Entrez Gene

Basic Information
Gene ID	11004
Name	KIF2C
Synonymous	kinesin family member 2C;KIF2C;kinesin family member 2C
Definition	kinesin-like protein 6\|kinesin-like protein KIF2C\|mitotic centromere-associated kinesin
Position	1p34.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1914G>A; p.M638I; 1:44762601-44762601	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2151A>C; p.Q717H; 1:44767152-44767152	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.278G>A; p.R93Q; 1:44747662-44747662	breast	carcinoma	Substitution - Missense
c.1659T>G; p.I553M; 1:44760678-44760678	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.396G>A; p.E132E; 1:44750521-44750521	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.166A>G; p.I56V; 1:44747384-44747384	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.166A>G; p.I56V; 1:44747384-44747384	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.556A>G; p.N186D; 1:44753248-44753248	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1248G>A; p.K416K; 1:44759229-44759229	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.385A>G; p.M129V; 1:44750510-44750510	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.361C>T; p.R121C; 1:44750486-44750486	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2020_2021delTA; p.Y674fs*1; 1:44766874-44766875	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.762C>T; p.I254I; 1:44755931-44755931	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2116C>A; p.L706M; 1:44767117-44767117	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.25G>C; p.A9P; 1:44739957-44739957	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1028C>A; p.T343N; 1:44757606-44757606	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1422C>T; p.F474F; 1:44760334-44760334	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1539C>T; p.G513G; 1:44760451-44760451	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1500G>A; p.A500A; 1:44760412-44760412	thyroid	other; neoplasm	Substitution - coding silent
c.499G>A; p.E167K; 1:44753191-44753191	thyroid	carcinoma	Substitution - Missense
c.970G>A; p.V324I; 1:44756230-44756230	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.551C>A; p.P184H; 1:44753243-44753243	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1150C>A; p.L384M; 1:44758066-44758066	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.792G>A; p.R264R; 1:44755961-44755961	breast	carcinoma	Substitution - coding silent
c.903A>T; p.T301T; 1:44756163-44756163	ovary	other; neoplasm	Substitution - coding silent
c.959C>T; p.S320L; 1:44756219-44756219	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.897C>A; p.D299E; 1:44756157-44756157	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.2007C>T; p.T669T; 1:44766861-44766861	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1436G>A; p.R479Q; 1:44760348-44760348	skin	malignant_melanoma	Substitution - Missense
c.1610C>T; p.T537I; 1:44760629-44760629	pancreas	carcinoma	Substitution - Missense
c.1436G>A; p.R479Q; 1:44760348-44760348	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.603_605delGAA; p.K202delK; 1:44753773-44753775	autonomic_ganglia	neuroblastoma	Deletion - In frame
c.1367+7G>T; p.?; 1:44759355-44759355	liver	carcinoma	Unknown
c.1612C>T; p.P538S; 1:44760631-44760631	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1739G>C; p.R580T; 1:44761971-44761971	breast	carcinoma	Substitution - Missense
c.1498G>A; p.A500T; 1:44760410-44760410	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1498G>A; p.A500T; 1:44760410-44760410	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1498G>A; p.A500T; 1:44760410-44760410	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1498G>A; p.A500T; 1:44760410-44760410	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1498G>A; p.A500T; 1:44760410-44760410	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1415C>T; p.A472V; 1:44760327-44760327	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2054C>G; p.S685C; 1:44766908-44766908	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.301C>T; p.P101S; 1:44747685-44747685	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1951G>A; p.E651K; 1:44762638-44762638	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1149C>T; p.L383L; 1:44758065-44758065	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2093G>C; p.R698P; 1:44766947-44766947	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.2093G>C; p.R698P; 1:44766947-44766947	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2151A>G; p.Q717Q; 1:44767152-44767152	skin	malignant_melanoma	Substitution - coding silent
c.1140C>T; p.D380D; 1:44758056-44758056	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1691C>T; p.T564M; 1:44761923-44761923	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2025C>G; p.D675E; 1:44766879-44766879	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.688T>C; p.W230R; 1:44754774-44754774	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2100C>T; p.V700V; 1:44767101-44767101	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1294G>A; p.V432M; 1:44759275-44759275	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.13T>G; p.S5A; 1:44739945-44739945	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1577G>A; p.C526Y; 1:44760596-44760596	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.531A>T; p.R177R; 1:44753223-44753223	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.619G>A; p.E207K; 1:44753789-44753789	breast	carcinoma	Substitution - Missense
c.637T>G; p.S213A; 1:44753807-44753807	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1037C>T; p.A346V; 1:44757615-44757615	skin	malignant_melanoma	Substitution - Missense
