| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 846 |
Name | CASR |
Synonym | CAR|EIG8|FHH|FIH|GPRC2A|HHC|HHC1|HYPOC1|NSHPT|PCAR1;calcium-sensing receptor;CASR;calcium-sensing receptor |
Definition | extracellular calcium-sensing receptor|parathyroid Ca(2+)-sensing receptor 1|parathyroid cell calcium-sensing receptor 1 |
Position | 3q13 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | E-cadherin signaling in keratinocytes;PID Curated;200125 |
Pathway | Class C/3 (Metabotropic glutamate/pheromone receptors);PID Reactome;500431 |
Disease | Hypocalcemia, autosomal dominant, with Bartter syndrome;OMIM |
Disease | Hypocalciuric hypercalcemia, type I;OMIM |
Disease | Hyperparathyroidism, neonatal;OMIM |
Disease | primary hyperparathyroidism;GAD |
Disease | total serum calcium;GAD |
Disease | hyperparathyroidism;GAD |
Disease | electrolyte levels;GAD |
Disease | Pancreatitis;FunDO |
Disease | calcium cardiac death heart disease, ischemic myocardial infarct phosphate;GAD |
Disease | Multiple myeloma;FunDO |
Disease | Familial hypocalciuric hypercalcemia;GAD |
Disease | Epilepsy, idiopathic generalized, susceptibility to, 8;OMIM |
Disease | METABOLIC;GAD |
Disease | Hyperparathyroidism;FunDO |
Disease | colorectal cancer;GAD |
Disease | Autoimmune disease;FunDO |
Disease | bone density;GAD |
Disease | Serum calcium;NHGRI |
Disease | Serum phosphorus concentrations;NHGRI |
Disease | CARDIOVASCULAR;GAD |
Disease | Vitamin D deficiency;FunDO |
Disease | Hypocalcemia, autosomal dominant;OMIM |
Disease | CANCER;GAD |
Disease | Kidney failure;FunDO |
Disease | albumin bone density calcium fractures, vertebral hyperparathyroidism kidney stone disease;GAD |
Disease | Colon cancer;FunDO |
Disease | calcium;GAD |
Disease | Primary hyperparathyroidism;FunDO |
Disease | hypercalciuria;GAD |
Disease | hyperparathyroidism, primary;GAD |
Disease | Epilepsy;FunDO |
Disease | Atherosclerosis;FunDO |
External Links | |
Links to Entrez Gene | 846 |
Links to all GeneRIF Items | 846 |
Links to iHOP | 846 |
Sequence Information | |
Nucleotide Sequence | >846 : length: 7026 GCCGCCCAGAGGGTCTGCGGGGGCTGCTGTGGCCGGACCCGAAGGCGGGCGCCGGGAGCG CAGCGAGCCAGACGCGCCTCTCCAAGACCGTGACCTTGGCATAGGGAGCGGGGCTGCGCG CAGTCCTGAGATCAGACCAGAGCTCATCCTCGTGGAGACCCACGGCCGAGGGGCCGGAGC TGCCTCTGTGCGAGGGAGCCCTGGCCGCGGCGCAGGGACTAATGACAAGAAAAGAAGTCT GTACATGTTCAGTACGGATACAGCCATTCATCTTTTCCAAATATTTTCAATCTGAAGTTG ACTGAATCCATGGCTGCAGAACCCACATGTATGGAGGACCAAGTGTACATGTTTATTTTA TTAAATTTCAGAAACAAAAAATAAAACAGGGAAGAAACCAGAATTCCATCAATGAGATCT