Entrez Gene

Basic Information
Gene ID	246
Name	ALOX15
Synonymous	arachidonate 15-lipoxygenase;ALOX15;arachidonate 15-lipoxygenase
Definition	12/15-lipoxygenase\|15-LOX\|15-lipooxygenase-1\|arachidonate 12-lipoxygenase, leukocyte-type\|arachidonate omega-6 lipoxygenase
Position	17p13.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1906G>A; p.E636K; 17:4631683-4631683	skin	malignant_melanoma	Substitution - Missense
c.1935C>T; p.D645D; 17:4631654-4631654	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1139C>T; p.P380L; 17:4635781-4635781	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1194A>C; p.E398D; 17:4633468-4633468	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1194A>C; p.E398D; 17:4633468-4633468	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1680G>A; p.T560T; 17:4632018-4632018	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1680G>A; p.T560T; 17:4632018-4632018	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1680G>A; p.T560T; 17:4632018-4632018	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1684C>T; p.R562W; 17:4632014-4632014	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.949C>T; p.Q317*; 17:4637117-4637117	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1161+2T>C; p.?; 17:4635757-4635757	stomach	carcinoma; adenocarcinoma	Unknown
c.1397G>A; p.R466Q; 17:4633167-4633167	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1073A>T; p.Q358L; 17:4635847-4635847	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1546C>T; p.P516S; 17:4632276-4632276	skin	malignant_melanoma	Substitution - Missense
c.1499G>A; p.R500Q; 17:4632902-4632902	liver	carcinoma	Substitution - Missense
c.1239T>G; p.I413M; 17:4633423-4633423	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1499G>A; p.R500Q; 17:4632902-4632902	skin	malignant_melanoma	Substitution - Missense
c.1621G>A; p.A541T; 17:4632201-4632201	breast	carcinoma	Substitution - Missense
c.1265G>T; p.G422V; 17:4633299-4633299	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.823G>A; p.E275K; 17:4637243-4637243	skin	malignant_melanoma	Substitution - Missense
c.823G>A; p.E275K; 17:4637243-4637243	skin	malignant_melanoma	Substitution - Missense
c.1161+6T>C; p.?; 17:4635753-4635753	liver	carcinoma	Unknown
c.1747T>C; p.F583L; 17:4631951-4631951	breast	carcinoma	Substitution - Missense
c.862G>A; p.V288I; 17:4637204-4637204	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.561C>T; p.I187I; 17:4638666-4638666	skin	malignant_melanoma	Substitution - coding silent
c.384G>A; p.R128R; 17:4639086-4639086	skin; arm	malignant_melanoma	Substitution - coding silent
c.1795C>T; p.R599C; 17:4631903-4631903	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.715G>A; p.V239M; 17:4638309-4638309	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.168T>C; p.Y56Y; 17:4639599-4639599	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.715G>A; p.V239M; 17:4638309-4638309	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.715G>A; p.V239M; 17:4638309-4638309	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.715G>A; p.V239M; 17:4638309-4638309	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.168T>C; p.Y56Y; 17:4639599-4639599	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1357C>A; p.L453M; 17:4633207-4633207	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1357C>A; p.L453M; 17:4633207-4633207	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.715G>A; p.V239M; 17:4638309-4638309	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.715G>A; p.V239M; 17:4638309-4638309	breast	carcinoma	Substitution - Missense
c.715G>A; p.V239M; 17:4638309-4638309	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1357C>A; p.L453M; 17:4633207-4633207	large_intestine; colon	carcinoma	Substitution - Missense
c.1357C>A; p.L453M; 17:4633207-4633207	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1819G>A; p.G607S; 17:4631770-4631770	salivary_gland; submandibular	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.556G>A; p.A186T; 17:4638671-4638671	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1540G>A; p.G514R; 17:4632861-4632861	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1188C>T; p.T396T; 17:4633474-4633474	skin	malignant_melanoma	Substitution - coding silent
c.1188C>T; p.T396T; 17:4633474-4633474	skin	malignant_melanoma	Substitution - coding silent
c.337G>A; p.G113S; 17:4639430-4639430	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1625C>G; p.S542C; 17:4632197-4632197	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.341G>A; p.R114H; 17:4639129-4639129	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1396C>T; p.R466W; 17:4633168-4633168	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.930A>G; p.K310K; 17:4637136-4637136	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1015G>T; p.A339S; 17:4635905-4635905	kidney	other; neoplasm	Substitution - Missense
c.759C>T; p.F253F; 17:4638265-4638265	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.759C>T; p.F253F; 17:4638265-4638265	thyroid	other; neoplasm	Substitution - coding silent
c.1434C>T; p.I478I; 17:4632967-4632967	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - coding silent
c.354G>A; p.E118E; 17:4639116-4639116	skin	malignant_melanoma	Substitution - coding silent
c.1656T>C; p.S552S; 17:4632042-4632042	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1819G>T; p.G607C; 17:4631770-4631770	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.948C>G; p.I316M; 17:4637118-4637118	breast	carcinoma	Substitution - Missense
