Entrez Gene

Basic Information
Gene ID	2214
Name	FCGR3A
Synonymous	Fc fragment of IgG, low affinity IIIa, receptor (CD16a);FCGR3A;Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Definition	CD16a antigen\|Fc fragment of IgG, low affinity III, receptor for (CD16)\|Fc gamma receptor III-A\|Fc-gamma RIII-alpha\|Fc-gamma RIIIa\|Fc-gamma receptor III-2 (CD 16)\|Fc-gamma receptor IIIb (CD16)\|FcgammaRIIIA\|fc-gamma RIII\|igG Fc receptor III-2\|immunoglobuli
Position	1q23
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.672C>T; p.I224I; 1:161544714-161544714	skin	malignant_melanoma	Substitution - coding silent
c.764T>G; p.F255C; 1:161543121-161543121	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.817A>G; p.T273A; 1:161543068-161543068	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.114G>T; p.W38C; 1:161549731-161549731	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.333C>T; p.F111F; 1:161548515-161548515	skin	malignant_melanoma	Substitution - coding silent
c.808C>T; p.R270*; 1:161543077-161543077	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.808C>T; p.R270*; 1:161543077-161543077	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.208T>C; p.W70R; 1:161548640-161548640	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.401A>G; p.D134G; 1:161548447-161548447	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.163C>T; p.R55W; 1:161549017-161549017	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.177C>T; p.L59L; 1:161548671-161548671	skin	malignant_melanoma	Substitution - coding silent
c.64G>T; p.G22W; 1:161549781-161549781	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.759C>T; p.L253L; 1:161543126-161543126	stomach	adenocarcinoma	Substitution - coding silent
c.308T>C; p.I103T; 1:161548540-161548540	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.611G>A; p.G204D; 1:161544775-161544775	skin	malignant_melanoma	Substitution - Missense
c.202C>G; p.P68A; 1:161548646-161548646	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.66G>C; p.G22G; 1:161549779-161549779	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.454T>G; p.W152G; 1:161544932-161544932	breast	carcinoma	Substitution - Missense
c.479T>G; p.I160S; 1:161544907-161544907	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.792T>C; p.S264S; 1:161543093-161543093	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.426C>T; p.I142I; 1:161548422-161548422	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.521A>G; p.K174R; 1:161544865-161544865	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.184G>T; p.A62S; 1:161548664-161548664	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.426C>T; p.I142I; 1:161548422-161548422	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.184G>T; p.A62S; 1:161548664-161548664	skin	malignant_melanoma	Substitution - Missense
c.841T>C; p.F281L; 1:161543044-161543044	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.841T>C; p.F281L; 1:161543044-161543044	urinary_tract; bladder	carcinoma	Substitution - Missense
c.841T>C; p.F281L; 1:161543044-161543044	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.600C>G; p.L200L; 1:161544786-161544786	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.266C>T; p.P89L; 1:161548582-161548582	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.124C>T; p.L42F; 1:161549721-161549721	skin	malignant_melanoma	Substitution - Missense
c.354C>T; p.D118D; 1:161548494-161548494	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.253G>A; p.G85R; 1:161548595-161548595	skin	malignant_melanoma	Substitution - Missense
c.303C>T; p.S101S; 1:161548545-161548545	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.630G>A; p.G210G; 1:161544756-161544756	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.714C>A; p.F238L; 1:161543171-161543171	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.292C>T; p.H98Y; 1:161548556-161548556	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.747G>T; p.L249F; 1:161543138-161543138	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.404C>A; p.P135Q; 1:161548444-161548444	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.34T>C; p.S12P; 1:161549811-161549811	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.433C>T; p.L145L; 1:161544953-161544953	skin	malignant_melanoma	Substitution - coding silent
c.709T>C; p.S237P; 1:161543176-161543176	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.512C>T; p.A171V; 1:161544874-161544874	skin	malignant_melanoma	Substitution - Missense
c.399T>A; p.S133R; 1:161548449-161548449	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.209G>T; p.W70L; 1:161548639-161548639	soft_tissue; fibrous_tissue_and_uncertain_o	solitary_fibrous_tumour; malignant	Substitution - Missense
c.586C>A; p.P196T; 1:161544800-161544800	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.190G>C; p.V64L; 1:161548658-161548658	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.289T>G; p.F97V; 1:161548559-161548559	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.305T>G; p.L102R; 1:161548543-161548543	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.305T>G; p.L102R; 1:161548543-161548543	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.305T>G; p.L102R; 1:161548543-161548543	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.708A>T; p.S236S; 1:161543177-161543177	skin	malignant_melanoma	Substitution - coding silent