AATCATCCTTAACATTTCGCTACAGCGGAGCCACAAACTTGGCTTACAGCTTCCTAACAC TCAAAGAAGGAAACAGGAGAAGAGAGAAGATTTGTAATGCCTATAAAATAATTTTGGCCA GGTTTTCCAAAGAAAACCAGAATTTCCATGTGCTTAGAAAGATGTCCCCACGATGTGCTA GAACAGGCTTCTATCGGCGCTTGAGAGCCGATGGTTAAATATTCAGATTTTTTACAAATA TGTTGTTAAACCATTGGTAGCTTGAAACTGACCATGGTGGGAATATTTAGCATACACCAC AAGTCAGGTCTTGTTTTTCTTTTAGAAGCCAGACTACAAGCACACCACCACATGTCCCCA GTGGTCCTCAGACAAAGACACTGTGTGAGGTCAGGAGAGTTGCAAGTGGATGGGGAAAGG CTCAGTGTACAACTTTCTATGTACAATAGAAACCCATCCCTCAGGAGTAGCGGAGAACAG AAACATATGCCTGACCAGAGAATGACTTCAAAGTTACATCAGCAGTCACCCACCCCACCT GAGTCCTTCTTTCCAATAATACCCTTTGGAATTTCATACCTGGGATTACAAAAACTGCTA TGCCCATTGAGGGGCAGACATATCTCCCCATTCAAAGATACACCTAAACAAATGCGAGAA TCTCAGATTACAGACTTTATGCTTTCCACTCAGTCAGCCCTTCCAAGCCCATGTTTCACG GCATCATGAAAAGTGTCCTTCAGGGAAGAAAAAAAGTGTCCCATACCAAAATAAGCAATA ATCTTTATTGCAGGACTTCTCAGAGCCTTTAAGGAGGCATATGTGCTCCTGTGGCAGAGT GTACATTAGTTCCCAAACTTGTTTTACCCCAGAACACTTCCTGGTGACACATCTTGGGAC ATCATACTGAAAAATGCCACCCTGGGTAGTCAGGGTTCCTTATGATTTGGAGAGGCAACG CCAGGATGTTATTCCACAGAAATGTTTCTTTTATGTAGGACTTGAGGCTCTGGCATTTTT CTTTATAAAAACATGAGTTGCATATCTTCGCTTTTCAAATGAACCATTTCATTAACTCTG TTGGTGTTCATACATCCGTCAGCAGAGCTGACTTAAGGCATAAAGGAAACAGTTCAGGAC AAGAAGTTTCTTAACTTCCTGTGGGCTATGTCGCCAGCAACTCACTCAGTCCTATGTGGA CACAGAGTTTGTTATGTTGCCGGCAGTACACACAAGTATGCACCCACTCAACCATCATCA TGGAGCCCCTCCATGTTCCAGGCCGCGGATGGGACAGACCTGGCCCTGTCTTCAAGGAGC TCAGGATGCAGCATTAATGAATGTCAGCTTCCTCTATTTACAGCCTTTCTTTGCTTTGTC TAGGCTTCTGTTTCCCCACTTTGCTCTGTGCCCTGTGCTGCTCCTCACCACTCTTGTTCA TCCTTTTCCCTCCCTTCCCTGATAGCTTTTTCCAATGACTCACAAGAACCCACCCAGCTC AGCTGCTTTTCATTACGCTCCTGTCTTTGCATTTTTCCAACTCAATTAAGCCATTACCAG AACTAAATGAGGCATGGACTCCCCAAAAGTCACACCTGTTGTCAGGGAGATGGAGGGCAA GACCATGTGCAGCTGGCAGGCAGACAGCAGAAGCCGGGCTTGGGCTTGCGGGAGGCAGCC AAGGGTGACCGGGCAATTTGTGTTTCCCCCAGTGCCGAAAGAGGGCCCTCATTTTAAAAC AACATGTGCCTTGCTTTGGTACAGAAGGAATGAAGTCTGATATAGAACTAGGGATGGCCG TATTGGTGATGGCAGAAGGCATCACAGGAGGCCTCTGCATGATGTGGCTTCCAAAGACTC AAGGACCACCCACATTACAAGTCTGGATTGAGGAAGGCAGAAATGGAGATTCAAACACCA CGTCTTCTATTATTTTATTAATCAATCTGTAGACATGTGTCCCCACTGCAGGGAGTGAAC TGCTCCAAGGGAGAAACTTCTGGGAGCCTCCAAACTCCTAGCTGTCTCATCCCTTGCCCT GGAGAGACGGCAGAACCATGGCATTTTATAGCTGCTGCTGGGTCCTCTTGGCACTCACCT GGCACACCTCTGCCTACGGGCCAGACCAGCGAGCCCAAAAGAAGGGGGACATTATCCTTG GGGGGCTCTTTCCTATTCATTTTGGAGTAGCAGCTAAAGATCAAGATCTCAAATCAAGGC CGGAGTCTGTGGAATGTATCAGGTATAATTTCCGTGGGTTTCGCTGGTTACAGGCTATGA TATTTGCCATAGAGGAGATAAACAGCAGCCCAGCCCTTCTTCCCAACTTGACGCTGGGAT ACAGGATATTTGACACTTGCAACACCGTTTCTAAGGCCTTGGAAGCCACCCTGAGTTTTG TTGCTCAAAACAAAATTGATTCTTTGAACCTTGATGAGTTCTGCAACTGCTCAGAGCACA TTCCCTCTACGATTGCTGTGGTGGGAGCAACTGGCTCAGGCGTCTCCACGGCAGTGGCAA