c.1863T>G; p.A621A; 17:4631726-4631726	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1694C>T; p.P565L; 17:4632004-4632004	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1949A>G; p.Y650C; 17:4631640-4631640	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1551C>G; p.V517V; 17:4632271-4632271	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.849G>A; p.G283G; 17:4637217-4637217	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1343C>T; p.A448V; 17:4633221-4633221	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1391C>T; p.A464V; 17:4633173-4633173	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1391C>T; p.A464V; 17:4633173-4633173	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1241T>C; p.F414S; 17:4633421-4633421	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1235G>A; p.G412E; 17:4633427-4633427	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.1235G>A; p.G412E; 17:4633427-4633427	skin	malignant_melanoma	Substitution - Missense
c.1349G>A; p.R450Q; 17:4633215-4633215	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.948C>A; p.I316I; 17:4637118-4637118	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1604C>A; p.T535N; 17:4632218-4632218	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1344C>T; p.A448A; 17:4633220-4633220	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1796G>A; p.R599H; 17:4631902-4631902	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.808-1G>A; p.?; 17:4637259-4637259	skin	malignant_melanoma	Unknown
c.952-2A>G; p.?; 17:4635970-4635970	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1760C>G; p.S587C; 17:4631938-4631938	urinary_tract; bladder	carcinoma	Substitution - Missense
c.349G>T; p.G117C; 17:4639121-4639121	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1458C>T; p.D486D; 17:4632943-4632943	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1217G>A; p.G406E; 17:4633445-4633445	skin	malignant_melanoma	Substitution - Missense
c.1613G>A; p.G538D; 17:4632209-4632209	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1162-2A>G; p.?; 17:4633502-4633502	thyroid	carcinoma; medullary_carcinoma	Unknown
c.314T>A; p.V105D; 17:4639453-4639453	skin	malignant_melanoma	Substitution - Missense
c.425G>A; p.G142E; 17:4638967-4638967	skin	malignant_melanoma	Substitution - Missense
c.112C>T; p.R38*; 17:4641540-4641540	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1035C>T; p.C345C; 17:4635885-4635885	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1641+1G>T; p.?; 17:4632180-4632180	lung	carcinoma; adenocarcinoma	Unknown
c.1273C>T; p.H425Y; 17:4633291-4633291	skin	malignant_melanoma	Substitution - Missense
c.577G>T; p.V193F; 17:4638650-4638650	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1579C>T; p.H527Y; 17:4632243-4632243	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.895C>T; p.P299S; 17:4637171-4637171	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.298G>A; p.V100M; 17:4639469-4639469	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.10_18delTACCGCATC; p.Y4_I6delYRI; 17:4641634-4641642	soft_tissue; blood_vessel	angiosarcoma	Deletion - In frame
c.942G>A; p.M314I; 17:4637124-4637124	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1617A>G; p.Q539Q; 17:4632205-4632205	skin	malignant_melanoma	Substitution - coding silent
c.309C>G; p.N103K; 17:4639458-4639458	thyroid	other; neoplasm	Substitution - Missense
c.856G>A; p.A286T; 17:4637210-4637210	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.595G>T; p.D199Y; 17:4638632-4638632	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1373C>T; p.S458F; 17:4633191-4633191	skin	malignant_melanoma	Substitution - Missense
c.384G>C; p.R128R; 17:4639086-4639086	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.706G>T; p.A236S; 17:4638318-4638318	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1247A>G; p.Q416R; 17:4633415-4633415	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.236A>G; p.N79S; 17:4639531-4639531	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1366A>G; p.K456E; 17:4633198-4633198	skin	malignant_melanoma	Substitution - Missense
c.1812G>A; p.V604V; 17:4631777-4631777	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.271G>A; p.E91K; 17:4639496-4639496	urinary_tract; bladder	carcinoma	Substitution - Missense
c.271G>A; p.E91K; 17:4639496-4639496	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.271G>A; p.E91K; 17:4639496-4639496	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1072C>T; p.Q358*; 17:4635848-4635848	lung	carcinoma; non_small_cell_carcinoma	Substitution - Nonsense
c.1003G>A; p.D335N; 17:4635917-4635917	skin	malignant_melanoma	Substitution - Missense
c.1172C>T; p.P391L; 17:4633490-4633490	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1378T>C; p.Y460H; 17:4633186-4633186	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1498C>T; p.R500*; 17:4632903-4632903	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1620C>T; p.H540H; 17:4632202-4632202	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.408G>A; p.R136R; 17:4639062-4639062	skin	malignant_melanoma	Substitution - coding silent
c.1455A>G; p.T485T; 17:4632946-4632946	thyroid	other; neoplasm	Substitution - coding silent
c.822C>T; p.F274F; 17:4637244-4637244	skin	malignant_melanoma	Substitution - coding silent
c.1835A>G; p.E612G; 17:4631754-4631754	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1905G>A; p.K635K; 17:4631684-4631684	skin; nipple	malignant_melanoma	Substitution - coding silent
c.1847G>A; p.G616D; 17:4631742-4631742	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.547G>A; p.A183T; 17:4638680-4638680	skin	malignant_melanoma	Substitution - Missense
c.1056C>A; p.F352L; 17:4635864-4635864	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1783C>T; p.Q595*; 17:4631915-4631915	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1516G>A; p.G506R; 17:4632885-4632885	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1516G>A; p.G506R; 17:4632885-4632885	pancreas	carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]