Entrez Gene

Basic Information
Gene ID	239
Name	ALOX12
Synonymous	arachidonate 12-lipoxygenase;ALOX12;arachidonate 12-lipoxygenase
Definition	12(S)-lipoxygenase\|12S-lipoxygenase\|arachidonate 12-lipoxygenase, 12S-type\|lipoxin synthase 12-LO\|platelet 12-LOX\|platelet-type 12-lipoxygenase\|platelet-type lipoxygenase 12
Position	17p13.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.8G>T; p.R3L; 17:6996125-6996125	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.214G>A; p.V72M; 17:6996904-6996904	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.457G>A; p.A153T; 17:6998752-6998752	prostate	carcinoma	Substitution - Missense
c.1902G>A; p.L634L; 17:7010333-7010333	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1288C>A; p.R430S; 17:7005897-7005897	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1175A>G; p.H392R; 17:7005270-7005270	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.884A>C; p.Y295S; 17:7000412-7000412	breast	carcinoma	Substitution - Missense
c.263C>T; p.A88V; 17:6996953-6996953	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1642C>T; p.L548L; 17:7009956-7009956	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.219C>T; p.D73D; 17:6996909-6996909	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1508C>T; p.T503M; 17:7006575-7006575	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.378G>A; p.K126K; 17:6998549-6998549	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1812G>A; p.M604I; 17:7010126-7010126	skin	malignant_melanoma	Substitution - Missense
c.1888G>A; p.D630N; 17:7010319-7010319	skin	malignant_melanoma	Substitution - Missense
c.1781C>G; p.S594*; 17:7010095-7010095	breast	carcinoma	Substitution - Nonsense
c.1920C>T; p.A640A; 17:7010351-7010351	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1776_1785del10; p.S594fs*1; 17:7010090-7010099	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.1057C>A; p.Q353K; 17:7001707-7001707	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.590G>A; p.W197*; 17:6999000-6999000	thyroid	carcinoma	Substitution - Nonsense
c.1086G>A; p.L362L; 17:7001736-7001736	breast	carcinoma	Substitution - coding silent
c.862G>A; p.V288M; 17:7000390-7000390	prostate	carcinoma	Substitution - Missense
c.1138C>A; p.P380T; 17:7001788-7001788	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1114G>A; p.A372T; 17:7001764-7001764	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1795C>A; p.R599S; 17:7010109-7010109	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1795C>A; p.R599S; 17:7010109-7010109	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.509A>C; p.K170T; 17:6998804-6998804	urinary_tract; bladder	carcinoma	Substitution - Missense
c.509A>C; p.K170T; 17:6998804-6998804	urinary_tract; bladder	carcinoma	Substitution - Missense
c.509A>C; p.K170T; 17:6998804-6998804	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.670G>A; p.D224N; 17:6999329-6999329	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.517G>A; p.D173N; 17:6998812-6998812	skin	malignant_melanoma	Substitution - Missense
c.1428G>C; p.E476D; 17:7006495-7006495	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1428G>C; p.E476D; 17:7006495-7006495	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1038G>A; p.W346*; 17:7001688-7001688	skin	malignant_melanoma	Substitution - Nonsense
c.1201A>C; p.T401P; 17:7005296-7005296	breast	carcinoma	Substitution - Missense
c.655C>T; p.R219C; 17:6999314-6999314	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.813T>C; p.G271G; 17:7000341-7000341	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1602C>T; p.F534F; 17:7009808-7009808	oesophagus	carcinoma	Substitution - coding silent
c.965A>G; p.N322S; 17:7001615-7001615	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.309G>C; p.E103D; 17:6996999-6996999	breast	carcinoma	Substitution - Missense
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	thyroid	other; neoplasm	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.625G>A; p.G209S; 17:6999035-6999035	skin	malignant_melanoma	Substitution - Missense
c.1684C>T; p.R562W; 17:7009998-7009998	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1911G>A; p.E637E; 17:7010342-7010342	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1684C>T; p.R562W; 17:7009998-7009998	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	thyroid	other; neoplasm	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	thyroid	other; neoplasm	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.123C>G; p.P41P; 17:6996240-6996240	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1684C>T; p.R562W; 17:7009998-7009998	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.203A>G; p.H68R; 17:6996893-6996893	skin	malignant_melanoma	Substitution - Missense
c.1115C>A; p.A372D; 17:7001765-7001765	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1115C>A; p.A372D; 17:7001765-7001765	large_intestine; colon	carcinoma	Substitution - Missense
c.844G>A; p.D282N; 17:7000372-7000372	skin	malignant_melanoma	Substitution - Missense
c.1348_1349CG>AA; p.R450K; 17:7005957-7005958	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1689G>A; p.M563I; 17:7010003-7010003	breast	carcinoma	Substitution - Missense