ATCTGCTGGGGCTCTTCTACATTCCCCAGGTCAGTTATGCCTCCTCCAGCAGACTCCTCA GCAACAAGAATCAATTCAAGTCTTTCCTCCGAACCATCCCCAATGATGAGCACCAGGCCA CTGCCATGGCAGACATCATCGAGTATTTCCGCTGGAACTGGGTGGGCACAATTGCAGCTG ATGACGACTATGGGCGGCCGGGGATTGAGAAATTCCGAGAGGAAGCTGAGGAAAGGGATA TCTGCATCGACTTCAGTGAACTCATCTCCCAGTACTCTGATGAGGAAGAGATCCAGCATG TGGTAGAGGTGATTCAAAATTCCACGGCCAAAGTCATCGTGGTTTTCTCCAGTGGCCCAG ATCTTGAGCCCCTCATCAAGGAGATTGTCCGGCGCAATATCACGGGCAAGATCTGGCTGG CCAGCGAGGCCTGGGCCAGCTCCTCCCTGATCGCCATGCCTCAGTACTTCCACGTGGTTG GCGGCACCATTGGATTCGCTCTGAAGGCTGGGCAGATCCCAGGCTTCCGGGAATTCCTGA AGAAGGTCCATCCCAGGAAGTCTGTCCACAATGGTTTTGCCAAGGAGTTTTGGGAAGAAA CATTTAACTGCCACCTCCAAGAAGGTGCAAAAGGACCTTTACCTGTGGACACCTTTCTGA GAGGTCACGAAGAAAGTGGCGACAGGTTTAGCAACAGCTCGACAGCCTTCCGACCCCTCT GTACAGGGGATGAGAACATCAGCAGTGTCGAGACCCCTTACATAGATTACACGCATTTAC GGATATCCTACAATGTGTACTTAGCAGTCTACTCCATTGCCCACGCCTTGCAAGATATAT ATACCTGCTTACCTGGGAGAGGGCTCTTCACCAATGGCTCCTGTGCAGACATCAAGAAAG TTGAGGCGTGGCAGGTCCTGAAGCACCTACGGCATCTAAACTTTACAAACAATATGGGGG AGCAGGTGACCTTTGATGAGTGTGGTGACCTGGTGGGGAACTATTCCATCATCAACTGGC ACCTCTCCCCAGAGGATGGCTCCATCGTGTTTAAGGAAGTCGGGTATTACAACGTCTATG CCAAGAAGGGAGAAAGACTCTTCATCAACGAGGAGAAAATCCTGTGGAGTGGGTTCTCCA GGGAGGTGCCCTTCTCCAACTGCAGCCGAGACTGCCTGGCAGGGACCAGGAAAGGGATCA TTGAGGGGGAGCCCACCTGCTGCTTTGAGTGTGTGGAGTGTCCTGATGGGGAGTATAGTG ATGAGACAGATGCCAGTGCCTGTAACAAGTGCCCAGATGACTTCTGGTCCAATGAGAACC ACACCTCCTGCATTGCCAAGGAGATCGAGTTTCTGTCGTGGACGGAGCCCTTTGGGATCG CACTCACCCTCTTTGCCGTGCTGGGCATTTTCCTGACAGCCTTTGTGCTGGGTGTGTTTA TCAAGTTCCGCAACACACCCATTGTCAAGGCCACCAACCGAGAGCTCTCCTACCTCCTCC TCTTCTCCCTGCTCTGCTGCTTCTCCAGCTCCCTGTTCTTCATCGGGGAGCCCCAGGACT GGACGTGCCGCCTGCGCCAGCCGGCCTTTGGCATCAGCTTCGTGCTCTGCATCTCATGCA TCCTGGTGAAAACCAACCGTGTCCTCCTGGTGTTTGAGGCCAAGATCCCCACCAGCTTCC ACCGCAAGTGGTGGGGGCTCAACCTGCAGTTCCTGCTGGTTTTCCTCTGCACCTTCATGC AGATTGTCATCTGTGTGATCTGGCTCTACACCGCGCCCCCGTCAAGCTACCGCAACCAGG AGCTGGAGGATGAGATCATCTTCATCACGTGCCACGAGGGCTCCCTCATGGCCCTGGGCT TCCTGATCGGCTACACCTGCCTGCTGGCTGCCATCTGCTTCTTCTTTGCCTTCAAGTCCC GGAAGCTGCCGGAGAACTTCAATGAAGCCAAGTTCATCACCTTCAGCATGCTCATCTTCT TCATCGTCTGGATCTCCTTCATTCCAGCCTATGCCAGCACCTATGGCAAGTTTGTCTCTG CCGTAGAGGTGATTGCCATCCTGGCAGCCAGCTTTGGCTTGCTGGCGTGCATCTTCTTCA ACAAGATCTACATCATTCTCTTCAAGCCATCCCGCAACACCATCGAGGAGGTGCGTTGCA GCACCGCAGCTCACGCTTTCAAGGTGGCTGCCCGGGCCACGCTGCGCCGCAGCAACGTCT CCCGCAAGCGGTCCAGCAGCCTTGGAGGCTCCACGGGATCCACCCCCTCCTCCTCCATCA GCAGCAAGAGCAACAGCGAAGACCCATTCCCACAGCCCGAGAGGCAGAAGCAGCAGCAGC CGCTGGCCCTAACCCAGCAAGAGCAGCAGCAGCAGCCCCTGACCCTCCCACAGCAGCAAC GATCTCAGCAGCAGCCCAGATGCAAGCAGAAGGTCATCTTTGGCAGCGGCACGGTCACCT TCTCACTGAGCTTTGATGAGCCTCAGAAGAACGCCATGGCCCACAGGAATTCTACGCACC