Entrez Gene

Basic Information
Gene ID	1200
Name	TPP1
Synonymous	tripeptidyl peptidase I;TPP1;tripeptidyl peptidase I
Definition	cell growth-inhibiting gene 1 protein\|growth-inhibiting protein 1\|lysosomal pepstatin insensitive protease\|tripeptidyl aminopeptidase\|tripeptidyl-peptidase 1
Position	11p15
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.98delC; p.P33fs*15; 11:6618907-6618907	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.98delC; p.P33fs*15; 11:6618907-6618907	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.37C>A; p.L13I; 11:6619248-6619248	stomach	adenocarcinoma	Substitution - Missense
c.981T>A; p.D327E; 11:6616409-6616409	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.139C>A; p.L47M; 11:6618866-6618866	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.147C>T; p.L49L; 11:6618858-6618858	breast	carcinoma	Substitution - coding silent
c.378C>T; p.I126I; 11:6617628-6617628	skin	malignant_melanoma	Substitution - coding silent
c.982G>T; p.D328Y; 11:6616408-6616408	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.120T>C; p.R40R; 11:6618885-6618885	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.467C>T; p.P156L; 11:6617342-6617342	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1066T>C; p.F356L; 11:6616324-6616324	skin	malignant_melanoma	Substitution - Missense
c.734G>A; p.R245H; 11:6616813-6616813	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.734G>A; p.R245H; 11:6616813-6616813	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.524G>A; p.R175H; 11:6617138-6617138	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.524G>A; p.R175H; 11:6617138-6617138	skin; sole	malignant_melanoma; acral_lentiginous	Substitution - Missense
c.734G>A; p.R245H; 11:6616813-6616813	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.508G>A; p.V170M; 11:6617301-6617301	breast	carcinoma	Substitution - Missense
c.249G>T; p.E83D; 11:6617757-6617757	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1356G>C; p.V452V; 11:6615240-6615240	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.39C>T; p.L13L; 11:6619246-6619246	prostate	adenoma	Substitution - coding silent
c.438G>A; p.T146T; 11:6617371-6617371	liver	carcinoma	Substitution - coding silent
c.1135_1136CC>TT; p.P379F; 11:6616014-6616015	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1334G>A; p.S445N; 11:6615262-6615262	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1334G>A; p.S445N; 11:6615262-6615262	large_intestine; colon	carcinoma	Substitution - Missense
c.1334G>A; p.S445N; 11:6615262-6615262	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.442A>G; p.T148A; 11:6617367-6617367	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1248C>A; p.F416L; 11:6615460-6615460	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.889C>A; p.R297R; 11:6616501-6616501	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.671G>A; p.S224N; 11:6616991-6616991	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1281G>A; p.T427T; 11:6615315-6615315	breast	carcinoma	Substitution - coding silent
c.1281G>A; p.T427T; 11:6615315-6615315	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1138G>A; p.A380T; 11:6616012-6616012	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.617G>A; p.R206H; 11:6617045-6617045	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1340G>A; p.R447H; 11:6615256-6615256	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.53A>C; p.K18T; 11:6619232-6619232	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.605C>T; p.P202L; 11:6617057-6617057	skin	malignant_melanoma	Substitution - Missense
c.1056C>T; p.L352L; 11:6616334-6616334	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1056C>T; p.L352L; 11:6616334-6616334	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.164A>C; p.Q55P; 11:6618841-6618841	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.493C>G; p.P165A; 11:6617316-6617316	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1008C>G; p.Y336*; 11:6616382-6616382	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Nonsense
c.1521C>G; p.L507L; 11:6614896-6614896	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.496_497insC; p.H166fs*22; 11:6617312-6617313	pancreas	carcinoma; ductal_carcinoma	Insertion - Frameshift
c.1338C>T; p.G446G; 11:6615258-6615258	skin	malignant_melanoma	Substitution - coding silent
c.1082G>A; p.S361N; 11:6616068-6616068	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1165G>A; p.G389R; 11:6615543-6615543	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1034T>G; p.M345R; 11:6616356-6616356	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1437A>G; p.P479P; 11:6614980-6614980	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1124G>T; p.R375L; 11:6616026-6616026	liver	carcinoma	Substitution - Missense
c.1124G>T; p.R375L; 11:6616026-6616026	liver	carcinoma	Substitution - Missense
c.807C>T; p.A269A; 11:6616740-6616740	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.293C>T; p.T98M; 11:6617713-6617713	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.969G>T; p.V323V; 11:6616421-6616421	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1003G>A; p.A335T; 11:6616387-6616387	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.456G>A; p.R152R; 11:6617353-6617353	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.781G>A; p.V261I; 11:6616766-6616766	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.316G>A; p.A106T; 11:6617690-6617690	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.733C>T; p.R245C; 11:6616814-6616814	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1050G>T; p.R350R; 11:6616340-6616340	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.27G>C; p.G9G; 11:6619258-6619258	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.1049G>A; p.R350Q; 11:6616341-6616341	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.631T>C; p.L211L; 11:6617031-6617031	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1063C>T; p.L355F; 11:6616327-6616327	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1557C>T; p.T519T; 11:6614681-6614681	skin	malignant_melanoma	Substitution - coding silent
