| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5327 |
Name | PLAT |
Synonym | T-PA|TPA;plasminogen activator, tissue;PLAT;plasminogen activator, tissue |
Definition | alteplase|plasminogen activator, tissue type|reteplase|t-plasminogen activator|tissue plasminogen activator (t-PA)|tissue-type plasminogen activator |
Position | 8p12 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Signaling by PDGF;Reactome;REACT:16888 |
Pathway | Signaling by PDGF;PID Reactome;500508 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Dissolution of Fibrin Clot;PID Reactome;500304 |
Pathway | keratinocyte differentiation;PID BioCarta;100119 |
Pathway | Complement and coagulation cascades;KEGG PATHWAY;hsa04610 |
Pathway | fibrinolysis pathway;PID BioCarta;100164 |
Pathway | Blood coagulation;PANTHER;P00011 |
Pathway | platelet amyloid precursor protein pathway;PID BioCarta;100072 |
Pathway | Plasminogen activating cascade;PANTHER;P00050 |
Pathway | amb2 Integrin signaling;PID Curated;200108 |
Disease | Ischemia;FunDO |
Disease | tissue-type plasminogen activator levels;GAD |
Disease | Lung cancer;FunDO |
Disease | Periodontitis;FunDO |
Disease | vascular t-PA release;GAD |
Disease | Rheumatoid arthritis;FunDO |
Disease | Leukemia;FunDO |
Disease | Polycystic ovary syndrome;FunDO |
Disease | Liver disease;FunDO |
Disease | Systemic infection;FunDO |
Disease | gastric ulcer;GAD |
Disease | Pancreas cancer;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | Hyperfibrinolysis, familial, due to increased release of PLAT;OMIM |
Disease | CARDIOVASCULAR;GAD |
Disease | Stroke;GAD |
Disease | Late pregnancy;FunDO |
Disease | Stroke;FunDO |
Disease | Myocardial Infarction;GAD |
Disease | Hemorrhagic disorder;FunDO |
Disease | Multiple sclerosis;FunDO |
Disease | Hypertension;FunDO |
Disease | Ovarian cancer;FunDO |
Disease | Thrombophilia, familial, due to decreased release of PLAT;OMIM |
Disease | Antiphospholipid syndrome;FunDO |
Disease | Atherosclerosis;FunDO |
External Links | |
Links to Entrez Gene | 5327 |
Links to all GeneRIF Items | 5327 |
Links to iHOP | 5327 |
Sequence Information | |
Nucleotide Sequence | >5327 : length: 3173 ATGGCCCTGTCCACTGAGCATCCTCCCGCCACACAGAAACCCGCCCAGCCGGGGCCACCG ACCCCACCCCCTGCCTGGAAACTTAAAGGAGGCCGGAGCTGTGGGGAGCTCAGAGCTGAG ATCCTACAGGAGTCCAGGGCTGGAGAGAAAACCTCTGCGAGGAAAGGGAAGGAGCAAGCC GTGAATTTAAGGGACGCTGTGAAGCAATCATGGATGCAATGAAGAGAGGGCTCTGCTGTG TGCTGCTGCTGTGTGGAGCAGTCTTCGTTTCGCCCAGCCAGGAAATCCATGCCCGATTCA GAAGAGGAGCCAGATCTTACCAAGTGATCTGCAGAGATGAAAAAACGCAGATGATATACC AGCAACATCAGTCATGGCTGCGCCCTGTGCTCAGAAGCAACCGGGTGGAATATTGCTGGT GCAACAGTGGCAGGGCACAGTGCCACTCAGTGCCTGTCAAAAGTTGCAGCGAGCCAAGGT GTTTCAACGGGGGCACCTGCCAGCAGGCCCTGTACTTCTCAGATTTCGTGTGCCAGTGCC CCGAAGGATTTGCTGGGAAGTGCTGTGAAATAGATACCAGGGCCACGTGCTACGAGGACC