Entrez Gene

Basic Information
Gene ID	1644
Name	DDC
Synonymous	dopa decarboxylase (aromatic L-amino acid decarboxylase);DDC;dopa decarboxylase (aromatic L-amino acid decarboxylase)
Definition	aromatic-L-amino-acid decarboxylase
Position	7p12.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.726_727CC>TT; p.(=); 7:50504047-50504048	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.24G>A; p.R8R; 7:50544062-50544062	skin	malignant_melanoma	Substitution - coding silent
c.501G>T; p.L167L; 7:50529277-50529277	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.24G>A; p.R8R; 7:50544062-50544062	skin	malignant_melanoma	Substitution - coding silent
c.1178G>A; p.R393H; 7:50467278-50467278	liver	carcinoma	Substitution - Missense
c.419G>A; p.G140E; 7:50537876-50537876	skin	malignant_melanoma	Substitution - Missense
c.419G>A; p.G140E; 7:50537876-50537876	skin	malignant_melanoma	Substitution - Missense
c.176A>G; p.D59G; 7:50543910-50543910	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.721G>T; p.A241S; 7:50504053-50504053	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.554C>T; p.A185V; 7:50529224-50529224	liver	carcinoma	Substitution - Missense
c.795C>T; p.D265D; 7:50499229-50499229	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.496C>T; p.R166W; 7:50529282-50529282	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.790G>T; p.E264*; 7:50499234-50499234	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.241C>T; p.P81S; 7:50539989-50539989	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1108G>A; p.G370R; 7:50470105-50470105	skin	malignant_melanoma	Substitution - Missense
c.285C>T; p.C95C; 7:50539945-50539945	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.261G>A; p.P87P; 7:50539969-50539969	liver	carcinoma	Substitution - coding silent
c.1177C>T; p.R393C; 7:50467279-50467279	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1405G>A; p.E469K; 7:50463269-50463269	skin	malignant_melanoma	Substitution - Missense
c.1067G>T; p.R356I; 7:50470146-50470146	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.261G>A; p.P87P; 7:50539969-50539969	liver	carcinoma	Substitution - coding silent
c.423A>G; p.G141G; 7:50537872-50537872	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.681G>A; p.E227E; 7:50528170-50528170	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1159G>A; p.E387K; 7:50467297-50467297	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.538A>C; p.M180L; 7:50529240-50529240	liver	carcinoma	Substitution - Missense
c.538A>C; p.M180L; 7:50529240-50529240	liver	carcinoma	Substitution - Missense
c.369G>A; p.G123G; 7:50537926-50537926	skin	malignant_melanoma	Substitution - coding silent
c.369G>A; p.G123G; 7:50537926-50537926	skin	malignant_melanoma	Substitution - coding silent
c.1101G>A; p.R367R; 7:50470112-50470112	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.901C>T; p.P301S; 7:50495393-50495393	skin	malignant_melanoma	Substitution - Missense
c.551T>G; p.V184G; 7:50529227-50529227	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.823G>A; p.A275T; 7:50499201-50499201	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.87C>G; p.V29V; 7:50543999-50543999	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.93T>C; p.P31P; 7:50543993-50543993	skin	malignant_melanoma	Substitution - coding silent
c.1375C>T; p.H459Y; 7:50463299-50463299	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1375C>T; p.H459Y; 7:50463299-50463299	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1283A>C; p.N428T; 7:50463391-50463391	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.607G>T; p.G203*; 7:50528244-50528244	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.531C>A; p.A177A; 7:50529247-50529247	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1109G>A; p.G370E; 7:50470104-50470104	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1007G>A; p.S336N; 7:50479801-50479801	skin	malignant_melanoma	Substitution - Missense
c.1041+4_1041+5insA; p.?; 7:50476619-50476620	soft_tissue; blood_vessel	angiosarcoma	Unknown
c.115C>T; p.R39W; 7:50543971-50543971	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.343G>A; p.E115K; 7:50537952-50537952	skin	malignant_melanoma	Substitution - Missense
c.277A>G; p.M93V; 7:50539953-50539953	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1015G>A; p.D339N; 7:50479793-50479793	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1015G>A; p.D339N; 7:50479793-50479793	skin; trunk	malignant_melanoma	Substitution - Missense
c.155C>T; p.T52M; 7:50543931-50543931	central_nervous_system; brain	glioma	Substitution - Missense
c.1135C>T; p.R379C; 7:50470078-50470078	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.420G>A; p.G140G; 7:50537875-50537875	skin	malignant_melanoma	Substitution - coding silent