c.306C>T; p.G102G; 17:6996996-6996996	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.945C>G; p.V315V; 17:7000473-7000473	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1292G>A; p.R431Q; 17:7005901-7005901	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1212G>T; p.R404R; 17:7005307-7005307	thyroid	carcinoma	Substitution - coding silent
c.1624G>A; p.A542T; 17:7009830-7009830	breast	carcinoma	Substitution - Missense
c.431G>A; p.W144*; 17:6998726-6998726	skin	malignant_melanoma	Substitution - Nonsense
c.1213A>G; p.T405A; 17:7005308-7005308	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1213A>G; p.T405A; 17:7005308-7005308	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1200C>A; p.N400K; 17:7005295-7005295	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.35C>T; p.A12V; 17:6996152-6996152	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.196C>T; p.R66C; 17:6996886-6996886	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.647-1G>A; p.?; 17:6999305-6999305	skin; scalp	malignant_melanoma	Unknown
c.795G>C; p.E265D; 17:6999454-6999454	breast	carcinoma	Substitution - Missense
c.1795C>T; p.R599C; 17:7010109-7010109	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1272C>T; p.G424G; 17:7005881-7005881	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.550G>C; p.E184Q; 17:6998960-6998960	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.550G>C; p.E184Q; 17:6998960-6998960	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1170delC; p.H392fs*27; 17:7005265-7005265	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.359C>A; p.A120D; 17:6998530-6998530	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.727C>T; p.R243C; 17:6999386-6999386	prostate	carcinoma	Substitution - Missense
c.1092T>G; p.T364T; 17:7001742-7001742	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1091C>T; p.T364I; 17:7001741-7001741	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.170T>C; p.L57S; 17:6996860-6996860	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1092T>G; p.T364T; 17:7001742-7001742	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1011A>C; p.P337P; 17:7001661-7001661	breast	carcinoma	Substitution - coding silent
c.1685G>A; p.R562Q; 17:7009999-7009999	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.652G>A; p.V218I; 17:6999311-6999311	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.425C>A; p.A142D; 17:6998720-6998720	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1718C>T; p.T573M; 17:7010032-7010032	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1832A>G; p.K611R; 17:7010263-7010263	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1141G>A; p.G381R; 17:7001791-7001791	NS	malignant_melanoma	Substitution - Missense
c.1141G>A; p.G381R; 17:7001791-7001791	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.782A>G; p.Q261R; 17:6999441-6999441	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1141G>A; p.G381R; 17:7001791-7001791	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.782A>G; p.Q261R; 17:6999441-6999441	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1845C>A; p.F615L; 17:7010276-7010276	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1445T>C; p.F482S; 17:7006512-7006512	fallopian_tube	carcinoma; serous_carcinoma	Substitution - Missense
c.676G>A; p.E226K; 17:6999335-6999335	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1693C>A; p.P565T; 17:7010007-7010007	skin	malignant_melanoma	Substitution - Missense
c.669G>A; p.Q223Q; 17:6999328-6999328	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.749G>A; p.R250K; 17:6999408-6999408	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.142G>A; p.E48K; 17:6996832-6996832	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1961C>A; p.P654H; 17:7010392-7010392	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1966T>A; p.C656S; 17:7010397-7010397	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1765C>G; p.L589V; 17:7010079-7010079	oesophagus	carcinoma	Substitution - Missense
c.498C>T; p.F166F; 17:6998793-6998793	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1783T>A; p.W595R; 17:7010097-7010097	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.781C>T; p.Q261*; 17:6999440-6999440	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.688T>C; p.Y230H; 17:6999347-6999347	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1596C>T; p.C532C; 17:7009802-7009802	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1902G>C; p.L634L; 17:7010333-7010333	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1812+1G>A; p.?; 17:7010127-7010127	large_intestine; rectum	carcinoma; adenocarcinoma	Unknown
c.1449C>T; p.Y483Y; 17:7006516-7006516	skin	malignant_melanoma	Substitution - coding silent
c.1882C>T; p.R628*; 17:7010313-7010313	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Nonsense
c.765G>A; p.S255S; 17:6999424-6999424	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.765G>A; p.S255S; 17:6999424-6999424	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1913T>G; p.I638S; 17:7010344-7010344	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]