Entrez Gene

Basic Information
Gene ID	10403
Name	NDC80
Synonymous	NDC80 kinetochore complex component;NDC80;NDC80 kinetochore complex component
Definition	NDC80 homolog, kinetochore complex component\|NDC80 kinetochore complex component homolog\|highly expressed in cancer protein\|highly expressed in cancer, rich in leucine heptad repeats\|kinetochore associated 2\|kinetochore protein Hec1\|kinetochore protein ND
Position	18p11.32
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1027G>A; p.E343K; 18:2595427-2595427	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1027G>A; p.E343K; 18:2595427-2595427	liver	carcinoma	Substitution - Missense
c.1095C>T; p.D365D; 18:2595495-2595495	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.99A>G; p.Q33Q; 18:2573084-2573084	liver	carcinoma	Substitution - coding silent
c.144G>A; p.P48P; 18:2575031-2575031	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.966C>T; p.A322A; 18:2590113-2590113	NS	NS	Substitution - coding silent
c.99A>G; p.Q33Q; 18:2573084-2573084	liver	carcinoma	Substitution - coding silent
c.1759G>A; p.E587K; 18:2610829-2610829	skin	malignant_melanoma	Substitution - Missense
c.1759G>A; p.E587K; 18:2610829-2610829	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1598A>G; p.E533G; 18:2608740-2608740	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1598A>G; p.E533G; 18:2608740-2608740	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1599G>A; p.E533E; 18:2608741-2608741	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.289C>T; p.R97*; 18:2577855-2577855	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1627G>T; p.E543*; 18:2608769-2608769	lung	carcinoma	Substitution - Nonsense
c.1822G>C; p.D608H; 18:2616467-2616467	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1056A>G; p.L352L; 18:2595456-2595456	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1855C>A; p.L619I; 18:2616500-2616500	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1855C>A; p.L619I; 18:2616500-2616500	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.1220C>T; p.A407V; 18:2595620-2595620	urinary_tract; bladder	carcinoma	Substitution - Missense
c.381G>A; p.K127K; 18:2578046-2578046	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.151G>A; p.E51K; 18:2575038-2575038	breast	carcinoma	Substitution - Missense
c.1813G>C; p.A605P; 18:2616458-2616458	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1885A>G; p.K629E; 18:2616530-2616530	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1093G>T; p.D365Y; 18:2595493-2595493	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.487G>A; p.A163T; 18:2578937-2578937	prostate	carcinoma	Substitution - Missense
c.248C>A; p.P83Q; 18:2577814-2577814	skin	malignant_melanoma	Substitution - Missense
c.884C>T; p.S295L; 18:2590031-2590031	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.884C>T; p.S295L; 18:2590031-2590031	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1873G>C; p.E625Q; 18:2616518-2616518	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.551C>T; p.A184V; 18:2579001-2579001	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.143C>T; p.P48L; 18:2575030-2575030	urinary_tract; bladder	carcinoma	Substitution - Missense
c.143C>T; p.P48L; 18:2575030-2575030	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1757T>C; p.L586S; 18:2610827-2610827	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.533G>T; p.W178L; 18:2578983-2578983	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.257T>G; p.L86R; 18:2577823-2577823	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.339C>T; p.S113S; 18:2578004-2578004	skin	malignant_melanoma	Substitution - coding silent
c.1099G>A; p.E367K; 18:2595499-2595499	breast	carcinoma	Substitution - Missense
c.1099G>A; p.E367K; 18:2595499-2595499	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.349C>G; p.L117V; 18:2578014-2578014	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1099G>C; p.E367Q; 18:2595499-2595499	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1306G>A; p.D436N; 18:2599103-2599103	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.365T>A; p.V122D; 18:2578030-2578030	liver	carcinoma	Substitution - Missense
c.305T>G; p.F102C; 18:2577970-2577970	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1564G>C; p.E522Q; 18:2608706-2608706	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1830A>T; p.E610D; 18:2616475-2616475	skin	malignant_melanoma	Substitution - Missense
c.787T>G; p.F263V; 18:2589227-2589227	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1051C>T; p.R351*; 18:2595451-2595451	skin	malignant_melanoma	Substitution - Nonsense
c.1553T>G; p.I518S; 18:2606503-2606503	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1553T>G; p.I518S; 18:2606503-2606503	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.458G>A; p.R153K; 18:2578123-2578123	urinary_tract; bladder	carcinoma	Substitution - Missense