c.1722T>C; p.Y574Y; 1:44761954-44761954	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2106G>A; p.K702K; 1:44767107-44767107	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2103C>G; p.I701M; 1:44767104-44767104	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.137C>A; p.A46E; 1:44740979-44740979	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.529C>T; p.R177*; 1:44753221-44753221	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.595G>A; p.E199K; 1:44753765-44753765	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1747G>A; p.D583N; 1:44761979-44761979	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.167T>C; p.I56T; 1:44747385-44747385	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1051G>T; p.G351*; 1:44757629-44757629	thyroid	other; neoplasm	Substitution - Nonsense
c.419G>A; p.R140H; 1:44750544-44750544	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1841C>T; p.A614V; 1:44762435-44762435	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1841C>T; p.A614V; 1:44762435-44762435	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1841C>T; p.A614V; 1:44762435-44762435	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.834T>C; p.I278I; 1:44756094-44756094	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.486G>C; p.L162F; 1:44753178-44753178	thyroid	carcinoma	Substitution - Missense
c.1837_1838GG>AT; p.G613M; 1:44762431-44762432	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1146C>T; p.F382F; 1:44758062-44758062	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1348G>A; p.D450N; 1:44759329-44759329	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.370G>A; p.A124T; 1:44750495-44750495	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.178G>T; p.D60Y; 1:44747396-44747396	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1038A>G; p.A346A; 1:44757616-44757616	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1214A>G; p.Y405C; 1:44758130-44758130	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1677T>G; p.T559T; 1:44760696-44760696	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1528C>T; p.R510C; 1:44760440-44760440	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1409C>T; p.S470F; 1:44760321-44760321	skin	malignant_melanoma	Substitution - Missense
c.1622A>T; p.E541V; 1:44760641-44760641	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1999G>T; p.E667*; 1:44766853-44766853	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1692G>A; p.T564T; 1:44761924-44761924	skin	malignant_melanoma	Substitution - coding silent
c.797G>A; p.R266H; 1:44755966-44755966	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1435C>T; p.R479*; 1:44760347-44760347	skin; neck	malignant_melanoma	Substitution - Nonsense
c.1435C>T; p.R479*; 1:44760347-44760347	skin	malignant_melanoma	Substitution - Nonsense
c.797G>A; p.R266H; 1:44755966-44755966	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.918C>A; p.N306K; 1:44756178-44756178	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1435C>T; p.R479*; 1:44760347-44760347	pituitary; craniopharyngeal_duct	craniopharyngioma; adamantinomatous	Substitution - Nonsense
c.1762C>A; p.L588M; 1:44762356-44762356	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1506T>C; p.T502T; 1:44760418-44760418	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1A>C; p.M1L; 1:44739933-44739933	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.46G>A; p.A16T; 1:44739978-44739978	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1558C>T; p.L520F; 1:44760470-44760470	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1558C>T; p.L520F; 1:44760470-44760470	urinary_tract; bladder	carcinoma	Substitution - Missense
c.43C>T; p.L15F; 1:44739975-44739975	skin	malignant_melanoma	Substitution - Missense
c.163G>T; p.E55*; 1:44741005-44741005	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2098G>C; p.V700L; 1:44767099-44767099	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.796C>T; p.R266C; 1:44755965-44755965	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1146C>G; p.F382L; 1:44758062-44758062	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1883C>T; p.S628F; 1:44762570-44762570	skin	malignant_melanoma	Substitution - Missense
c.1511G>A; p.S504N; 1:44760423-44760423	skin	malignant_melanoma	Substitution - Missense
c.1511G>A; p.S504N; 1:44760423-44760423	meninges	meningioma; haemangiopericytic	Substitution - Missense
c.2031G>T; p.E677D; 1:44766885-44766885	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.535A>C; p.S179R; 1:44753227-44753227	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1309C>T; p.H437Y; 1:44759290-44759290	ovary	other; neoplasm	Substitution - Missense
c.960G>A; p.S320S; 1:44756220-44756220	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.560C>T; p.S187L; 1:44753252-44753252	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1732A>T; p.T578S; 1:44761964-44761964	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.168T>G; p.I56M; 1:44747386-44747386	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.836A>G; p.D279G; 1:44756096-44756096	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.559T>C; p.S187P; 1:44753251-44753251	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1709G>A; p.S570N; 1:44761941-44761941	ovary	other; neoplasm	Substitution - Missense
c.1137G>T; p.R379R; 1:44758053-44758053	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1294G>T; p.V432L; 1:44759275-44759275	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1836C>T; p.N612N; 1:44762430-44762430	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1345A>C; p.I449L; 1:44759326-44759326	skin	malignant_melanoma	Substitution - Missense
c.840G>C; p.V280V; 1:44756100-44756100	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.840G>C; p.V280V; 1:44756100-44756100	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.175G>A; p.D59N; 1:44747393-44747393	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.683C>T; p.P228L; 1:44754769-44754769	skin; extremity	malignant_melanoma	Substitution - Missense
c.683C>T; p.P228L; 1:44754769-44754769	skin	malignant_melanoma	Substitution - Missense

COSMIC somatic mutation [Top]