c.519G>C; p.E173D; 7:50529259-50529259	bone; fibula	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.570G>T; p.Q190H; 7:50529208-50529208	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.128C>T; p.P43L; 7:50543958-50543958	skin	malignant_melanoma	Substitution - Missense
c.1118G>A; p.G373E; 7:50470095-50470095	skin	malignant_melanoma	Substitution - Missense
c.537C>T; p.I179I; 7:50529241-50529241	skin	malignant_melanoma	Substitution - coding silent
c.320C>T; p.A107V; 7:50537975-50537975	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.373A>T; p.M125L; 7:50537922-50537922	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.171C>T; p.I57I; 7:50543915-50543915	skin	malignant_melanoma	Substitution - coding silent
c.177C>A; p.D59E; 7:50543909-50543909	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.364C>T; p.L122F; 7:50537931-50537931	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1191C>A; p.R397R; 7:50467265-50467265	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1191C>A; p.R397R; 7:50467265-50467265	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.255G>A; p.S85S; 7:50539975-50539975	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.543G>A; p.E181E; 7:50529235-50529235	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.175G>A; p.D59N; 7:50543911-50543911	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.56A>G; p.N19S; 7:50544030-50544030	skin	malignant_melanoma	Substitution - Missense
c.910T>C; p.W304R; 7:50495384-50495384	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.873G>A; p.V291V; 7:50499151-50499151	skin	malignant_melanoma	Substitution - coding silent
c.531C>T; p.A177A; 7:50529247-50529247	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.126C>T; p.I42I; 7:50543960-50543960	skin	malignant_melanoma	Substitution - coding silent
c.1332T>C; p.F444F; 7:50463342-50463342	skin	malignant_melanoma	Substitution - coding silent
c.1297delA; p.I433fs*>48; 7:50463377-50463377	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.531C>T; p.A177A; 7:50529247-50529247	pancreas	carcinoid-endocrine_tumour	Substitution - coding silent
c.1297delA; p.I433fs*>48; 7:50463377-50463377	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1297delA; p.I433fs*>48; 7:50463377-50463377	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1357C>T; p.R453C; 7:50463317-50463317	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1222C>T; p.L408F; 7:50467234-50467234	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1380G>T; p.V460V; 7:50463294-50463294	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.822C>T; p.Y274Y; 7:50499202-50499202	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.312C>T; p.S104S; 7:50539918-50539918	skin	malignant_melanoma	Substitution - coding silent
c.822C>T; p.Y274Y; 7:50499202-50499202	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.379G>T; p.E127*; 7:50537916-50537916	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1355C>T; p.S452F; 7:50463319-50463319	urinary_tract; bladder	carcinoma	Substitution - Missense
c.478C>T; p.R160W; 7:50529300-50529300	skin	malignant_melanoma	Substitution - Missense
c.956G>T; p.R319I; 7:50479852-50479852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.427G>A; p.V143M; 7:50537868-50537868	breast	carcinoma	Substitution - Missense
c.553G>A; p.A185T; 7:50529225-50529225	liver	carcinoma	Substitution - Missense
c.240C>T; p.F80F; 7:50539990-50539990	skin	malignant_melanoma	Substitution - coding silent
c.947T>G; p.V316G; 7:50479861-50479861	breast	carcinoma	Substitution - Missense
c.811G>T; p.D271Y; 7:50499213-50499213	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.315G>A; p.W105*; 7:50539915-50539915	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1419C>A; p.D473E; 7:50463255-50463255	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.788A>T; p.K263M; 7:50499236-50499236	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1427G>A; p.R476Q; 7:50463247-50463247	skin	malignant_melanoma	Substitution - Missense
c.1214T>C; p.I405T; 7:50467242-50467242	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.365T>G; p.L122R; 7:50537930-50537930	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.367G>A; p.G123R; 7:50537928-50537928	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.608G>C; p.G203A; 7:50528243-50528243	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1041+8G>A; p.?; 7:50476616-50476616	stomach	carcinoma; adenocarcinoma	Unknown
c.1059G>A; p.L353L; 7:50470154-50470154	skin	malignant_melanoma	Substitution - coding silent
c.1059G>A; p.L353L; 7:50470154-50470154	skin	malignant_melanoma	Substitution - coding silent
c.1339C>T; p.R447C; 7:50463335-50463335	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1068A>T; p.R356S; 7:50470145-50470145	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1296A>C; p.K432N; 7:50463378-50463378	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1413G>A; p.A471A; 7:50463261-50463261	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1234C>T; p.R412W; 7:50467222-50467222	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1042-3C>T; p.?; 7:50470174-50470174	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.379G>A; p.E127K; 7:50537916-50537916	skin	malignant_melanoma	Substitution - Missense