c.185G>A; p.S62N; 18:2577751-2577751	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1708A>C; p.T570P; 18:2610778-2610778	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1751G>A; p.R584H; 18:2610821-2610821	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.758A>G; p.K253R; 18:2587918-2587918	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.585T>C; p.H195H; 18:2585118-2585118	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1771A>G; p.T591A; 18:2610841-2610841	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1597G>C; p.E533Q; 18:2608739-2608739	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1306G>C; p.D436H; 18:2599103-2599103	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1006G>C; p.A336P; 18:2590153-2590153	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1432delA; p.M480fs*7; 18:2601453-2601453	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1432delA; p.M480fs*7; 18:2601453-2601453	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1432delA; p.M480fs*7; 18:2601453-2601453	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.165G>A; p.S55S; 18:2575052-2575052	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.394C>A; p.L132I; 18:2578059-2578059	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1405G>C; p.E469Q; 18:2601426-2601426	breast	carcinoma	Substitution - Missense
c.582A>T; p.I194I; 18:2585115-2585115	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1016-1G>A; p.?; 18:2595415-2595415	skin	malignant_melanoma	Unknown
c.352C>T; p.Q118*; 18:2578017-2578017	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.859G>A; p.E287K; 18:2589299-2589299	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.199C>T; p.R67W; 18:2577765-2577765	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.249G>T; p.P83P; 18:2577815-2577815	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1857C>T; p.L619L; 18:2616502-2616502	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.415T>C; p.S139P; 18:2578080-2578080	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1789G>A; p.E597K; 18:2610859-2610859	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1726C>T; p.R576*; 18:2610796-2610796	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1010G>T; p.R337I; 18:2590157-2590157	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1727G>A; p.R576Q; 18:2610797-2610797	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1766T>A; p.V589D; 18:2610836-2610836	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1175A>G; p.Q392R; 18:2595575-2595575	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.756delA; p.K253fs*2; 18:2587916-2587916	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1566G>A; p.E522E; 18:2608708-2608708	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1566G>A; p.E522E; 18:2608708-2608708	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.580A>G; p.I194V; 18:2585113-2585113	breast	carcinoma	Substitution - Missense
c.347C>A; p.S116Y; 18:2578012-2578012	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1288G>C; p.E430Q; 18:2599085-2599085	urinary_tract; bladder	carcinoma	Substitution - Missense
c.906C>T; p.S302S; 18:2590053-2590053	skin	malignant_melanoma	Substitution - coding silent
c.1860G>A; p.S620S; 18:2616505-2616505	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1479A>G; p.I493M; 18:2606429-2606429	skin	malignant_melanoma	Substitution - Missense
c.24C>T; p.S8S; 18:2573009-2573009	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.370G>C; p.D124H; 18:2578035-2578035	urinary_tract; bladder	carcinoma	Substitution - Missense
c.640G>T; p.E214*; 18:2585173-2585173	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.707T>G; p.F236C; 18:2587867-2587867	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.730delG; p.D244fs*3; 18:2587890-2587890	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.38G>A; p.R13H; 18:2573023-2573023	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.141A>G; p.K47K; 18:2575028-2575028	stomach	adenocarcinoma	Substitution - coding silent
c.435A>G; p.T145T; 18:2578100-2578100	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.702G>A; p.E234E; 18:2587862-2587862	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1158C>T; p.D386D; 18:2595558-2595558	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1883delA; p.D628fs*9; 18:2616528-2616528	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.1075C>A; p.Q359K; 18:2595475-2595475	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.350T>C; p.L117P; 18:2578015-2578015	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.738G>A; p.M246I; 18:2587898-2587898	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]