c.396C>A; p.L132L; 1:161548452-161548452	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.634T>G; p.F212V; 1:161544752-161544752	thyroid	other; neoplasm	Substitution - Missense
c.128C>A; p.P43Q; 1:161549717-161549717	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.77C>A; p.S26Y; 1:161549768-161549768	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.387C>G; p.L129L; 1:161548461-161548461	breast	carcinoma	Substitution - coding silent
c.352G>A; p.D118N; 1:161548496-161548496	thyroid	other; neoplasm	Substitution - Missense
c.352G>A; p.D118N; 1:161548496-161548496	thyroid	other; neoplasm	Substitution - Missense
c.352G>A; p.D118N; 1:161548496-161548496	thyroid	other; neoplasm	Substitution - Missense
c.352G>A; p.D118N; 1:161548496-161548496	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.302G>A; p.S101N; 1:161548546-161548546	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.302G>A; p.S101N; 1:161548546-161548546	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.302G>A; p.S101N; 1:161548546-161548546	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.302G>A; p.S101N; 1:161548546-161548546	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.302G>A; p.S101N; 1:161548546-161548546	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.302G>A; p.S101N; 1:161548546-161548546	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.302G>A; p.S101N; 1:161548546-161548546	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.302G>A; p.S101N; 1:161548546-161548546	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.302G>A; p.S101N; 1:161548546-161548546	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.302G>A; p.S101N; 1:161548546-161548546	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.302G>A; p.S101N; 1:161548546-161548546	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.424A>G; p.I142V; 1:161548424-161548424	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.424A>G; p.I142V; 1:161548424-161548424	breast	carcinoma	Substitution - Missense
c.424A>G; p.I142V; 1:161548424-161548424	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.424A>G; p.I142V; 1:161548424-161548424	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.424A>G; p.I142V; 1:161548424-161548424	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.424A>G; p.I142V; 1:161548424-161548424	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.424A>G; p.I142V; 1:161548424-161548424	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.424A>G; p.I142V; 1:161548424-161548424	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.424A>G; p.I142V; 1:161548424-161548424	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.424A>G; p.I142V; 1:161548424-161548424	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.228G>A; p.K76K; 1:161548620-161548620	skin	malignant_melanoma	Substitution - coding silent
c.424A>G; p.I142V; 1:161548424-161548424	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.424A>G; p.I142V; 1:161548424-161548424	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.424A>G; p.I142V; 1:161548424-161548424	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.215G>A; p.R72K; 1:161548633-161548633	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.39C>T; p.S13S; 1:161549806-161549806	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.839A>C; p.K280T; 1:161543046-161543046	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.187G>A; p.V63M; 1:161548661-161548661	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.403C>A; p.P135T; 1:161548445-161548445	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.226A>T; p.K76*; 1:161548622-161548622	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.340G>T; p.A114S; 1:161548508-161548508	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.685G>A; p.G229S; 1:161544701-161544701	skin	malignant_melanoma	Substitution - Missense
c.668A>G; p.N223S; 1:161544718-161544718	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.451C>T; p.R151W; 1:161544935-161544935	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.92C>T; p.P31L; 1:161549753-161549753	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.270G>A; p.E90E; 1:161548578-161548578	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.762T>G; p.L254L; 1:161543123-161543123	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.604G>A; p.D202N; 1:161544782-161544782	skin	malignant_melanoma	Substitution - Missense
c.354C>A; p.D118E; 1:161548494-161548494	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.658G>C; p.E220Q; 1:161544728-161544728	breast	carcinoma	Substitution - Missense
c.373T>C; p.C125R; 1:161548475-161548475	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.331T>C; p.F111L; 1:161548517-161548517	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]