| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2784 |
Name | GNB3 |
Synonym | guanine nucleotide binding protein (G protein), beta polypeptide 3;GNB3;guanine nucleotide binding protein (G protein), beta polypeptide 3 |
Definition | G protein, beta-3 subunit|GTP-binding regulatory protein beta-3 chain|guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3|guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3|hypertension associated protein|transducin beta chain 3 |
Position | 12p13 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway;PANTHER;P00027 |
Pathway | Metabotropic glutamate receptor group III pathway;PANTHER;P00039 |
Pathway | Integration of energy metabolism;Reactome;REACT:1505 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | GABA-B receptor II signaling;PANTHER;P05731 |
Pathway | 5HT4 type receptor mediated signaling pathway;PANTHER;P04376 |
Pathway | 5HT2 type receptor mediated signaling pathway;PANTHER;P04374 |
Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway;PANTHER;P00042 |
Pathway | Transmembrane transport of small molecules;Reactome;REACT:15518 |
Pathway | Thyrotropin-releasing hormone receptor signaling pathway;PANTHER;P04394 |
Pathway | Beta3 adrenergic receptor signaling pathway;PANTHER;P04379 |
Pathway | Metabotropic glutamate receptor group II pathway;PANTHER;P00040 |
Pathway | Opioid Signalling;Reactome;REACT:15295 |
Pathway | Cortocotropin releasing factor receptor signaling pathway;PANTHER;P04380 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Pathway | Histamine H2 receptor mediated signaling pathway;PANTHER;P04386 |
Pathway | 5HT1 type receptor mediated signaling pathway;PANTHER;P04373 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | PI3 kinase pathway;PANTHER;P00048 |
Pathway | Endogenous cannabinoid signaling;PANTHER;P05730 |
Pathway | Taste transduction;KEGG PATHWAY;hsa04742 |
Pathway | Histamine H1 receptor mediated signaling pathway;PANTHER;P04385 |
Pathway | Beta2 adrenergic receptor signaling pathway;PANTHER;P04378 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Synaptic Transmission;Reactome;REACT:13685 |
Pathway | Oxytocin receptor mediated signaling pathway;PANTHER;P04391 |
Pathway | Muscarinic acetylcholine receptor 2 and 4 signaling pathway;PANTHER;P00043 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | Beta1 adrenergic receptor signaling pathway;PANTHER;P04377 |
Pathway | Visual signal transduction: Cones;PID Curated;200078 |
Disease | Gastroesophageal Reflux;GAD |
Disease | autonomic nervous system;GAD |
Disease | depression;GAD |
Disease | cardiovascular;GAD |
Disease | lipids;GAD |
Disease | Hypertension, essential, susceptibility to;OMIM |
Disease | depression and response to antidepressant treatment;GAD |
Disease | obesity;GAD |
Disease | radial artery hypertrophy;GAD |
Disease | DEVELOPMENTAL;GAD |
Disease | hypertension;GAD |
Disease | Irritable Bowel Syndrome;GAD |
Disease | seasonal affective disorder;GAD |
Disease | IMMUNE;GAD |
Disease | serum potassium and total cholesterol levels but not;GAD |
Disease | METABOLIC;GAD |
Disease | Coronary Artery Disease;GAD |
Disease | glucose tolerance;GAD |
Disease | arterial wall changes;GAD |
Disease | Dyspepsia;GAD |
Disease | diabetes, type 2;GAD |
Disease | PSYCH;GAD |
Disease | coronary artery vasoconstriction.;GAD |