AGGGCATCAGCTACAGGGGCACGTGGAGCACAGCGGAGAGTGGCGCCGAGTGCACCAACT GGAACAGCAGCGCGTTGGCCCAGAAGCCCTACAGCGGGCGGAGGCCAGACGCCATCAGGC TGGGCCTGGGGAACCACAACTACTGCAGAAACCCAGATCGAGACTCAAAGCCCTGGTGCT ACGTCTTTAAGGCGGGGAAGTACAGCTCAGAGTTCTGCAGCACCCCTGCCTGCTCTGAGG GAAACAGTGACTGCTACTTTGGGAATGGGTCAGCCTACCGTGGCACGCACAGCCTCACCG AGTCGGGTGCCTCCTGCCTCCCGTGGAATTCCATGATCCTGATAGGCAAGGTTTACACAG CACAGAACCCCAGTGCCCAGGCACTGGGCCTGGGCAAACATAATTACTGCCGGAATCCTG ATGGGGATGCCAAGCCCTGGTGCCACGTGCTGAAGAACCGCAGGCTGACGTGGGAGTACT GTGATGTGCCCTCCTGCTCCACCTGCGGCCTGAGACAGTACAGCCAGCCTCAGTTTCGCA TCAAAGGAGGGCTCTTCGCCGACATCGCCTCCCACCCCTGGCAGGCTGCCATCTTTGCCA AGCACAGGAGGTCGCCCGGAGAGCGGTTCCTGTGCGGGGGCATACTCATCAGCTCCTGCT GGATTCTCTCTGCCGCCCACTGCTTCCAGGAGAGGTTTCCGCCCCACCACCTGACGGTGA TCTTGGGCAGAACATACCGGGTGGTCCCTGGCGAGGAGGAGCAGAAATTTGAAGTCGAAA AATACATTGTCCATAAGGAATTCGATGATGACACTTACGACAATGACATTGCGCTGCTGC AGCTGAAATCGGATTCGTCCCGCTGTGCCCAGGAGAGCAGCGTGGTCCGCACTGTGTGCC TTCCCCCGGCGGACCTGCAGCTGCCGGACTGGACGGAGTGTGAGCTCTCCGGCTACGGCA AGCATGAGGCCTTGTCTCCTTTCTATTCGGAGCGGCTGAAGGAGGCTCATGTCAGACTGT ACCCATCCAGCCGCTGCACATCACAACATTTACTTAACAGAACAGTCACCGACAACATGC TGTGTGCTGGAGACACTCGGAGCGGCGGGCCCCAGGCAAACTTGCACGACGCCTGCCAGG GCGATTCGGGAGGCCCCCTGGTGTGTCTGAACGATGGCCGCATGACTTTGGTGGGCATCA TCAGCTGGGGCCTGGGCTGTGGACAGAAGGATGTCCCGGGTGTGTACACCAAGGTTACCA ACTACCTAGACTGGATTCGTGACAACATGCGACCGTGACCAGGAACACCCGACTCCTCAA AAGCAAATGAGATCCCGCCTCTTCTTCTTCAGAAGACACTGCAAAGGCGCAGTGCTTCTC TACAGACTTCTCCAGACCCACCACACCGCAGAAGCGGGACGAGACCCTACAGGAGAGGGA AGAGTGCATTTTCCCAGATACTTCCCATTTTGGAAGTTTTCAGGACTTGGTCTGATTTCA GGATACTCTGTCAGATGGGAAGACATGAATGCACACTAGCCTCTCCAGGAATGCCTCCTC CCTGGGCAGAAAGTGGCCATGCCACCCTGTTTTCAGCTAAAGCCCAACCTCCTGACCTGT CACCGTGAGCAGCTTTGGAAACAGGACCACAAAAATGAAAGCATGTCTCAATAGTAAAAG ATAACAAGATCTTTCAGGAAAGACGGATTGCATTAGAAATAGACAGTATATTTATAGTCA CAAGAGCCCAGCAGGGCCTCAAAGTTGGGGCAGGCTGGCTGGCCCGTCATGTTCCTCAAA AGCACCCTTGACGTCAAGTCTCCTTCCCCTTTCCCCACTCCCTGGCTCTCAGAAGGTATT CCTTTTGTGTACAGTGTGTAAAGTGTAAATCCTTTTTCTTTATAAACTTTAGAGTAGCAT GAGAGAATTGTATCATTTGAACAACTAGGCTTCAGCATATTTATAGCAATCCATGTTAGT TTTTACTTTCTGTTGCCACAACCCTGTTTTATACTGTACTTAATAAATTCAGATATATTT TTCACAGTTTTTCCAAAATCAGAGTGGAATGGTTTTGTTATAGATGCTGTATCCCACTCT TTATTCATGTTCACATTTTAAAATCATTTGGAATTCTGCTTCACTCGCTTAACATATACA CAACACCTGTAACATACAAGGCAATGGGCTAGGTGCTCCAGACCGGGAAAAGGAGGGACA GGAATGCTTGGTCTGATGGGCTAATATGGCATTTAGAGAAGTACCAAGGTACAGTGGAGC CGGTCACAAAAGGGCAGACTTGTAGTAGAATTCAGTTGCAAGAGGGATTGGGGAATCTTA AGGAAAAAATAGAATCTTAAGGAAAAAATAACTGGGTGAGACGTGGACTGTGGACAGGTG TGGAAAAGGCACTCTCCATGGAGGTATGAATATGTAGAGGGCCAAGAGAGGGGAGTACAG GGAGAAATGAGTTGAGCTTGTCTGAAGTGAACTTCAGGAAGAGGAACATAGGCTGGAATT TAGATTATGGGGGCTCTGAACACCAAACTGAGTTTGGACTTAATTGACTTCTG |
Protein Sequence | >5327 : length: 562 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK DVPGVYTKVTNYLDWIRDNMRP |