c.36G>C; p.E12D; 7:50544050-50544050	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.105C>A; p.P35P; 7:50543981-50543981	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1277G>T; p.R426I; 7:50463397-50463397	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1113C>G; p.V371V; 7:50470100-50470100	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.877-2A>T; p.?; 7:50495419-50495419	lung	carcinoma; adenocarcinoma	Unknown
c.1300C>T; p.H434Y; 7:50463374-50463374	skin	malignant_melanoma	Substitution - Missense
c.510G>A; p.A170A; 7:50529268-50529268	ovary	other; neoplasm	Substitution - coding silent
c.1135C>A; p.R379S; 7:50470078-50470078	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.260C>T; p.P87L; 7:50539970-50539970	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.551T>C; p.V184A; 7:50529227-50529227	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1340G>A; p.R447H; 7:50463334-50463334	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.771C>T; p.V257V; 7:50504003-50504003	skin	malignant_melanoma	Substitution - coding silent
c.167T>A; p.I56N; 7:50543919-50543919	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.206C>T; p.T69M; 7:50540024-50540024	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.206C>T; p.T69M; 7:50540024-50540024	breast	carcinoma	Substitution - Missense
c.206C>T; p.T69M; 7:50540024-50540024	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.206C>T; p.T69M; 7:50540024-50540024	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1301A>T; p.H434L; 7:50463373-50463373	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.928G>T; p.D310Y; 7:50495366-50495366	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.315G>T; p.W105C; 7:50539915-50539915	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1134C>G; p.I378M; 7:50470079-50470079	urinary_tract; bladder	carcinoma	Substitution - Missense
c.337G>A; p.E113K; 7:50537958-50537958	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1337T>G; p.L446R; 7:50463337-50463337	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.571G>A; p.A191T; 7:50528280-50528280	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1178G>T; p.R393L; 7:50467278-50467278	liver	carcinoma	Substitution - Missense
c.1178G>T; p.R393L; 7:50467278-50467278	liver	carcinoma	Substitution - Missense
c.85G>T; p.V29F; 7:50544001-50544001	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1238T>C; p.L413P; 7:50467218-50467218	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.469C>T; p.L157L; 7:50529309-50529309	skin	malignant_melanoma	Substitution - coding silent
c.969G>T; p.T323T; 7:50479839-50479839	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.469C>T; p.L157L; 7:50529309-50529309	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.20G>A; p.R7Q; 7:50544066-50544066	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.380A>C; p.E127A; 7:50537915-50537915	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.236A>T; p.Y79F; 7:50539994-50539994	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1350C>T; p.I450I; 7:50463324-50463324	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.123G>A; p.L41L; 7:50543963-50543963	skin	malignant_melanoma	Substitution - coding silent
c.48C>T; p.Y16Y; 7:50544038-50544038	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1117G>T; p.G373*; 7:50470096-50470096	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.330A>T; p.A110A; 7:50537965-50537965	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.881C>T; p.A294V; 7:50495413-50495413	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.26G>C; p.R9T; 7:50544060-50544060	breast	carcinoma	Substitution - Missense
c.398T>C; p.L133S; 7:50537897-50537897	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.552G>A; p.V184V; 7:50529226-50529226	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.174C>T; p.N58N; 7:50543912-50543912	breast	carcinoma	Substitution - coding silent
c.109T>C; p.Y37H; 7:50543977-50543977	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1145T>C; p.V382A; 7:50467311-50467311	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1040G>T; p.R347L; 7:50476625-50476625	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1243-7C>T; p.?; 7:50463438-50463438	soft_tissue; blood_vessel	angiosarcoma	Unknown
c.367G>C; p.G123R; 7:50537928-50537928	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.80G>A; p.R27H; 7:50544006-50544006	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.290_291insG; p.I98fs*38; 7:50539939-50539940	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.138C>A; p.A46A; 7:50543948-50543948	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]