Cancer metastasis gene database Home
Cancer metastasis database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

2784

Name

GNB3

Synonymous

guanine nucleotide binding protein (G protein), beta polypeptide 3;GNB3;guanine nucleotide binding protein (G protein), beta polypeptide 3

Definition

G protein, beta-3 subunit|GTP-binding regulatory protein beta-3 chain|guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3|guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3|hypertension associated protein|transducin beta chain 3

Position

12p13

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.388G>T; p.E130*; 12:6843483-6843483

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.431-2A>T; p.?; 12:6843630-6843630

 lungcarcinoma; squamous_cell_carcinomaUnknown

c.778G>A; p.E260K; 12:6845664-6845664

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.680C>G; p.S227W; 12:6843959-6843959

 skinmalignant_melanomaSubstitution - Missense

c.15G>A; p.E5E; 12:6841302-6841302

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.929G>C; p.G310A; 12:6846804-6846804

 thyroidother; neoplasmSubstitution - Missense

c.822G>A; p.T274T; 12:6845708-6845708

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.367A>G; p.I123V; 12:6843462-6843462

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.226G>T; p.D76Y; 12:6843196-6843196

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.959T>C; p.V320A; 12:6846834-6846834

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.959T>C; p.V320A; 12:6846834-6846834

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.70G>C; p.A24P; 12:6841598-6841598

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.766C>G; p.R256G; 12:6845652-6845652

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.969C>T; p.D323D; 12:6846844-6846844

 skinmalignant_melanomaSubstitution - coding silent

c.383C>T; p.S128F; 12:6843478-6843478

 skinmalignant_melanomaSubstitution - Missense

c.873C>T; p.D291D; 12:6845759-6845759

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.794C>T; p.S265F; 12:6845680-6845680

 skinmalignant_melanomaSubstitution - Missense

c.597C>T; p.F199F; 12:6843876-6843876

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.867C>T; p.Y289Y; 12:6845753-6845753

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.848G>A; p.R283H; 12:6845734-6845734

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.240C>T; p.I80I; 12:6843210-6843210

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.410G>A; p.R137Q; 12:6843505-6843505

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.848G>A; p.R283H; 12:6845734-6845734

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.848G>A; p.R283H; 12:6845734-6845734

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.848G>A; p.R283H; 12:6845734-6845734

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.220T>G; p.S74A; 12:6843190-6843190

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.842G>A; p.S281N; 12:6845728-6845728

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.875T>C; p.F292S; 12:6845761-6845761

 thyroidother; neoplasmSubstitution - Missense

c.457G>T; p.D153Y; 12:6843658-6843658

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.921C>T; p.I307I; 12:6846796-6846796

 breastcarcinomaSubstitution - coding silent

c.512T>G; p.I171S; 12:6843791-6843791

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.825C>T; p.S275S; 12:6845711-6845711

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.825C>T; p.S275S; 12:6845711-6845711

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.687C>G; p.I229M; 12:6843966-6843966

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.799G>A; p.E267K; 12:6845685-6845685

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.525G>A; p.Q175Q; 12:6843804-6843804

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.910C>T; p.R304C; 12:6845796-6845796

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.735G>A; p.S245S; 12:6845621-6845621

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.528G>A; p.Q176Q; 12:6843807-6843807

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.514G>A; p.E172K; 12:6843793-6843793

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.96+2T>A; p.?; 12:6841626-6841626

 large_intestine; colonadenomaUnknown

c.762C>T; p.D254D; 12:6845648-6845648

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.656G>A; p.R219H; 12:6843935-6843935

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.415C>T; p.L139F; 12:6843510-6843510

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.331T>G; p.F111V; 12:6843426-6843426

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.323C>T; p.S108L; 12:6843418-6843418

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.223C>T; p.Q75*; 12:6843193-6843193

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_leukaemiaSubstitution - Nonsense

c.149C>T; p.T50M; 12:6843022-6843022

 breastcarcinomaSubstitution - Missense

c.634G>A; p.D212N; 12:6843913-6843913

 skinmalignant_melanomaSubstitution - Missense

c.742G>A; p.A248T; 12:6845628-6845628

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.221C>T; p.S74L; 12:6843191-6843191

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.311delC; p.Y105fs*54; 12:6843406-6843406

 kidneycarcinoma; clear_cell_renal_cell_carcinomaDeletion - Frameshift

c.125G>A; p.R42Q; 12:6842998-6842998

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.12G>A; p.M4I; 12:6841299-6841299

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.12G>A; p.M4I; 12:6841299-6841299

 skinmalignant_melanomaSubstitution - Missense

c.141G>A; p.T47T; 12:6843014-6843014

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.646G>A; p.G216R; 12:6843925-6843925

 skinmalignant_melanomaSubstitution - Missense

c.157G>A; p.G53R; 12:6843030-6843030

 skinmalignant_melanomaSubstitution - Missense

c.76G>A; p.A26T; 12:6841604-6841604

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.59A>G; p.D20G; 12:6841587-6841587

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.317C>T; p.A106V; 12:6843412-6843412

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.488A>G; p.D163G; 12:6843689-6843689

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.28G>A; p.E10K; 12:6841315-6841315

 oesophaguscarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.824C>G; p.S275C; 12:6845710-6845710

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.814G>A; p.G272S; 12:6845700-6845700

 skinmalignant_melanomaSubstitution - Missense

c.691G>A; p.A231T; 12:6843970-6843970

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_leukaemiaSubstitution - Missense

c.691G>A; p.A231T; 12:6843970-6843970

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.616G>T; p.A206S; 12:6843895-6843895

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.124C>T; p.R42*; 12:6842997-6842997

 breastcarcinomaSubstitution - Nonsense

c.124C>T; p.R42*; 12:6842997-6842997

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.776A>G; p.Q259R; 12:6845662-6845662

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.132G>A; p.Q44Q; 12:6843005-6843005

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent