T; p.P195S; 17:39743299-39743299	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1304G>A; p.R435H; 17:39745946-39745946	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1304G>A; p.R435H; 17:39745946-39745946	prostate	carcinoma	Substitution - Missense
c.1304G>A; p.R435H; 17:39745946-39745946	central_nervous_system; brain	glioma	Substitution - Missense
c.1304G>A; p.R435H; 17:39745946-39745946	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1309T>C; p.S437P; 17:39745951-39745951	skin	malignant_melanoma	Substitution - Missense
c.892G>A; p.D298N; 17:39744643-39744643	skin	malignant_melanoma	Substitution - Missense
c.188C>T; p.S63F; 17:39742598-39742598	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.532C>T; p.R178C; 17:39743248-39743248	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1046_1047delCA; p.Q350fs*20; 17:39745277-39745278	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1454G>A; p.S485N; 17:39746752-39746752	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.776A>G; p.Y259C; 17:39744182-39744182	lung	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]