AGAACTCCCTGGAGGCCCAGAAAAGCAGCGATACGCTGACCCGACACGAGCCATTACTCC CGCTGCAGTGCGGGGAAACGGACTTAGATCTGACCGTCCAGGAAACAGGTCTGCAAGGAC CTGTGGGTGGAGACCAGCGGCCAGAGGTGGAGGACCCTGAAGAGTTGTCCCCAGCACTTG TAGTGTCCAGTTCACAGAGCTTTGTCATCAGTGGTGGAGGCAGCACTGTTACAGAAAACG TAGTGAATTCATAAAATGGAAGGAGAAGACTGGGCTAGGGAGAATGCAGAGAGGTTTCTT GGGGTCCCAGGGAAGAGGAATCGCCCCAGACTCCTTTCCTCTGAGGAAGAAGGGATAATA GACACATCAAATGCCCCGAATTTAGTCACACCATCTTAAATGACAGTGAATTGACCCATG TTCCCTTTAAAATTAAAAAAAAGAAGAGCCTTGTGTTTCTGTGGTTGCATTTGTCAAAGC ATTGAGATCTCCACGGTCAGATTTGCTGTTCACCCACATCTAATGTCTCTTCCTCTGTTC TATCCCACCCAACAGCTCAGAGATGAAACTATGGCTTTAAACTACCCTCCAGAGTGTGCA GACTGATGGGACATCAAATTTGCCACCACTAGAGCTGAGAGTCTGAAAGACAGAATGTCA CCAGTCCTGCCCAATGCCTTGACAACAGACTGAATTTTAAATGTTCACAACATAAGGAGA ATGTATCTCCTCCTATTTATGAAAACCATATGATATTTTGTCTCCTACCTGCTGCTGCTA TTATGTAACATCCAGAAGGTTTGCACCCCTCCTATACCATATGTCTGCTTCTGTCCAGGA CATGATACTGATGCCATGTTTAGATTCCAGGATCACAAGAATCACCTCAAATTGTTAGGA AGGGACTGCATAAACCAATGAGCTGTATCTGTAATTAATATTCCTATATGTAGCTTTATC CTTAGGAAAATGCTTCTGTTGTAATAGTCCATGGACAATATAAACTGAAAAATGTCAGTC TGGTTTATATAAGGCAGTATTATTGAGCTCTATTTCCCCACCCCACTATCCTCACTCCCA TAAGCTAAGCCTTATGTGAGCCCCTTCAGGGACTCAAGGGTCCAGAAGTCCCTCCCATCT CTACCCCAAAGAATTCCTGAAGCCAGATCCACCCTATCCCTGTACAGAGTAAGTTCTCAA TTATTGGCCTGCTAATAGCTGCTAGGGTAGGAAAGCGTGGTTCCAAGAAAGATCCACCCT CAAATGTCAGAGCTATGTTCCCTCCAGCAGTGGTATTAATACTGCCGGTCACCCAGGCTC TGGAGCCAGAGAGACAGACCGGGGTTCAAGCCATGGCTTCGTCATTTGCAAGCTGAGTGA CTGTAGGCAGGGAACCTTAACCTCTCTAAGCCACAGCTTCTTCATCTTTAAAATAAGGAT AATAATCATTCTTTCCCCTCAGAGCTCTTATGTGGATTAAACGAGATAATGTATATAAAG TACTTTAGCCTGGTACCTAGCACACAATAAGCATTCAATAAATATTAGTTAATATTATTA CTGATA |
Protein Sequence | >846 : length: 1088 MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC IRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS ELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWA SSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHL QEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNV YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREPLTF VLSVLQVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFW SNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNREL SYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKI PTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSL MALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYG KFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLR RSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTL PQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRH QPLLPLQCGETDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGST VTENVVNS |