c.752T>G; p.F251C; 11:6616795-6616795	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1280C>T; p.T427M; 11:6615316-6615316	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.688-1G>C; p.?; 11:6616860-6616860	skin	malignant_melanoma	Unknown
c.166C>A; p.Q56K; 11:6618839-6618839	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.987G>A; p.E329E; 11:6616403-6616403	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1663G>T; p.A555S; 11:6614575-6614575	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1300C>A; p.P434T; 11:6615296-6615296	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.802C>T; p.R268W; 11:6616745-6616745	breast	carcinoma	Substitution - Missense
c.654T>C; p.S218S; 11:6617008-6617008	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1157C>A; p.T386N; 11:6615551-6615551	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.665A>T; p.N222I; 11:6616997-6616997	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.510G>A; p.V170V; 11:6617152-6617152	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.622C>T; p.R208*; 11:6617040-6617040	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Nonsense
c.622C>T; p.R208*; 11:6617040-6617040	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.622C>T; p.R208*; 11:6617040-6617040	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1007A>G; p.Y336C; 11:6616383-6616383	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.903G>T; p.Q301H; 11:6616487-6616487	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.540A>G; p.S180S; 11:6617122-6617122	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.278_286delCACTGACCC; p.P93_T95delPLT; 11:6617720-6617728	breast	carcinoma	Deletion - In frame
c.742G>A; p.G248S; 11:6616805-6616805	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1555A>G; p.T519A; 11:6614683-6614683	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.225A>G; p.Q75Q; 11:6618780-6618780	ovary	other; neoplasm	Substitution - coding silent
c.1542A>T; p.G514G; 11:6614875-6614875	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.803G>C; p.R268P; 11:6616744-6616744	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.964A>G; p.T322A; 11:6616426-6616426	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.776G>A; p.R259H; 11:6616771-6616771	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1399C>T; p.P467S; 11:6615197-6615197	skin	malignant_melanoma	Substitution - Missense
c.887-7_887-6delAA; p.?; 11:6616509-6616510	NS	malignant_melanoma	Unknown
c.568G>A; p.V190M; 11:6617094-6617094	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1461G>C; p.L487F; 11:6614956-6614956	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1103_1104delTC; p.S369fs*33; 11:6616046-6616047	lung	carcinoma; large_cell_carcinoma	Deletion - Frameshift
c.1608C>T; p.F536F; 11:6614630-6614630	skin	malignant_melanoma	Substitution - coding silent
c.1260A>C; p.S420S; 11:6615448-6615448	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.165G>A; p.Q55Q; 11:6618840-6618840	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.554G>A; p.R185H; 11:6617108-6617108	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.140T>G; p.L47R; 11:6618865-6618865	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.490G>C; p.A164P; 11:6617319-6617319	skin	malignant_melanoma	Substitution - Missense
c.1122C>T; p.F374F; 11:6616028-6616028	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1122C>T; p.F374F; 11:6616028-6616028	skin	malignant_melanoma	Substitution - coding silent
c.184_185delTC; p.S62fs*25; 11:6618820-6618821	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Deletion - Frameshift
c.1496delC; p.P499fs*20; 11:6614921-6614921	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1496delC; p.P499fs*20; 11:6614921-6614921	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1123C>T; p.R375C; 11:6616027-6616027	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1123C>T; p.R375C; 11:6616027-6616027	NS	malignant_melanoma	Substitution - Missense
c.1123C>T; p.R375C; 11:6616027-6616027	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.813T>G; p.I271M; 11:6616734-6616734	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.933C>T; p.L311L; 11:6616457-6616457	breast	carcinoma	Substitution - coding silent
c.496delC; p.H166fs*17; 11:6617313-6617313	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.119G>C; p.R40P; 11:6618886-6618886	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.913C>T; p.L305L; 11:6616477-6616477	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1238G>A; p.S413N; 11:6615470-6615470	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.312G>T; p.L104F; 11:6617694-6617694	breast	carcinoma	Substitution - Missense
c.1069G>A; p.A357T; 11:6616321-6616321	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.778G>T; p.V260L; 11:6616769-6616769	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1062G>T; p.L354L; 11:6616328-6616328	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.754G>T; p.A252S; 11:6616793-6616793	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.191T>G; p.L64R; 11:6618814-6618814	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.535A>T; p.T179S; 11:6617127-6617127	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]