Disease | hypertension and obesity;GAD |
Disease | depressive disorder, major;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Stroke;GAD |
Disease | insulin;GAD |
Disease | insulin sensitivity;GAD |
Disease | enhanced atrial inward rectifier potassium currents;GAD |
Disease | Myocardial Infarction;GAD |
Disease | NORMALVARIATION;GAD |
Disease | left ventricular hypertrophy;GAD |
Disease | Venous response to nitroglycerin;GAD |
Disease | atherosclerosis, generalized;GAD |
Disease | major and bipolar depressives;GAD |
Disease | blood pressure, arterial;GAD |
Disease | body mass;GAD |
Disease | heart rate;GAD |
Disease | vasoconstriction, coronary;GAD |
Disease | elite athletes;GAD |
Disease | hypertension and left ventricular mass;GAD |
Disease | blood and blood forming organ disorders;GAD |
Disease | limb deficiency anomalies;GAD |
Disease | grade II hypertension;GAD |
Disease | normal variation;GAD |
Disease | reduced kidney allograft survival;GAD |
External Links | |
Links to Entrez Gene | 2784 |
Links to all GeneRIF Items | 2784 |
Links to iHOP | 2784 |
Sequence Information | |
Nucleotide Sequence | >2784 : length: 1760 ACCCTTCCCTGTCAGGCCCCCCCAACCCCCCGCCGGTCGGGGCCAGGCCAGGCCAGGCCA GCTCCTCTGGCAGCAGAGCCTGGGCAGGTGACGGGCGGGCGCGGGCGTCGCAGCTGAGGG AGTAAGGAGGCTCCCAGGAACCGGAGCTGGAAACCCGGCCGAGGTCCAGCCAGAGCCCAA GAGCCAGAGTGACCCCTCGACCTGTCAGCCATGGGGGAGATGGAGCAACTGCGTCAGGAA GCGGAGCAGCTCAAGAAGCAGATTGCAGATGCCAGGAAAGCCTGTGCTGACGTTACTCTG GCAGAGCTGGTGTCTGGCCTAGAGGTGGTGGGACGAGTCCAGATGCGGACGCGGCGGACG TTAAGGGGACACCTGGCCAAGATTTACGCCATGCACTGGGCCACTGATTCTAAGCTGCTG GTAAGTGCCTCGCAAGATGGGAAGCTGATCGTGTGGGACAGCTACACCACCAACAAGGTG CACGCCATCCCACTGCGCTCCTCCTGGGTCATGACCTGTGCCTATGCCCCATCAGGGAAC TTTGTGGCATGTGGGGGGCTGGACAACATGTGTTCCATCTACAACCTCAAATCCCGTGAG GGCAATGTCAAGGTCAGCCGGGAGCTTTCTGCTCACACAGGTTATCTCTCCTGCTGCCGC TTCCTGGATGACAACAATATTGTGACCAGCTCGGGGGACACCACGTGTGCCTTGTGGGAC ATTGAGACTGGGCAGCAGAAGACTGTATTTGTGGGACACACGGGTGACTGCATGAGCCTG GCTGTGTCTCCTGACTTCAATCTCTTCATTTCGGGGGCCTGTGATGCCAGTGCCAAGCTC TGGGATGTGCGAGAGGGGACCTGCCGTCAGACTTTCACTGGCCACGAGTCGGACATCAAC GCCATCTGTTTCTTCCCCAATGGAGAGGCCATCTGCACGGGCTCGGATGACGCTTCCTGC CGCTTGTTTGACCTGCGGGCAGACCAGGAGCTGATCTGCTTCTCCCACGAGAGCATCATC TGCGGCATCACGTCCGTGGCCTTCTCCCTCAGTGGCCGCCTACTATTCGCTGGCTACGAC GACTTCAACTGCAATGTCTGGGACTCCATGAAGTCTGAGCGTGTGGGCATCCTCTCTGGC CACGATAACAGGGTGAGCTGCCTGGGAGTCACAGCTGACGGGATGGCTGTGGCCACAGGT TCCTGGGACAGCTTCCTCAAAATCTGGAACTGAGGAGGCTGGAGAAAGGGAAGTGGAAGG CAGTGAACACACTCAGCAGCCCCCTGCCCGACCCCATCTCATTCAGGTGTTCTCTTCTAT ATTCCGGGTGCCATTCCCACTAAGCTTTCTCCTTTGAGGGCAGTGGGGAGCATGGGACTG TGCCTTTGGGAGGCAGCATCAGGGACACAGGGGCAAAGAACTGCCCCATCTCCTCCCATG GCCTTCCCTCCCCACAGTCCTCACAGCCTCTCCCTTAATGAGCAAGGACAACCTGCCCCT CCCCAGCCCTTTGCAGGCCCAGCAGACTTGAGTCTGAGGCCCCAGGCCCTAGGATTCCTC CCCCAGAGCCACTACCTTTGTCCAGGCCTGGGTGGTATAGGGCGTTTGGCCCTGTGACTA TGGCTCTGGCACCACTAGGGTCCTGGCCCTCTTCTTATTCATGCTTTCTCCTTTTTCTAC CTTTTTTTCTCTCCTAAGACACCTGCAATAAAGTGTAGCACCCTGGTACAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAA |
Protein Sequence | >2784 : length: 360 MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYA MHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNM CSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVF VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEA ICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM KSERVGKGQPWLLLPQLEGPSPALPPHSVPPISSHFGLSYCCPLSLGDSTPGIQYPLVPN |